Significance of the Extracellular Matrix for the Regeneration of Sensory Corpuscles, with Special Reference to Pacinian Corpuscles

  • Chizuka Ide

Abstract

The Pacinian corpuscle consists of an axon terminal and specialized non-neuronal cells of an inner and an outer core (Pease and Quilliam, 1957; Nishi et al., 1969; Munger, 1971; Halata, 1977; Chouchkov, 1978; Malinovsky and Pac, 1982). The inner core is formed by densely packed thin cytoplasmic processes (lamellae) of lamellar cells which surround the axon terminal in a bilaterally symmetrical fashion. These inner core lamellar cells are thought to be derived from Schwann cells. There are thin spaces between neighboring lamellae, in which an extracellular matrix including basal lamina-like material and fine collagen fibrils is present. The outer core is composed of loosely piled layers of thin cells concentrically encircling the inner core. There are definite basal laminae on these outer core cells and thin processes. The outer core cells are extensions of the perineural epithelial cells of the innervating nerve (Shanta and Bourne, 1968). The axon terminal is characterized by an accumulation of mitochondria beneath the axolemma and by small cytoplasmic processes (axonal spines) emanating from the axolemma (Munger et al., 1987; Ide et al., 1987a). It has been demonstrated that basal laminae can serve as conduits for regenerating axons in the peripheral nerve (Ide et al., 1983; Osawa et al., 1986). As described above there are extracelluar matrices containing basal lamina-like material in the inner core of Pacinian corpuscles.

Keywords

Migration Fibril Paraformaldehyde Glutaraldehyde Laminin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Chouchkov, Ch., 1978, Cutaneous Receptors, in: A. Brodai, W. Hild, J. van Limborgh, R. Ortmann, T.H. Schiebler, G. Tondury, and E. Wolf (Eds), Adv. Anat. Embryol. Cell Biol. 54, Springer, Berlin, pp. 41–53.Google Scholar
  2. Halata, Z., 1977, The ultrastructure of the sensory nerve endings in the articular capsule of the knee joint of the domestic cat (Ruffini corpuscles and Pacinian corpuscles), J. Anat., 124: 717–729.PubMedGoogle Scholar
  3. Ide, C., 1983, Nerve regeneration and Schwann cell basal lamina: observations of the long-term regeneration, Arch. Histol. Jap., 46, 243–257.PubMedCrossRefGoogle Scholar
  4. Ide, C., 1986, Basal laminae and Meissner corpuscle regeneration, Brain Res., 384, 311–322.PubMedCrossRefGoogle Scholar
  5. Ide, C., 1987, Role of extracellular matrix on the regeneration of a Pacinian corpuscle, Brain Res., 413; 155–169.PubMedCrossRefGoogle Scholar
  6. Ide, C., and Saito, T., 1980, Electron microscopic histochemistry of cholinesterase activity of Vater-Pacini corpuscles, Acta Histochem. Cytochem., 13, 298–305.CrossRefGoogle Scholar
  7. Ide, C., Tohyama, K., Yokota, R., Nitatori, T., and Onodera, S., 1983, Schwann cell basal lamina and nerve regeneration, Brain Res., 288, 61–75.PubMedCrossRefGoogle Scholar
  8. Ide, C., Yoshida, Y., Hayashi, S., Takashio, M., and Munger, B.L., 1987a, A re-evaluation of the cytology of cat Pacinian corpuscles. II. The extreme tip. Cell Tiss. Res., (in press).Google Scholar
  9. Ide, C., Nitatori, T., and Munger, B.L., 1987b, The cytology of human Pacinian corpuscles: evidence for sprouting of the central axon. Arch. Histol. Jap., (in press).Google Scholar
  10. Malinovsky, L., and Pac, L., 1982, “Morphology of Sensory Corpuscle in Mammals.” J.E. Purkyne University Brno, Medical Faculty Brno.Google Scholar
  11. Munger, B.L., 1971, Pattern of organization of peripheral sensory receptors, in: “Handbook of Sensory Physiology,” W.R. Loewenstein (ed), Vol. 1 Springer, New York, pp. 523–556.Google Scholar
  12. Munger, B.L. Yoshida, Y., Hayashi, S., Osawa, T., and Ide, C., 1987, A re-evaluation of the cytology of Pacinian corpuscles. I. The inner core and clefts, Cell Tiss. Res., (in press).Google Scholar
  13. Nishi, K., Oura, C., and Pallie, W., 1969, Fine structure of Pacinian corpuscles in the mesentery of the cat. J. Cell Biol., 43: 539–553.PubMedCrossRefGoogle Scholar
  14. Osawa, T., Ide, C., and Tohyama, K., 1986, Nerve regeneration through the allogenic nerve grafts in mice, Arch. Histol. Jap., 49, 68–81.CrossRefGoogle Scholar
  15. Pease, D.C., and Quilliam, T.A., 1957, Electron microscopy of the Pacinian corpuscle. J. Biophy. Biochem. Cytol., 3: 331–347.CrossRefGoogle Scholar
  16. Sanes, J.R., Marshall, L.M., and McMahan, U.I., 1978, Reinnervation of muscle fiber basal lamina after removal of myofibers. Differentiation of regenerating axons at original synaptic sites. J. Cell Biol., 78: 176–198.PubMedCrossRefGoogle Scholar
  17. Saxod, R., 1978, Development of cutaneous sensory receptors in birds, in: M. Jacobson (ed), “Handbook of Sensory Physiology. IX. Development of Sensory System,” Springer, Berlin, pp. 337–418.CrossRefGoogle Scholar
  18. Shanta, T.R., and Bourne, B.H., 1968, The perineural epithelium, in: G.H. Bourne (ed), “The Structure and Function of Nervous Tissue,” Vol. 1, Academic Press, New York, 379–459.Google Scholar
  19. Tohyama, K., and Ide, C., 1984, The localization of laminin and fibronectin on Schwann cell basal lamina, Arch. Histol. Jap., 47, 519–522.PubMedCrossRefGoogle Scholar
  20. Vracko, R., 1972, Significance of basal lamina for regeneration of injured lung, Virchow Arch. (Pathol. Anat.), 355: 264–274.CrossRefGoogle Scholar
  21. Vracko, R., and Benditt, E.P., 1972, Basal lamina: The scaffold for orderly cell replacement, J. Cell Biol., 55, 406–419.PubMedCrossRefGoogle Scholar
  22. Zelena, J., 1984, Multiple axon terminals in reinnervated Pacinian corpuscles of adult rat, J. Neurocytol., 13, 665–684.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Chizuka Ide
    • 1
  1. 1.Department of AnatomyIwate Medical University, School of MedicineMorioka 020Japan

Personalised recommendations