Many attempts have been made to elucidate the pathogenesis of urolithiasis from the aspect of crystal formation, and most of the studies have used artificial urine. However, crystal formation in artificial urine differs from that in human urine which contains a variety of crystallization inhibitors. We investigated the mechanism of calcium-oxalate (CaOx) crystal formation and the effects of crystal-related substances in human urine on CaOx crystallization. This was done by determining their urinary levels in order to show differences in crystallization occurrence between stone formers (SF) and normal subjects (NS).
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