Response of Human Vascular Cells to Viral Infection

  • Nicholas A. Kefalides


Injury to blood vessel cells has been implicated in the development of a variety of vascular disorders including atherosclerosis,2,15 disseminated intravascular coagulation,9 and immune vasculitis.56 Endothelial cell (EC) injury can arise from a variety of causes including hemodynamic stress,64 mechanical trauma,65 hypercholesterolemia,57 infectious agents,16,49,54 oxygen33 and other chemical agents such as homocysteine.74 Renewed interest in the relationship between vascular injury due to viral infection and atherosclerosis stems from recent observations which demonstrated that virus particles, virus antigens, and virus DNA can be detected in vascular lesions of chickens11,49 and humans4,23,48,76 with atherosclerosis. Viruses may produce vascular injury by mechanisms other than direct invasion of endothelium. Antigen-antibody complexes involving hepatitis B surface antigen have been isolated from the sera of some patients with periarteritis nodosa.19 Tumor formation as a result of viral infection is another possible mechanisms by which viruses may induce vascular disease as is the case with cytomegalovirus and Kaposi’s sarcoma.22 At the time our laboratory began investigating the in vitro interaction between virus and EC,8,17,45 few such studies had been reported.1,20 Since the last review, Visser et al.72 reported enhanced thrombin generation and platelet binding on herpes simplex virus (HS V)-infected endothelium and Dunn and Spear80 demonstrated that cell surface heparan sulfate proteoglycan serves as the initial receptor for both HSV-1 and HSV-2 in HEp-2 cells. In this report I essentially summarize our published work as well as recently published work by other investigators.


Herpes Simplex Herpes Simplex Virus Type Lithium Chloride Endothelial Cell Culture Bovine Endothelial Cell 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Nicholas A. Kefalides
    • 1
    • 2
  1. 1.Connective Tissue Research Institute and Department of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Connective Tissue Research Institute and Department of MedicineUniversity City Science CenterPhiladelphiaUSA

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