Abstract
Bilirubin, the end product of heme catabolism, is generally regarded as toxic and highly fatal in newborn infants and fulminant hepatitis. Bilirubin encephalopathy (kernicterus) is usually considered to be caused by the entry of circulating, free (albumin-unbound), unconjugated bilirubin into the cerebral tissue.1,2 Bilirubin conjugation with glucuronic acid takes place in the liver and the process is impaired in liver diseases. Our tactic for the treatment of jaundice is to decompose toxic bilirubin by the enzyme bilirubin oxidase, and for that purpose the enzyme is made into a polymer conjugate to improve its pharmacological properties.3
Keywords
- Degradation Product
- Obstructive Jaundice
- Neonatal Jaundice
- Unconjugated Bilirubin
- Cyanuric Chloride
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
G. B. Odell, J. Clin. Invest. 38, 823 (1959).
J. Bernstein and B. H. Landing, Am. J. Pathol. 40, 371 (1962).
M. Kimura, Y. Matsumura, Y. Miyauchi, and H. Maeda, Proc. Soc. Exp. Biol. Med. 188, 364 (1988).
M. Kimura, Y. Matsumura, T. Konno, Y. Miyauchi, and H. Maeda, Proc. Soc. Exp. Biol. Med. 195, 64 (1990).
R. Zeterstrom and L. Ernster, Nature 15, 1335 (1956).
M. G. Mustafa, M. L. Cowger and T. E. King, Biochem. Biophys. Res. Commun. 29, 661 (1967).
M. G. Mustafa, M. L. Cowger, and T. E. King, J. Biol. Chem. 244, 6463 (1969).
M. E. D. Notter and J. W. Kending, Exp. Neurol. 94, 670 (1986).
L. F. Rasmussen and R. P. Wennberg, Res. Commun. Chem. Pathol. Pharmacol. 3, 567 (1972).
O. Schiff, G. Chan, and M. J. Poznansky, Pediatr Res. 19, 908 (1972).
M. M. Thaler, Nat. New Biol. 230, 218 (1971).
M. L. Cowger, Biochem. Med. 5, 1 (1971).
I. Miler, M. Indrova, J. Bubenik, and J. Vondracek, Folia Microbiol. (Praha) 30, 272 (1985).
I. N. Dubin, B. Czernobilsky, and B. Herbst, Arch. Pathol. 79, 232 (1965).
R. Kaul, V. K. Bajpai, A. C. Shipstone, H. K. Kaul, and C. R. K. Murti, Exp. Mol. Pathol. 34, 290 (1981).
C. L. Kapoor, C. R. Krishna-Murti, and P. C. Bajpai, Indian J. Med. Res. 60, 918 (1972).
S. O. Lie and D. Brantlid, Scand. J. Lab. Invest. 26, 37 (1970).
S. Murao and N. Tanaka, Agric. Biol. Chem. 45, 2283 (1981).
S. Murao and N. Tanaka, Agric. Biol. Chem. 46, 2031 (1982).
S. Murao and N. Tanaka, Agric. Biol. Chem. 46, 2499, 1982).
N. Tanaka and S. Murao, Agric. Biol. Chem. 49, 843 (1985).
C. Sung, A. Lavin, A. Klibanov, and R. Langer, Trans. Am. Soc. Artif. Internal Organs 31, 264 (1985).
A. Lavin, C. Sung, A. M. Klibanov, and R. Langer, Science 230, 543 (1985).
H. Maeda, T. Matsumoto, T. Konno, K. Iwai, and M. Ueda, J. Protein Chem. 3, 181 (1984).
H. Maeda, M. Ueda, T. Morinaga, and T. Matsumoto, J. Med. Chem. 28, 455 (1985).
Y. Kamisaki, H. Wada, T. Yagura, A. Matsushita, and Y. Inada, J. Pharmacol. Exp. Ther. 216, 410 (1981).
Y. Ashihara, T. Kono, S. Yamazaki, and Y. Inada, Biochem. Biophys. Res. Commun. 83, 385 (1987).
P S. Pyatak, A. Abuchowski, and F. F. Davis, Res. Comm. Chem. Pathol. Pharmacol. 29, 113–127 (1980).
M. S. Hershfield, R. H. Buckley, M. L. Greenberg, A. L. Melton, R. Schiff, C. Hatem, J. Kurzberg, M. L. Markert, R. H. Kobayashi, A. L. Kobayashi, and A. Abuchowski. N. Engl. J. Med. 316, 589 (1987).
N. V. Katre, M. J. Knauf, and W. J. Laird, Proc. Natl. Acad. Sci. U.S.A. 84, 1487 (1987).
K. Sugita, T. Sato, A. Fuse, and H. Nakajima, Biol. Neonate 49, 255 (1986).
H. Tsuda, H. Maeda, and S. Kishimoto, Br. J. Cancer 43, 793 (1981).
F. M. Veronase, R. Largajolli, E. Boccu, C. A. Benassi, and O. Schiavon, Appl. Biochem. Biotech. 11, 141 (1985).
D. J. Hanatowich, W. W. Layne, and R. L. Childs, Int. J. Appl. Radiat. Isot. 33, 327 (1982).
J. J. Munoz, Methods Immunol. Immunochem. 3, 146 (1970).
I. Diamond, and R. Schmid, J. Clin. Invest. 45, 678 (1966).
R. Broderson, J. Pediatrics 96, 349 (1980).
S. O. Lie and D. Brantlid, J. Scand. Lab. Invest. 26, 37 (1970).
C. S. Simionatto, K. E. Anderson, G. S. Drummond, and A. Kappas, J. Clin. Invest. 75, 513 (1985).
J. L. Golan, K. J. C. Dallinger, and B. Billing, Clin. Sci. Mol. Med. 54, 381 (1978).
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© 1992 Springer Science+Business Media New York
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Maeda, H., Kimura, M., Sasaki, I., Hirose, Y., Konno, T. (1992). Toxicity of Bilirubin and Detoxification by PEG-Bilirubin Oxidase Conjugate. In: Harris, J.M. (eds) Poly(Ethylene Glycol) Chemistry. Topics in Applied Chemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0703-5_11
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DOI: https://doi.org/10.1007/978-1-4899-0703-5_11
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