The Neocortex pp 175-183 | Cite as

Ontogeny and Structure of the Radial Goal Fiber System of the Developing Murine Cerebrum

  • Verne S. CavinessJr.
  • Jean-Paul Mission
  • Takao Takahashi
  • Jean-Francois Gadisseux
Chapter
Part of the NATO ASI Series book series (NSSA, volume 200)

Abstract

Neurons of cerebral cortical structures undergo their terminal divisions in a periventricular generative epithelium, the ventricular zone (VZ: Boulder Committee, 1970; Sidman and Rakic, 1973). Its final mitosis completed, the young cell must migrate centrifugally to achieve its position in the developing cortex. It is thought that the cell is guided in its migration by contact with the surfaces of specialized cells of astroglial lineage, the radial glial cells (Rakic 1972,1988; Nowakowski and Rakic, 1979; Misson et al., 1989a). A monopolar radial glial form, the Bergmann glial cell, is thought to serve an analogous role as guide to neuronal migration in the developing cerebellar cortex (Rakic, 1971; Edmondson and Hatten, 1987). These bipolar and monopolar radial astroglial forms are thus essential to cellular interactions of fundamental significance for histogenesis of cortical structures of the central nervous system.

Keywords

Migration Attenuation Aldehyde Assure Thymidine 

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Verne S. CavinessJr.
    • 1
  • Jean-Paul Mission
    • 1
    • 2
  • Takao Takahashi
    • 1
  • Jean-Francois Gadisseux
    • 1
    • 3
  1. 1.Department of Neurology, Developmental NeurobiologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  2. 2.Department of Developmental NeurobiologyUniversity of LiegeBelgium
  3. 3.Developmental Neurology UnitUniversity of Louvain Medical SchoolBrusselsBelgium

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