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Pharmacological Profile, Pharmacokinetics and Biotransformation of the 5-Lipoxygenase Inhibitor FLM 5011

  • Tankred Schewe
  • Hartmut Kühn
  • Sylva Loose
  • Lothar Lücke
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

The implication of lipoxygenase-mediated pathways of polyenoic fatty acid metabolism in inflammation, bronchial asthma and other diseases is today generally accepted. Nevertheless the precise role of lipoxygenase metabolites, in particular their interaction with other groups of inflammatory mediators, is yet far from clear. Specific inhibitors of lipoxygenases are valuable tools to gain deeper insight into the biological role of lipoxygenases and their reaction products.

Keywords

Arachidonic Acid Hydroxamic Acid Urinary Metabolite Lipoxygenase Inhibitor Dibenzoyl Peroxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Tankred Schewe
    • 1
  • Hartmut Kühn
    • 1
  • Sylva Loose
    • 1
  • Lothar Lücke
    • 2
  1. 1.Institute of BiochemistryHumboldt University, Medical School (Charité)BerlinGermany
  2. 2.Chemische und Pharmazeutische Fabriken Fahlberg-List GmbHMagdeburgGermany

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