Abstract
In vitro proliferation, differentiation, and functional activation of hematopoietic progenitor cells are regulated by colony-stimulating factors (CSF’s). The four major recombinant human CSF’s—interleukin-3 (IL-3), granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), and megakaryocyte CSF—have been characterized as mainly responsible for the process whereby bone marrow progenitors mature into granulocytes and macrophages.1 Recent progress in molecular cloning of human and murine genes for these hematopoietic growth and differentiation factors has provided large amounts of highly purified recombinant glycoproteins.2–5 All four factors are also being investigated for their clinical efficacy in alleviating various insufficiencies of the blood-cell-forming system.6–8
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References
Clark, S. C., and Kamen, R. The human hematopoietic colony-stimulating factors. Science 236: 1229–1237, 1987.
Yang, Y. C., Ciarletta, A. B., Temple, P. A., et al. Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3. Cell 47: 3–10, 1986.
Wong, G. G., Temple, P. A., Leary, A. C., et al. Human CSF-1: Molecular cloning and expression of 4-kb cDNA encoding the human urinary protein. Science 235: 1504–1509, 1987.
Cantrell, M. A., Anderson, D., Cerretti, D. P., et al. Cloning, sequence and expression of a human granulocyte-macrophage colony-stimulating factor. Proc Nat! Acad Sci USA 82: 6250–6254, 1985.
Nagata, S., Tsuchiya, M., Asano, S., et al. The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor. EMBO J 5: 575–581, 1986.
Antin, J. H., Smith, B. R., Holmes, W., et al. Phase I/II study of recombinant human granulocyte-macrophage colony-stimulating factors in aplastic anemia and myelodysplastic syndrome. Blood 72: 705–713, 1988.
Antman, K. S., Griffin, J. D., Elias, A., et al. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N Engl J Med 319: 593–598, 1988.
Nemunaitis, J., Singer, J. W., Buckner, C. D., et al. Use of recombinant human granulocyte-macrophage colony-stimulating factor in autologous marrow transplantation for lymphoid malignancies. Blood 72: 834–836, 1988.
Paquette, R. L., Zhou, J. Y., Yang, Y. C., et al. Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro. Blood 71: 1596–1600, 1988.
Ikebuchi, K., Clark, S. C., Ihle, J. N., et al. Granulocyte colony-stimulating factor enhances interleukin-3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci USA 85: 3445–3449, 1988.
Krumwieh, D., Weinmann, E., and Siebold, B., et al. Preclinical studies on synergistic effects of IL-1, IL-3, G-CSF, and GM-CSF in cynomolgus monkeys. In: Proceedings of the International Conference on Blood Cell Growth Factors: Their Biology and Clinical Application. 8–12 October 1989, Capri, Italy, in press.
Donahue, R. E., Seehra, J., Metzger, M., et al. Human IL-3 and GM-CSF act synergistically in stimulating hematopoiesis in primates. Science 241: 1820–1823, 1988.
Valent, P., Geissler, K., Mayer, P., et al. The in vivo effects of IL-3 and GM-CSF in primates. Molecular Biotherapy 1(Suppl): 67 (Abstract), 1989.
Nicola, N. Why do hematopoietic growth factor receptors interact with each other? Immunol Today 8: 134–139, 1987.
Lopez, A. F., Dyson, P. G., To, B. L., et al. Recombinant human interleukin-3 stimulation of hematopoiesis in humans: Loss of responsiveness with differentiation in the neutrophilic myeloid series. Blood 72: 1797–1804, 1988.
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Krumwieh, D., Weinmann, E., Siebold, B., Seiler, F.R. (1990). Effects of Combined Application of IL-3 and G-CSF on Subhuman Primates. In: Browne, D., Weiss, J.F., MacVittie, T.J., Pillai, M.V. (eds) Treatment of Radiation Injuries. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0864-3_7
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DOI: https://doi.org/10.1007/978-1-4899-0864-3_7
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