Abstract
The electron microscopic studies of N. Simionescu and collaborators17–19 have clearly shown that the endothelium in the three basic segments of the microcirculation—arterioles, capillaries, and venules—differs in terms of ultrastructure and permeability. Segmental differences are obvious also in the inflammatory response. Indeed, those chemical mediators that increase microvascular permeability do so by affecting selectively the permeability of the venules; this was established by using a method that selectively marks leaky segments of the microcirculation, namely vascular labeling.13 A clue to this selectivity for the venules was provided by Heltianu et al. 5 who showed that the endothelium of these vessels is especially rich in histamine receptors. Another difference between capillary and venular endothelium is that the latter is able to contract in vivo under the stimulus of inflammatory mediators7; rather than reducing the caliber of the vessel, this contraction produces gaps between the endothelial cells, allowing the escape of fluid.7,14
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References
Cotran, R. S., 1967, Studies on inflammation. Ultrastructure of the prolonged vascular response induced by Clostridium oedematiens toxin, Lab. Invest. 17:39–60.
Cotran, R. S., and Majno, G., 1964, A light and electron microscopic analysis of vascular injury, Ann. N.Y. Acad. Sci. 116:750–763.
Cotran, R. S., and Majno, G., 1964, The delayed and prolonged vascular leakage in inflammation. I. Topography of the leaking vessels after thermal injury. Am. J. Pathol. 45:261–281.
Cuénoud, H. F., Joris, I., Langer, R. S., and Majno, G., 1987, Focal arteriolar insudation. A response of arterioles to chronic nonspecific irritation, Am. J. Pathol. 127:592–604.
Heltianu, C., Simionescu, M., and Simionescu, N., 1982, Histamine receptors of the microvascular endothelium revealed in situ with a histamine-ferritin conjugate: Characteristic high-affinity binding sites in venules, J. Cell Biol. 93:357–364.
Hurley, J. V., and Jago, M. V., 1976, Delayed and prolonged vascular leakage in inflammation: The effects of dehydromonocrotaline on blood vessels in the rat cremaster, Pathology 8:7–20.
Joris, I., Majno, G., Corey, E. J., and Lewis, R. A., 1987, The mechanism of vascular leakage induced by leukotriene E4. Endothelial contraction, Am. J. Pathol. 126:19–24.
Joris, I., Cuénoud, H. F., Doern, G. V., Underwood, J. M., and Majno, G., 1990, Capillary leakage in inflammation: A study by vascular labeling, Am. J. Pathol. 137:1353–1363.
Krizek, T. J., and Rabson, M. C., 1975, Evolution of quantitative bacteriology in wound management, Am. J. Surg. 130:579–584.
Lenette, E. H., Balows, A., Hausier, W. J., and Shadomy, H. J. (eds.), 1985, Manual of Clinical Microbiology, fourth edition, American Society for Microbiology, Washington, D. C.
Lin, S.-J., Jan, K.-M., Weinbaum, S., and Chien, S., 1989, Transendothelial transport of low density lipoprotein in association with cell mitosis in rat aorta, Arteriosclerosis 9:230–236.
Majno, G., and Palade, G. E., 1961, Studies on inflammation. I. The effect of histamine and serotonin on vascular permeability: An electron microscopic study, J. Biophys. Biochem. Cytol. 11:571–605.
Majno, G., Palade, G. E., and Schoefl, G. I., 1961, Studies on inflammation. II. The site of action of histamine and serotonin along the vascular tree: A topographic study, J. Biophys. Biochem. Cytol. 11: 607–626.
Majno, G., Shea, S. M., and Leventhal, M., 1969, Endothelial contraction induced by histamine-type mediators. An electron microscopic study, J. Cell Biol. 42:647–672.
Persson, C. G. A., and Svensjo, E., 1985, Vascular responses and their suppression: Drugs interfering with venular permeability, in: The Pharmacology of Inflammation (I. L. Bonta, M. A. Bray, and M. J. Parnham, eds.), Elsevier, Amsterdam, pp. 71–82.
Schoefl, G. I., 1963, Studies on inflammation. III. Growing capillaries: Their structure and permeability, Virchows Arch. Pathol. Anat. 337:97–141.
Simionescu, N., Simionescu, M., and Palade, G. E., 1978, Open junctions in the endothelium of the postcapillary venules of the diaphragm, J. Cell Biol. 79:27–44.
Simionescu, N., Simionescu, M., and Palade, G. E., 1978, Structural basis of permeability in sequential segments of the microvasculature of the diaphragm. I. Bipolar microvascular fields, Microvasc. Res. 15: 1–16.
Simionescu, N., Simionescu, M., and Palade, G. E., 1978, Structural basis of permeability in sequential segments of the microvasculature of the diaphragm. II. Pathways followed by microperoxidase across the endothelium, Microvasc. Res. 15:17–36.
Wilhelm, D. L., 1973, Chemical mediators, in: The Inflammatory Process, Vol. II (B. W. Zweifach, L. Grant, and R. T. McCluskey, eds.), Academic Press, New York, pp. 251–301.
Willms-Kretschmer, K., Flax, M. H., and Cotran, R. S., 1967, The fine structure of the vascular response in hapten-specific delayed hypersensitivity and contact dermatitis, Lab. Invest. 17:334–349.
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Joris, I., Cuénoud, H.F., Doern, C.V., Underwood, J.M., Majno, G. (1992). Endothelial Permeability in Inflammation. In: Simionescu, N., Simionescu, M. (eds) Endothelial Cell Dysfunctions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0721-9_14
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DOI: https://doi.org/10.1007/978-1-4899-0721-9_14
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