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Obstipation

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Book cover Handbook of Hematologic and Oncologic Emergencies

Abstract

Obstipation is defined as “extreme” constipation, meaning practically an interruption of the gastrointestinal transit. Acute obstipation may arise de novo or may complicate an already chronic state of constipation. Obstipation in cancer patients may be due to the mechanical or metabolic effect of the tumor, may result from the use of antineoplastic drugs or of other drugs, or may be due to unrelated causes. Table 1 summarizes the causes of obstipation that arises in cancer patients.

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References

  1. Lo AM, Evans WE, Carey LC: Review of small bowel obstruction at Milwaukee County General Hospital. Am J Surg 111: 884, 1966.

    Article  PubMed  CAS  Google Scholar 

  2. Sise JG, Crichlow RW: Obstruction due to malignant tumors. Semin Oncol 5: 213–224, 1978.

    PubMed  CAS  Google Scholar 

  3. McNeil JE: Mechanism of obstruction in carcinoid tumors of the small intestine. Am J Clin Pathol 56: 452, 1971.

    Google Scholar 

  4. Glass RL, Le Duc RJ: Small intestinal obstruction from peritoneal carcinomatosis. Am J Surg 125: 316, 1973.

    Article  PubMed  CAS  Google Scholar 

  5. Ulin AW, Delement FA, James PM: Large bowel obstruction due to carcinoma. Am Fam Physician 3: 79, 1971.

    PubMed  CAS  Google Scholar 

  6. Glenn F, McSherry CK: Obstruction and perforation in colorectal cancer. Ann Surg 173: 983, 1971.

    Article  PubMed  CAS  Google Scholar 

  7. Welsch JP, Donaldson GA: Management of severe obstruction of the large bowel due to malignant disease. Am J Surg 127: 492, 1974.

    Article  Google Scholar 

  8. Thurtle OA, Allen AP, Walters MT, Kitchen JV, Smith CL, Cawley MD: Intractable constipation in malignant phaeochromocytoma: Combined treatment with adrenergic blockade and cholinergic drugs. J R Soc Med 77: 327–328, 1984.

    PubMed  CAS  Google Scholar 

  9. Short IA, Padfield PL: Malignant pheochromocytoma with severe constipation and myocardial necrosis. Br Med J 20: 793–794, 1976.

    Article  Google Scholar 

  10. Hume DM: Pheochromocytoma in the adult and in the child. Am J Surg 99: 458–496, 1960.

    Article  PubMed  CAS  Google Scholar 

  11. Cuthberg JA, Gallagher ND, Turtle JR: Colonic and oesophageal disturbance in a patient with multiple endocrine neoplasia, type IIb. Aust N Z Med 8: 518–520, 1978.

    Article  Google Scholar 

  12. Posner JB: Neurological complications of systemic cancer. Med Clin North Am 63: 783–800, 1979.

    PubMed  CAS  Google Scholar 

  13. Veith RG, Odom GL: Extradural spinal metastases and their neurosurgical treatment. J Neurosurg 23: 501–508, 1965.

    Article  Google Scholar 

  14. Arseni CN, Simionescu MD, Horwath L: Tumors of the spine: A follow-up study of 350 patients with neurosurgical considerations. Acta Psychiatr Scand 34: 398–410, 1959.

    Article  PubMed  CAS  Google Scholar 

  15. Rodriguez M, Dinapoli RP: Spinal cord compression with special reference to metastatic epidural tumors. Mayo Clin Proc 55: 442–448, 1980.

    PubMed  CAS  Google Scholar 

  16. Petursson SR, Boggs DR: Spinal cord involvement in leukemia: A review of the literature and a case of Ph’ + acute myeloid leukemia presenting with a tonus medullaris syndrome. Cancer 47: 346–350, 1981.

    Article  PubMed  CAS  Google Scholar 

  17. Olsen CW: Leukemia as a cause of cauda equina syndrome. Bull Los Angeles Neurol Soc 1: 9598, 1935.

    Google Scholar 

  18. Gilbert RW, Kim JH, Posner JB: Epidural spinal cord compression from metastatic tumor: Diagnosis and treatment. Ann Neurol 3: 40–51, 1978.

    Article  PubMed  CAS  Google Scholar 

  19. Silvis RS, Riddle LR, Clark GG: Anterior sacral meningocele. Am Surg 22: 554–566, 1956.

    PubMed  CAS  Google Scholar 

  20. Anderson FM, Burke BL: Anterior sacral meningocele. J Am Med Assoc 237: 39–42, 1977.

    Article  CAS  Google Scholar 

  21. Fields AL, Josee RG, Bergsagel DE: Metabolic emergencies, in De Vita VT, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology. Toronto, JB Lippincott, 1982, pp 1594–1604.

    Google Scholar 

  22. Mundy GR, Martin TJ: Hypercalcemia of malignancy: Pathogenesis and treatment. Metabolism 31: 1247–1277, 1982.

    Article  PubMed  CAS  Google Scholar 

  23. Mundy GR, Raisz LG, Cooper RA, Schechter GP, Salmon SE: Evidence for the secretion of an osteoclast stimulating factor in myeloma. N Eng J Med 291: 1041–1046, 1974.

    Article  CAS  Google Scholar 

  24. Raisz LG, Simmons HA, Sandberg AL, Canalis E: Direct stimulation of bone resorption by epidermal growth factor. Endocrinology 107: 270–273, 1980.

    Article  PubMed  CAS  Google Scholar 

  25. Fillastre JP, Humbert G, Leroy J, et al: Furosemide, mithramycin and salmon calcitonin in hypercalcemia. Eur J Intensive Care Med 1: 185, 1975.

    Article  Google Scholar 

  26. Boyle IT, Foeglman I: Glucocorticoids and estrogens in the management of hypercalcemia. Met Bone Dis Rel Res 2: 203, 1980.

    Article  Google Scholar 

  27. Mannheimer IH: Hypercalcemia of breast cancer. Cancer 18: 679, 1965.

    Article  PubMed  CAS  Google Scholar 

  28. Slayton RE, Shnider BI, Elias E, et al: New approaches to the treatment of hypercalcemia: The effect of short-term treatment with mithramycin. Clin Pharmacol Ther 12: 833, 1971.

    PubMed  CAS  Google Scholar 

  29. Binstock ML, Mundy GR: Effect of calcitonin and glucocorticoids in combination on the hypercalcemia of malignancy. Ann Intern Med 93: 269, 1980.

    Article  PubMed  CAS  Google Scholar 

  30. Wisneski LA, Croom WP, Silva OK, et al: Salmon calcitonin in hypercalcemia. Clin Pharmacol Ther 24: 219, 1978.

    PubMed  CAS  Google Scholar 

  31. Jaffe JH, Martin WR: Opioid analgesics and antagonists, in Goodman-Gilman A, Goodman LS, Gilman A (eds): The Pharmacological Basis of Therapeutics, 6th ed. New York, Macmillan, 1980, pp 494–534.

    Google Scholar 

  32. Valdivieso M, Richman S, Burgess AM, Bodey DP, Freireich EJ: Initial clinical studies of vindesine. Cancer Treatment Rep 65: 873–875, 1981.

    CAS  Google Scholar 

  33. Neely J, Catchpole B: Ileus: The restoration of alimentary mobility by pharmacological means. Br J Surg 58: 21, 1971.

    Article  PubMed  CAS  Google Scholar 

  34. Binder MJ, Donowitz M: A new look at laxative action. Gastroenterology 69: 1001–1005, 1975.

    PubMed  CAS  Google Scholar 

  35. Pietruski RG: Use and abuse of laxatives. AM J Hosp Pharm 34: 291–300, 1977.

    Google Scholar 

  36. Stewart JY, Bass P: Effects of ricinoleic and oleic acids on the digestive contractile activity of the canine small and large bowel. Gastroenterology 70: 371–376, 1976.

    PubMed  CAS  Google Scholar 

  37. Garginella TS, Phillips SF: Ricinoleic acid (castor oil) alters intestinal surface structure. Mayo Clin Proc 51: 6–12, 1976.

    Google Scholar 

  38. Hardcastle JD, Wilkins JL: The action of semnosides and related compounds on human colon and rectum. Gut 11: 1038–1042, 1970.

    Article  PubMed  CAS  Google Scholar 

  39. Knowles JA: Effects on the infant of drug therapy in nursing mothers. Drug Ther 3: 57–65, 1973.

    CAS  Google Scholar 

  40. Sterr HW, Colin-Jones DG: Melanosis coli: Studies of the toxic effects of irritant purgatives. J Pathol 115: 199–205, 1975.

    Article  Google Scholar 

  41. Donovitz M: Current concepts of laxative action: Mechanisms by which laxatives increase stool water. Gastroenterology 1: 77–84, 1979.

    Google Scholar 

  42. Mordeo JP, Schwartz R, Arky RA: Extreme hypermagnesemia as a cause of refractory hypotension. Ann Intern Med 83: 657–658, 1975.

    Article  Google Scholar 

  43. Tedesco FJ, DiPiro JT: Laxative use in constipation. Am J Gastroenterol 80: 303–309, 1985.

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Oncology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York, 10467, USA

    Niculae Ciobanu M.D.

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  1. Niculae Ciobanu M.D.
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Editors and Affiliations

  1. Division of Medical Oncology, Department of Medicine, Albert Einstein College of Medicine, 10461, Bronx, New York, USA

    Janice P. Dutcher M.D. (Associate Professor of Medicine) (Associate Professor of Medicine)

  2. Department of Oncology, Montefiore Medical Center, 10461, Bronx, New York, USA

    Janice P. Dutcher M.D. (Associate Professor of Medicine) (Associate Professor of Medicine)

  3. Department of Oncology, Montefiore Medical Center, 10467, Bronx, New York, USA

    Peter H. Wiernik M.D. (Gutman Professor and Chairman, Director, Associate Director for Clinical Research) (Gutman Professor and Chairman, Director, Associate Director for Clinical Research)

  4. Division of Medical Oncology, Albert Einstein College of Medicine, 10467, Bronx, New York, USA

    Peter H. Wiernik M.D. (Gutman Professor and Chairman, Director, Associate Director for Clinical Research) (Gutman Professor and Chairman, Director, Associate Director for Clinical Research)

  5. Albert Einstein Cancer Center, 10467, Bronx, New York, USA

    Peter H. Wiernik M.D. (Gutman Professor and Chairman, Director, Associate Director for Clinical Research) (Gutman Professor and Chairman, Director, Associate Director for Clinical Research)

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© 1987 Springer Science+Business Media New York

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Ciobanu, N. (1987). Obstipation. In: Dutcher, J.P., Wiernik, P.H. (eds) Handbook of Hematologic and Oncologic Emergencies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0476-8_17

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  • DOI: https://doi.org/10.1007/978-1-4899-0476-8_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0478-2

  • Online ISBN: 978-1-4899-0476-8

  • eBook Packages: Springer Book Archive

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