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Leukocyte-Mediated Endothelial Injury

  • Robert K. Winn
  • Charles L. Rice
  • Nicholas B. Vedder
  • William J. Mileski
  • John M. Harlan

Abstract

The inflammatory response is characterized by leukocyte adherence to the vessel wall and subsequent infiltration of tissue by emigrated leukocytes.1 Leukocytes contain or are capable of producing a number of products that can potentially cause cell injury or modify cell function (reviewed in Ref. 2). Consequently, many investigators have proposed a causal relationship between leukocyte accumulation at sites of inflammation or immune reaction and associated vascular and tissue injury. Leukocyte-mediated injury of vascular endothelium as an “innocent bystander” has been implicated in the pathogenesis of a wide variety of clinical disorders some of which are listed in Table 1.

Keywords

Reperfusion Injury Vascular Injury Hemorrhagic Shock Allograft Rejection Leukocyte Adherence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Robert K. Winn
    • 1
  • Charles L. Rice
    • 2
  • Nicholas B. Vedder
    • 2
  • William J. Mileski
    • 2
  • John M. Harlan
    • 3
  1. 1.Departments of Surgery and Physiology-BiophysicsUniversity of WashingtonSeattleUSA
  2. 2.Department of SurgeryUniversity of WashingtonSeattleUSA
  3. 3.Department of MedicineUniversity of WashingtonSeattleUSA

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