Abstract
Hydrolysis of phosphatidylinositol 4,5-biphosphate (PtdIns4,5P2) resulting in the generation of two “putative second messengers”: inositol 1,4,5-triphosphate (Ins1,4,5P3) and diacylglycerol (DAG) is now recognized as an essential pathway for generating modulators of a wide variety of hormonal signals (Hokin, 1985; Berridge, 1984; Nishizuka, 1984). The replenishment of cellular PtdIns4,5P2 depends on the sequential phosphorylation of the 4- and 5-hydroxy groups of the inositol ring by PtdIns and PtdInsP kinases respectively, implying that the mode of phosphorylation of the phosphoinositides is an important aspect in the generation of molecules involved in the signal transduction systems. An outline of the inositol phospholipid cascade showing the conventional pathway as well as the putative 3-kinase pathway resulting in phosphatidylinositol 3,4,5-trisphosphate (PtdIns3,4,5P3) is shown in Fig. 1.
An Outline of the Cellular Mechanisms Involved in Receptor-Coupled Transmembrane Signalling
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Ziboh, V.A., Tang, W. (1991). Eicosanoid/Signal Transduction Interactions: Evidence of Two Induced Pathways of Phosphoinositide Biosynthesis by LTB4 in Cultured Human Epidermal Cells. In: Bailey, J.M. (eds) Prostaglandins, Leukotrienes, Lipoxins, and PAF. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0727-1_15
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