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Enteric Infections and Immunity pp 15–35Cite as

Mucosal Immunity

Molecular and Cellular Aspects of Immune Protection to Enteric Infections

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Part of the Infectious Agents and Pathogenesis book series (IAPA)

Abstract

Until recently, investigation into the mechanisms of mucosal immune protection has been overlooked as an integral component of immune surveillance. The failure to measure B- and T-cell responses in various mucosa-associated tissues and their secretions was complicated by difficulties in the isolation and characterization of mucosal lymphoid cells and in obtaining external secretions. The relevance of investigating mucosal immunity has been accentuated by recent developments, i.e., the failure of conventional vaccines to protect from mucosal pathogens when administered in parenteral sites and by the need for a mucosal vaccine to prevent the sexual transmission of HIV. In this review, we will discuss the nature of the gastrointestinal (GI) immune system and its subsequent manipulation, i.e., for vaccine development, to effect protection to enteric infectious agents. Furthermore, a better understanding of the GI immune system will contribute to the application of mucosal immunity for other tissues that are exposed to ubiquitous pathogens.

Keywords

  • Vasoactive Intestinal Peptide
  • Germinal Center
  • Vasoactive Intestinal Polypeptide
  • Oral Immunization
  • Inductive Site

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Author information

Authors and Affiliations

  1. Veterinary Molecular Biology, Montana State University, Bozeman, Montana, 59717-0360, USA

    David W. Pascual

  2. The Immunobiology Vaccine Center, Departments of Oral Biology and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, 35294-2170, USA

    Hiroshi Kiyono & Jerry R. McGhee

  3. Department of Mucosal Immunology, Research Institute for Microbial Disease, Osaka University, Osaka 565, Japan

    Hiroshi Kiyono & Jerry R. McGhee

Authors
  1. David W. Pascual
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  2. Hiroshi Kiyono
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  3. Jerry R. McGhee
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Editor information

Editors and Affiliations

  1. University of South Florida College of Medicine, Tampa, Florida, USA

    Lois J. Paradise & Herman Friedman & 

  2. University of Pisa, Pisa, Italy

    Mauro Bendinelli

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© 1996 Springer Science+Business Media New York

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Pascual, D.W., Kiyono, H., McGhee, J.R. (1996). Mucosal Immunity. In: Paradise, L.J., Bendinelli, M., Friedman, H. (eds) Enteric Infections and Immunity. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0313-6_2

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  • DOI: https://doi.org/10.1007/978-1-4899-0313-6_2

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