Abstract
Over ten years ago, taurine was identified as an essential nutrient for cats (7). Without a dietary source of this amino acid, such as their natural taurine-rich diet of meat and fish, both kittens and adult cats undergo a decline in plasma and tissue taurine levels, reduced electroretinogram amplitudes with prolonged peak latencies, and progressive retinal degeneration which eventually results in blindness (8,24,26). As Dr. Sturman describes elsewhere in this volume, taurine deprivation of pregnant cats and their kittens also produces more widespread nervous system disturbances, including abnormal development of the cerebellum and visual cortex (19,27). Although cats appear to be unique in the severity of the effects produced by dietary taurine deprivation, it is now clear that they are not the only species affected. Recent studies of both human children and infant monkeys show that changes in retinal structure and function are associated with taurine deprivation.
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References
Abramov, I., Gordon, J., Hendrickson, A., Hainline, L., Dobson, V., and LaBossiere, E., 1982, The retina of the newborn human infant, Science, 217:265–266.
Barlow, H.B., 1975, Visual experience and cortical development, Nature, 258:199–124.
Blakemore, C., and Vital-Durand, F., 1981, Postnatal development of the monkey’s visual system, in: “The Fetus and Independent Life”, Ciba Foundation Symposium 86, Pitman, London, pp. 152–171.
Boothe, R.G., Dobson, V., and Teller, D.Y., 1985, Postnatal development of vision in human and nonhuman primates, Ann. Rev. Neurosci., 8:495–545.
Gaull, G.E., Rassin, D.K., Raiha, N.C.R., and Heinonen, K., 1977, Milk protein quantity and quality in low-birth-weight infants. III. Effects on sulfur amino acids in plasma and urine, J. Pediat., 90:348–355.
Geggel, H.S., Ament, M.E., Heckenlively, J.R., Martin, D.A., and Kopple, J.D., 1985, Nutritional requirement for taurine in patients receiving long-term parenteral nutrition, New Engl. J. Med., 312:142–146.
Hayes, K.C., Carey, S.Y., and Schmidt, S.Y., 1975, Retinal degeneration associated with taurine deficiency in the cat, Science, 188:949–951.
Hayes, K.C., Rabin, A.R., and Berson, E.L., 1975, An ultrastructural study of nutritionally induced and reversed retinal degeneration in cats, Am. J. Pathol., 78:505–516.
Hendrickson, A., and Kupfer, C., 1976, The histogenesis of the fovea in the macaque monkey, Invest. Ophthalmol., 15:746–756.
Hendrickson, A., and Yuodelis, C., 1984, The morphological development of the human fovea, Ophthalmology, 91:603–612.
Imaki, H., Moretz, R.C., Wisniewski, H.M., and Sturman, J.A., 1986, Feline maternal taurine deficiency: Effects on retina and tapetum of the offspring, Devel. Neurosci., 8:160–181.
Järvenpää, A.-L., Rassin, D.K., Räihä, N.C.R., and Gaull, G.E., 1982, Milk protein quantity and quality in the term infant. II. Effects on acidic and neutral amino acids, Pediatrics, 70:221–230.
Lake, N., and Cocker, S., 1986, The influence of lighting on the effects of taurine depletion in the rat retina, Invest. Ophthalmol. Vis. Sci., 27(Suppl. 3):57.
Lee, C, and Boothe, R.G., 1981, Visual acuity development in infant monkeys (Macaca nemestrina) having known gestational ages, Vision Res., 21:805–809.
Movshon, J.A., and Van Sluyters, R.C., 1981, Visual neural development, Ann. Rev. Psychol., 32:477–522.
Neuringer, M., Connor, W.E., Lin, D.S., Barstad, L. and Luck, S., 1986, Biochemical and functional effects of prenatal and postnatal omega-3 fatty acid deficiency on retina and brain in rhesus monkeys, Proc. Natl. Acad. Sci. USA, 83:4021–4025.
Neuringer, M., and Connor, W.E., 1986, Omega-3 fatty acids in. the retina and brain: Evidence for their essentiality, Nutr. Rev., 44:285–294.
Neuringer, M., Sturman, J.A., Wen, G.Y., and Wisniewski, H.M., 1985, Dietary taurine is necessary for normal retinal development in monkeys, in: “Taurine: Biological Actions and Clinical Perspectives”, S.S. Oja, L. Ahtee, P. Kontro and M.K. Paasonen, eds., Alan R. Liss, New York, pp. 53–62.
Palackal, T., Moretz, R., Wisniewski, H.M., and Sturman, J., 1986, Abnormal visual cortex development in the kitten associated with maternal dietary taurine deprivation, J. Neurosci. Res., 15:223–239.
Pasantes-Morales, H., Ademe, R.M., and Quesada, O., 1981, Protective effect of taurine on the light-induced disruption of isolated frog rod outer segments, J. Neurosci. Res., 6:337–348.
Pasantes-Morales, H., Dominguez, L., Campomanes, M.A., and Pacheco, P., 1986, Retinal degeneration induced by taurine deficiency in light-deprived cats, Exp. Eye Res., 43:55–60.
Rapp, L.M., Thum, L.A., Tarver, A.P., and Wiegand, R.D., 1986, Vitamin E and taurine deficiency: Effects on the retina in cyclic light-maintained and light-damaged rats, Invest. Ophthalmol. Vis. Sci., 27(Suppl.3):131.
Figo, J., and Senterre, J., 1977, Is taurine essential for the neonate?, Biol. Neonate, 32:73–76.
Schmidt, S.Y., Berson, E.L., and Hayes, K.C., 1976, Retinal degeneration in cats fed casein. I. Taurine deficiency, Invest. Ophthalmol., 15:45–52.
Schmidt, S.Y., Berson, E.L., and Hayes, K.C., 1976, Retinal degeneration in the taurine-deficient cat, Trans. Amer. Acad. Ophthalmol., 81:687–693.
Schmidt, S.Y., Berson, E.L., Watson, G., and Huang, G., 1977, Retinal degeneration in cats fed casein. III. Taurine deficiency and ERG amplitudes, Invest. Ophthalmol. Vis. Sci., 16:673–678.
Sturman, J.A., Moretz, R.C., French, J.H., and Wisniewski, H.M., 1985, Postnatal taurine deficiency in the kitten results in a persistence of the cerebellar external granule cell layer: Correction by taurine feeding, J. Neurosci. Res., 13:521–528.
Sturman, J.A., Wen, G.Y., Wisniewski, H.M., and Neuringer, M., 1984, Retinal degeneration in primates raised on a synthetic human infant formula, Int. J. Devel. Neurosci., 2:121–129.
Teller, D.Y., Morse, R., Borton, R., and Regal, D.M., 1974, Visual acuity for vertical and diagonal gratings in human infants, Vis. Res., 14:1433–1439.
Voaden, M.J., Hussain, A.A., and Lalji, K., 1984, Photochemical dam-age in the albino rat retina: Oral taurine has no effect on DNA and protein loss from severely damaged photoreceptor cells, J. Neurochem., 42:582–583.
Wiegand, R.D., Giusto, N.M., Rapp, L.M., and Anderson, R.E., 1983, Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina, Invest. Ophthalmol. Vis. Sci., 24:1433–1435.
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Neuringer, M., Imaki, H., Sturman, J.A., Moretz, R., Wisniewski, H.M. (1987). Abnormal Visual Acuity and Retinal Morphology in Rhesus Monkeys Fed a Taurine-Free Diet During the First Three Postnatal Months. In: Huxtable, R.J., Franconi, F., Giotti, A. (eds) The Biology of Taurine. Advances in Experimental Medicine and Biology, vol 217. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0405-8_12
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DOI: https://doi.org/10.1007/978-1-4899-0405-8_12
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