Abstract
Bradykinin and kallidin are released in blood and tissues by several stimuli and produce a variety of local effects by acting as autacoids. Some of these effects appear to be initiated by stimulation of afferent fibers and produce tissue responses of reflex nature. Indeed, bradykinin has been shown to be the most active endogenous agent to produce pain sensation when applied to blister base in man (1, 2, 3): this peptide has also been found to activate nociceptive responses in laboratory animals (Table 1), among others the writhing syndrome in the mouse (4, 5) the vocalization response in the dog (6), the reflex head flexion reaction in the rat (7, 8) and other painful responses (see Garcia-Leme (9) and Clark (50), for reviews). In other in vivo assays in the dog, the cat and the rat, bradykinin has been used to stimulate sensory fibers and activate cardiovascular reflexes. Thus, Lombardi et al. (10) and Malliani (11) have applied bradykinin in the coronary arteries of anesthetized cats to activate reflex responses of the sympathetic and vagal cardiac sensory nerves. They have observed an increase of the left ventricular and of the systemic pressures, together with a significant increase in the sympathetic efferent impulses.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D. Armstrong, Pain, in: “Handbook of Experimental Pharmacology, Vol. 25, Bradykinin, Kallidin and Kallikrein, E.G. Erdös, ed., Springer-Verlag, Berlin, pp.434–481 (1970).
D.C. Manning, A.A. Khan, J.N. Campbell, R.A. Meyer and S.N. Raja, Bradykinin induced cutaneous pain is independent of wheal and flare, Pain (Suppl.) 4:S16 (abstr.) (1987).
E.T. Whalley, S. Clegg, J.M. Stewart and R.J. Vavrek, The effect of kinin agonists and antagonists on the pain response of the human blister base, Naunyn Schmeideberg’s Arch. Pharmacol., 336:652 (1987)
J.M. Emerle and J.E. Shanaman, Bradykinin writhing: a method for measuring analgesia, Pro. Soc. Exp. Biol. Med. 114:680 (1963).
L.R. Steranka, C.J. Detlaas, R.J. Vavrek, J.M. Stewart, S.J. Enna and S.H. Snyder, Antinociceptive effects of bradykinin antagonists, Eur. J. Pharmacol., 136:261 (1987).
G.D. Potter, F. Guzman and R.K.S. Lim, Visceral pain evoked by intra-arterial injection of substance P, Nature, 193:983 (1962).
G. Deffenu, L. Pegrassi and B. Lumachi, The use of bradykinin-induced effects in rats as an assay for analgesic drugs, J. Pharm. Pharmacol., 18:135 (1966).
L.R. Steranka, D.C. Manning, C.J. DeHaas, J.W. Ferkany, S.A. Borosky, J.R. Connor, R.J. Vavrek, J.M. Stewart and S.H. Snyder, Bradykinin as a pain mediator: Receptors are localized to sensory neurons and antagonists have analgesic actions, Proc. Natl. Acad. Sci., 85:3245 (1988).
J. Garcia-Leme, Bradykinin-System, in: “Handbook of Experimental Pharmacology”, Vol. 50/1, J.R. Vane, S.H. Ferreira, eds. Inflammation, Springer Verlag, Berlin (1978).
F. Lombardi, C.P. Patton, P.D. Bella, M. Pagani and A. Malliani, Cardiovascular and sympathetic responses reflexly elicited through the excitation with bradykinin of sympathetic and vagal cardiac sensory endings in the cat, Circulation Res., 57:65 (1982).
A. Malliani, Cardiovascular sympathetic afferent fibers, Rev. Physiol. Biochem. Pharmacol., 94:11 (1982).
D.G. Baker, H.M. Coleridge, J.C.G. Coleridge and T. Nerdrum, Search for a cardiac nociceptor: stimulation by bradykinin of sympathetic afferent nerve endings in the heart of the cat, J. Physiol. London, 306:519 (1980).
J. Staszewska-Barzak, S.H. Ferreira and J.R. Vane, An excitatory nociceptive cardiac reflex elicited by bradykinin and potentiated by prostaglandins and myocardial ischaemia, Card. Res., 10:314 (1980)
J. Staszewska-Barzak, S.H. Ferreira and J.R. Vane, An excitatory nociceptive cardiac reflex elicited by bradykinin and potentiated by prostaglandins and myocardial ischaemia, Card. Res., 10:314 (1980)
Y. Uchida and S. Murao, Bradykinin-induced excitation of afferent cardiac sympathetic nerve fibers, Jap. Heart J., 15:84 (1974).
J.C. Longhurst, M.P. Kaufman, G.A. Ordway and T.J. Mush, Effects of capsaicin and bradykinin on endings of afferent fibers from abdominal visceral organs, Am. J. Physiol., 245:R552 (1984).
F. Rioux, H. Bachelard, S. St-Pierre and J. Barabé, Epicar-dial application of bradykinin elicits pressor effects and tachycardia in guinea-pigs, Possible mechanisms, Peptides, 8:863 (1987).
P. Geppetti, C.A. Maggi, F. Perretti, S. Frilli and S. Manzini, Simultaneous release by bradykinin of substance P and calcitonin gene-related peptide immunoreactivities from capsaicin-sensitive structures in guinea-pig heart, Br. J. Pharmacol., 94:288 (1988).
M.P. Kaufman, H.M. Coleridge, J.C.G. Coleridge and D.G. Baker, Bradykinin stimulates afferent vagal C-fibres in intrapulmonary airways of dogs, J. Appl. Physiol., 48:511 (1980).
J.C.G. Coleridge and H.M. Coleridge, Afferent vagal C-fibre innervation of the lungs and airways and its functional significance, Rev. Physiol. Biochem. Pharmacol., 99:1 (1984).
B.G. Simonsson, B.E. Skoogh, N.P. Bergh, R. Andersson and N. Svedmyr, In vivo and in vitro effect of bradykinin on bronchial motor tone in normal subjects and patients with airways obstruction, Respiration, 30:378 (1973).
R.W. Fuller, C.M.S. Dixon, F.M.C. Cuss and P.I. Barnes, Bradykinin-induced bronchoconstriction in man: mode of action, Am. Rev. Respir. Dis., 135:176 (1987).
P.J. Barnes, Airway neuropeptides and asthma, TIPS, 8:24 (1987).
R.K.S. Lim, D.G. Miller, F. Guzman, D.W. Rodgers, R.W. Rogers, S.K. Wang, P.Y. Chao and T.Y. Shih, Pain and analgesia evaluated by the intraperitoneal bradykinin-evoked pain method in man, Clin. Pharmacol. Ther., 8:521 (1967).
A. Nasjletti and K.U. Malik, Relationships between the kal-likrein-kinin and prostaglandin systems, Life Sci., 25:99 (1979).
D. Regoli, J. Barabé and W.K. Park, Receptors for bradykinin in rabbit aortae, Can. J. Physiol. Pharmacol., 55:855 (1977).
D. Regoli, N.E. Rhaleb, S. Dion and G. Drapeau, Bradykinin receptors: B1 and B2 and what else? TIPS, in press (1990).
C.P. Sung, A.J. Arleth, K. Shikano and B.A. Berkowitz, Characterization and function of bradykinin receptors in vascular endothelial cells, J. Pharmacol. Exp. Ther., 247:8 (1988).
P. D’Orléans-Juste, G. de Nucci and J.R. Vane, Kinins act on B1 or B2 receptors to release conjointly endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells, Br. J. Pharmacol., 96:920 (1989).
F. Marceau, A. Lussier, D. Regoli and J.-P. Giroud, Pharmacology of kinins: their relevance to tissue injury and inflammation, Gen. Pharmacol., 14:209 (1983).
K.U. Malik and A. Nasjletti, Attenuation by bradykinin of adrenergically-induced vasoconstriction in the isolated perfused kidney of the rabbit: relationship to prostaglandin synthesis, Br. J. Pharmacol., 67:269 (1979).
F. Lombardi, P.D. Bella, R. Casati and A. Malliani, Effects of intracoronary administration of bradykinin on the impulse activity of afferent sympathetic unmyelinated fibers with left ventricular endings in the cat, Circulation Res., 48:69 (1981).
J. Barabé, F. Marceau, B. Thériault, J.-N. Drouin and D. Regoli, Cardiovascular actions of kinins in the rabbit, Can. J. Physiol. Pharmacol., 57:78 (1979.
S.H. Ferreira and J.R. Vane, The disappearance of bradykinin and eledoisin in the circulation of vascular beds of the cat, Br. J. Pharmacol., 30:417 (1967).
G. Bönner, S. Preis, V. Shunk and D. Iwersen, Hemodynamic effects of kinins and their role in blood pressure regulation in “The Kallikrein-Kinin System in Health and Disease”, H. Fritz et al. eds., Limbach-Verlag, Braunschweig, Germany (1989).
O.A. Carretero and A.G. Scicli, Kinins paracrine hormone, in “The Kallikrein-Kinin System in Health and Disease”, H. Fritz et al. eds., Limbach-Verlag, Braunschweig, Germany (1989).
A. Dray and M.N. Perkins, Bradykinin activates peripheral capsaicin-sensitive fibres via a second messenger system, Agents and Actions, 25:214 (1988).
P.M. Dunn and H.P. Rang, Bradykinin activation of primary afferent terminals in the neonate rat spinal cord in vitro, Br. J. Pharmacol., 98:827P (abs.)(1989).
T. Kudo, H.L. Chang, M. Kuroi, S. Wakisaka, M. Akai and R. Inoki, Influences of bradykinin and substance P on the Metenkephalin-like peptide content in the rat incisor pulp, Neuropeptides, 7:399 (1986).
C.A. Maggi, R. Patacchini, P. Santicioli, P. Geppetti, R. Cecconi, S. Giuliani and A. Meli, Multiple mechanisms in the motor response of the guinea-pig isolated urinary bladder to bradykinin, Br. J. Pharmacol., 98:619 (1989).
T. Griesbacher and F. Lembeck, Effect of bradykinin antagonists on bradykinin-induced plasma extravasation, venocon-striction, prostaglandin E2 release, nociceptor stimulation and contraction of the iris sphincter muscle in the rabbit, Br. J. Pharmacol., 92:333 (1987).
J.M. Butter and B. Hammond, Neurogenic responses of the eye injury: effect of sensory denervation on the responses of the rabbit eye to bradykinin and prostaglandin E1, Trans. Ophthalmol. Soc. U.K., 97:668 (1977).
H. Juan and F. Lembeck, Action of peptides and other algesic agents on paravascular pain receptor of the isolated perfused rabbit ear, Naunyn-Schmiedebergs Arch. Pharmacol. 283:151 (1974).
T. Doi, A. Akaike, M. Ohashi, M. Satoh and H. Takaji, Bradykinin-induced flexor reflex of rabbit hindlimb for comparing analgesics, Jap. J. Pharmacol., 26:634 (1976).
W.M. Yau, J.A. Dorsett and M.L. Youther, Bradykinin releases acetylcholine from myenteric plexus by a prostaglandin-mediated mechanism, Peptides, 7:289 (1986).
O. Laneuville and R. Couture, Bradykinin analogue blocks bradykinin-induced inhibition of a spinal nociceptive reflex in the rat, Eur. J. Pharmacol., 137:281 (1987).
T.N. Bhalla, S.N. Sinha, R.P. Kohli and K.P. Bhargava, A comparative study of the writhing response induced by phenylquinone, bradykinin and aconitine for the assessment of analgesic agents, Jap. J. Pharmacol., 23:609 (1973).
S.H. Ferreira, S. Moncada and J.R. Vane, Potentiation by prostaglandins of the nociceptive activity of bradykinin in the dog knee joint, Br. J. Pharmacol., 50:461P (abst.)(1974).
P. Devillier, M. Renoux, G. Drapeau and D. Regoli, Histamine release from rat peritoneal mast cells by kinin antagonists, Eur. J. Pharmacol., 149:137 (1988).
W.C. Clark, Kinins and the peripheral and central nervous system, Handb. Exp. Pharmacol. 25 (suppl.):311 (1979).
P. Devillier, G. Drapeau, M. Renoux and D. Regoli, Role of the N-terminal arginine in the histamine-releasing activity of substance P, bradykinin and related peptides, Eur. J. Pharmacol., 168:53 (1989).
N.E. Rhaleb, S. Télémaque, N. Rouissi, S. Dion, D. Jukic, G. Drapeau and D. Regoli, Structure-activity studies of bradykinin and related peptides. II. Antagonists., Br. J. Pharmacol., (submitted)(1990).
D. Regoli, G. Drapeau, P. Rovero, S. Dion, N.-E. Rhaleb, J. Barabé, P. D’Orléans-Juste and P. Ward, Conversion of kinins and their antagonists into B., receptor activators and blockers in isolated vessels, Eur. J. Pharmacol., 127:219 (1986).
D. Regoli, N.-E. Rhaleb, G. Drapeau, S. Dion, C. Tousignant and P. D’Orléans-Juste, Basic pharmacology of kinins in: “Pharmacologic receptors and other mechanisms, Kinins V.,” Plenum Press, New York (1989).
D. Regoli, N.-E. Rhaleb, G. Drapeau, S. Dion, Kinin receptor subtypes, J. Cardiovasc. Pharmacol., (in press) (1990).
R.J. Vavrek and J.M. Stewart, Competitive antagonists of bradykinin, Peptides, 6:161 (1985).
J.M. Stewart and R.J. Vavrek, Design of bradykinin antagonists in: Peptides, Chemistry and Biology. Proceedings of the Tenth American Peptide symposium, G.R. Marshall ed., Escom Leiden (1988).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Regoli, D., Rhaleb, NE., Rouissi, N., Tousignant, C., Jukic, D., Drapeau, C. (1991). Activation of Sensory Nerves by Kinins: Pharmacologic Tools for Studying Kinin Receptors. In: Costa, M., Surrenti, C., Gorini, S., Maggi, C.A., Meli, A. (eds) Sensory Nerves and Neuropeptides in Gastroenterology. Advances in Experimental Medicine and Biology, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0744-8_6
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0744-8_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0746-2
Online ISBN: 978-1-4899-0744-8
eBook Packages: Springer Book Archive