Abstract
The anticancer drug cis-diamminedichloroplatinum(II) (cis-DDP or cisplatin), is believed to kill cells by blocking DNA replication or transcription (Roberts and Thomson, 1979; Sorenson and Eastman, 1988a, b). cis-DDP-DNA adducts have been shown to block DNA replication in vitro (Pinto and Lippard, 1985b; Heiger-Bernays et al., 1990) and in vivo (Harder and Rosenberg, 1970; Howie and Gale, 1970; Ciccarelli et al., 1985). Similar recent studies have shown that selected platinum adducts also inhibit RNA polymerases (Corda et al., 1991).
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Donahue, B.A., Bellon, S.F., Lippard, S.J., Essigmann, J.M. (1991). A Protein from Mammalian Cells that Recognizes Platinated DNA. In: Howell, S.B. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0738-7_23
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DOI: https://doi.org/10.1007/978-1-4899-0738-7_23
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