Methionine Enkephalin: Immunomodulator in Normal Volunteers (in Vivo)

  • N. P. Plotnikoff
  • G. C. Miller
  • S. Solomon
  • R. E. Faith
  • L. Edwards
  • A. J. Murgo


The enkephalin, methionine enkephalin (met-enkephalin) was originally discovered to be one of the endogenous ligands for morphine receptors (Hughes et al., 1975; Simontov and Snyder, 1976). However, Plotnikoff et al., (1976) discovered anti-depressant, anti-anxiety, and anti-convulsant effects of the enkephalins, identifying a much broader spectrum of pharmacological effects than originally anticipated.


Natural Killer Natural Killer Cell Natural Killer Cell Activity Opiate Receptor Terminal Complex 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • N. P. Plotnikoff
    • 1
  • G. C. Miller
    • 2
  • S. Solomon
    • 2
  • R. E. Faith
    • 1
  • L. Edwards
    • 3
  • A. J. Murgo
    • 1
  1. 1.Departments of Pharmacology, School of MedicineOral Roberts UniversityTulsaUSA
  2. 2.Immuno-Diagnostics LabTulsaUSA
  3. 3.Departments of Medicine, School of MedicineOral Roberts UniversityTulsaUSA

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