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Urolithiasis pp 425-428 | Cite as

The Effect of Vitamin D on Conversion of Ethylene Glycol to Glycolate and Oxalate

  • A. Halabe
  • N. L. M. Wong
  • L. Hagen
  • H. Hughes
  • R. A. L. Sutton

Abstract

Vitamin D3 through its active metabolite, 1, 25(OH)2D3, plays a major role in calcium and phosphorus homeostasis, One-alpha-hydroxy vitamin D (la) is a synthetic analog with very high biological potency which is useful clinically. After administration, the compound is hydroxylated by the liver at the “25 position” on the molecule and converted to 1, 25(OH)2D3. Increased urinary calcium and oxalate excretion are important risk factors for kidney stone formation (1). One-alpha vitamin D3 has been used along with ethylene-glycol (EG) feeding to induce hypercalciuria and hyper-oxaluria, and hence calcium-oxalate kidney stones in experimental rats (2).

Keywords

Kidney Stone Glycolic Acid Urinary Oxalate Glyoxylic Acid Oxalate Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    BEC Nordin, in: “Advances in Internal Medicine”, W Dock and W Snapper, eds., Yearbook Medical Publishers, Chicago (1967).Google Scholar
  2. 2.
    Y Okada, J Kawamujra, YJ Kuo, and O Yoshida, in: “Urinary Stone”, RL Ryall, JG Brockis, and B Finlayson, eds, Churchill Livingstone, Edinburgh (1984).Google Scholar
  3. 3.
    H Hughes, L Hagen, and RAL Sutton, Anal. Biochem. 119: 1 (1982).PubMedCrossRefGoogle Scholar
  4. 4.
    RP Singh and GH Nancollas, Kidney Int. 28: 985 (1985).PubMedCrossRefGoogle Scholar
  5. 5.
    H Hughes, L Hagen, and RAL Sutton, Clin. Chem. 32: 1002 (1986).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • A. Halabe
    • 1
  • N. L. M. Wong
    • 1
  • L. Hagen
    • 1
  • H. Hughes
    • 1
  • R. A. L. Sutton
    • 1
  1. 1.Vancouver General HospitalThe University of British ColumbiaVancouverCanada

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