Antibiotic-Containing Polyurethanes for the Prevention of Foreign-Body Infections
The incorporation of antibiotics (clindamycin, flucloxacillin, vancomycin) into polyurethanes to obtain drug delivery devices is described. The drug release kinetics of the films was determined in a modified bioassay. Polyurethane films containing clindamycin or vancomycin show a high initial release rate, and drug release is observed up to 5–7 days. Flucloxacillin-containing polymer films exhibit a more constant drug release profile with a drug release lasting at least for 15 days or longer. Radiation methods as well as glow discharge techniques were applied to antibiotic-loaded films in order to modify drug release characteristics. Effectiveness of the devices to prevent adhesion or to kill adherent bacteria was tested with in vitro bacterial adhesion experiments. Initial adhesion to the antibiotic-loaded films is not prevented, but in case of clindamycin- and flucloxacillin-containing films a considerable reduction of adherent viable cells from 105 to 101 is observed.
KeywordsCatheter Acetone Agar Helium Vancomycin
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