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Cancer Pain in the Elderly

  • Nathan I. Cherny
  • Beth Popp
Part of the The Springer Series in Adult Development and Aging book series (SSAD)

Abstract

Management of cancer pain in older patients presents a variety of challenges to the practicing physician, whether that physician is an oncologist, a gerontologist, or a physician who specializes the provision of primary care. The elderly experience more pain, both chronic and acute, than their younger counterparts (Closs, 1994). Furthermore, the balance between beneficial and adverse effects of pharmacotherapy and nondrug therapy is often more tenuous in the older patient, due to age-related physiological changes and the interaction between analgesics, concurrent illness, and pharmacotherapy for concurrent illness.

Keywords

Neuropathic Pain Cancer Pain Opioid Therapy Nonopioid Analgesic Morphine Sulphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abrams, P., & Fenely, R. (1976). The action of prostaglandins on smooth muscle of the human urinary tract in vitro. British Journal of Urology, 47, 909–915.CrossRefGoogle Scholar
  2. Agency for Health Care Policy and Research: Cancer Pain Management Panel. (1994). Management of cancer pain. Washington, DC, U.S. Department of Health and Human Services.Google Scholar
  3. Alexander, A. M., Veitch, G. B., & Wood, J. B. (1985). Anti-rheumatic and analgesic drug usage and acute gastro-intestinal bleeding in elderly patients. Journal of Clinical Hospital Pharmacology, 10(1), 89–93.Google Scholar
  4. American College of Physicians Health and Public Policy Committee (1983). Drug therapy for severe chronic pain in terminal illness. Annals of Internal Medicine, 99, 870–880.CrossRefGoogle Scholar
  5. American Pain Society. (1992). Principles of analgesic use in the treatment of acute pain and chronic cancer pain. A concise guide to medical practice (3rd ed.). Skokie, IL: American Pain Society.Google Scholar
  6. American Psychiatric Association. (1987). Somatoform disorders. In Diagnostic and statistical manual of mental disorders (pp. 255–267). Washington, DC: American Psychiatric Association.Google Scholar
  7. Amesbury, B. D. W. (1989). Use of SC midazolam in the home care setting. Palliative Medicine, 3, 299–301.CrossRefGoogle Scholar
  8. Arbit, E. (1990). Neurosurgical management of cancer pain. In K. M. Foley, J. J. Bonica, & V. Ventafridda (Eds.), Second International Congress on Cancer Pain (pp. 289–300). New York: Raven Press.Google Scholar
  9. Arkinstall, W. W., Goughnour, B. R., White, J. A., & Stewart, J. H. (1989). Control of severe pain with sustained-release morphine tablets v. oral morphine solution. Canadian Medical Association Journal, 140(6), 653–657.PubMedGoogle Scholar
  10. Arner, S., & Meyerson, B. A. (1988). Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain, 33(1), 11–23.PubMedCrossRefGoogle Scholar
  11. Baines, M. (1993). The pathophysiology and management of malignant intestinal obstruction. In D. Doyle, G. W. Hanks, & N. MacDonald (Eds.), Oxford textbook of palliative medicine (pp. 311–316). Oxford: Oxford University Press.Google Scholar
  12. Baines, M. J. (1990). Management of malignant intestinal obstruction in patients with advanced cancer. In K. M. Foley, J. J. Bonica, & V. Ventafridda (Eds.), Second International Congress on Cancer Pain (pp. 327–336). New York: Raven Press.Google Scholar
  13. Ballinger, A. (1994). Cytoprotection with misoprostol: Use in the treatment and prevention of ulcers. Digestive Diseases, 72(1), 37–45.CrossRefGoogle Scholar
  14. Banning, A., Sjogren, P., & Henriksen, H. (1991). Pain causes in 200 patients referred to a multidisciplinary cancer pain clinic. Pain, 45(1), 45–48.PubMedCrossRefGoogle Scholar
  15. Bayouth, J. E., Macey, D. J., Kasi, L. P., & Fossella, F. V. (1994). Dosimetry and toxicity of samarium-153-EDTMP administered for bone pain due to skeletal metastases. Journal of Nuclear Medicine, 35(1), 63–69.PubMedGoogle Scholar
  16. Beaver, W. T., & Feise, G. (1977). Comparison of the analgesic effect oxymorphone by rectal suppository and intramuscular injection in patients with postoperative pain. Journal of Clinical Pharmacology, 17, 276.PubMedCrossRefGoogle Scholar
  17. Bender, A. D. (1965). The effect of increased age on the distribution of pheripheral blood flow in man. Journal of the American Geriatric Society, 13, 192–196.Google Scholar
  18. Bonica, J. J., Buckley, F. P., Moricca, G., & Murphey, T. M. (1990a). Neurolytic blockade and hypohysectomy. In J. J. Bonica (Ed.), The management of pain (pp. 1980–2039). Philadelphia: Lea & Febiger.Google Scholar
  19. Bonica, J. J., Ventafridda, V, & Twycross, R. G. (1990b). Cancer pain. In J. J. Bonica (Ed.), The management of pain (pp. 400–460). Philadelphia: Lea & Febiger.Google Scholar
  20. Boquet, J., Moore, N., Lhuintre, J. P., & Boismare, F. (1986). Diltiazem for proctalgia fugax [letter]. The Lancet, 1 (8496), 1493.CrossRefGoogle Scholar
  21. Bradberry, J. C., & Reabel, M. A. (1981). Continuous infusion of naloxone in the treatment of narcotic overdose. Drug Intelligence and Clinical Pharmacy, 15, 85–90.Google Scholar
  22. Bradley, D. V, & Cazort, R. J. (1970). Relief of bladder spasm by flavoxate. A comparative study. Journal of Clinical Pharmacology, 10(1), 65–68.Google Scholar
  23. Brennan, M. J. (1992). Management of lymphedema: review of pathophysiology and treatment. Journal of Pain and Symptom Management, 7, 110–116.PubMedCrossRefGoogle Scholar
  24. Brescia, F. J., Adler, D., Gray, G., Ryan, M. A., Climino, J., & Mamtani, R. (1990). Hospitalized advanced cancer patients: a profile. Journal of Pain Symptom Management, 5(4), 221–227.PubMedCrossRefGoogle Scholar
  25. Brescia, F. J., Portenoy, R. K., Ryan, M., Krasnoff, L., & Gray, G. (1992). Pain, opioid use, and survival in hospitalized patients with advanced cancer. Journal of Clinical Oncology, 10(1), 149–155.PubMedGoogle Scholar
  26. Brooks, P. M, & Wood, A. J. J. (1991). Nonsteroidal antiinflammatory drugs-differences and similarities. New England Journal of Medicine, 324, 1716–1725.PubMedCrossRefGoogle Scholar
  27. Brown, D. L., Bulley, C. K., & Quiel, E. C. (1987). Neurolytic celiac plexus blockade for pancreatic cancer pain. Anesthesia and Analgesia, 66, 869–873.PubMedGoogle Scholar
  28. Bruera, E., Brenneis, G., Michaud, M., Bacovsky, R., Chadwick, S., Emeno, A., & MacDonald, N. (1988a). Use of the subcutaneous route for the administration of narcotics in patients with cancer pain. Cancer, 62(2), 407–411.PubMedCrossRefGoogle Scholar
  29. Bruera, E., Brenneis, G., Michaud, M., MacMillan, K., Hanson, J., & MacDonald, R. N. (1988b). Patient-controlled subcutaneous hydromorphone versus continuous subcutaneous infusion for the treatment of cancer pain. Journal of the National Cancer Institute, 80(14), 1152–1154.PubMedCrossRefGoogle Scholar
  30. Bruera, E., Fainsinger, R., Moore, M., Thibault, R., Spoldi, E., & Ventafridda, V. (1991). Local toxicity with subcutaneous methadone: Experience of two centers. Pain, 45, 141–145.PubMedCrossRefGoogle Scholar
  31. Bruera, E., Macmillan, K., Hanson, J., & MacDonald, R. N. (1989). The cognitive effects of the administration of narcotic analgesics in patients with cancer pain. Pain, 39(1), 13–16.PubMedCrossRefGoogle Scholar
  32. Bruera, E., Macmillan, K., Selmser, P., & MacDonald, R. N. (1990). Decreased local toxicity with subcutaneous diamorphine (heroin): A preliminary report. Pain, 43(1), 91–94.PubMedCrossRefGoogle Scholar
  33. Bruera, E., Roca, E., Cedaro, L., Carraro, S., & Chacon, R. (1985). Action of oral methylprednisolone in terminal cancer patients: A prospective randomized double-blind study. Cancer Treatment Report, 69, 751–754.Google Scholar
  34. Burke, A. L., Diamond, P. L., Hulbert, J., Yeatman, J., & Farr, E. A. (1991). Terminal restlessness—Its management and the role of midazolam. Medical Journal of Australia, 155(7), 485–487.PubMedGoogle Scholar
  35. Campora, E., Merlini, L., Pace, M., Bruzzone, M., Luzzani, M., Gottleib, A., & Rosso, R. (1991). The incidence of narcotic induced emesis. Journal of Pain and Symptom Management, 6(7), 428–430.PubMedCrossRefGoogle Scholar
  36. Canobbio, L., Boccardo, F., Cannata, D., Gallotti, P., & Epis, R. (1992). Treatment of advanced pancreatic carcinoma with the somatostatin analogue BIM 23014: Preliminary results of a pilot study. Cancer, 69(3), 648–650.PubMedCrossRefGoogle Scholar
  37. Cardozo, L. D., & Stanton, S. L. (1981). A comparison between bromocriptine and indomethacin in the treatment of detrusor instability. Journal of Urology, 73, 236–239.Google Scholar
  38. Carnel, S. B., Blakeslee, D. B., Oswald, S. G., & Barnes, M. (1990). Treatment of radiation-and chemotherapy-induced stomatitis. Otolaryngology—Head and Neck Surgery, 102(4), 326–330.PubMedGoogle Scholar
  39. Castell, D. O. (1986). Calcium blocking agents for gastrointestinal disorders. American Journal of Cardiology, 55, 210B–215B.CrossRefGoogle Scholar
  40. Chan, G. L., & Matzke, G. R. (1987). Effects of renal insufficiency on the pharmacokinetics and pharmaco-dynamics of opioid analgesics. Drug Intelligence and Clinical Pharmacology, 21(10), 773–783.Google Scholar
  41. Chapman, C. R., & Hill, H. F. (1989). Prolonged morphine self-administration and addiction liability. Cancer, 63, 1636–1644.PubMedCrossRefGoogle Scholar
  42. Cherny, N. I., & Portenoy, R. K. (1994). Sedation in the treatment of refractory symptoms: guidelines for evaluation and treatment. Journal of Palliative Care, 10(2), 31–38.PubMedGoogle Scholar
  43. Cherny, N. I., Thaler, H. T., Friedlander-Klar, H., Lapin, J., Foley, K. M., Houde, R., & Portenoy, R. K. (1994). Opioid responsiveness of cancer pain syndromes caused by neuropathic or nociceptive mechanisms: A combined analysis of controlled single dose studies. Neurology, 44, 857–861.PubMedCrossRefGoogle Scholar
  44. Cherny, N. I., Thaler, H. T., Friedlander-Klar, H., Lapin, J., & Portenoy, R. K. (1992). Opioid responsiveness of neuropathic cancer pain: Combined analysis of single-dose analgesic trials. Proceedings of the American Society of Clinical Oncology, 11, 1330.Google Scholar
  45. Citron, M., Conaway, M., Zhukovsky, D., Kornblith, A. B., Berkowitz, I., Pascall, V., Smith, W., & Vinciguerra, V. (1993). Efficacy of patient-controlled analgesia (PCA) vs continuous iv morphine (CIVM) for the treatment of severe cancer pain: CALGB 8872 (meeting abstract). Proceedings of the Annual Meeting of the American Society of Clinical Oncologists.Google Scholar
  46. Cleeland, C. (1991). Research in cancer pain: What we know and what we need to know. Cancer, 3(1), 823–827.CrossRefGoogle Scholar
  47. Cleeland, C. S. (1984). The impact of pain on the patient with cancer. Cancer, 54, 2635–2641.PubMedCrossRefGoogle Scholar
  48. Cleeland, C. S. (1988). Clinical cancer: 31. Barriers to the management of cancer pain: the roles of patient and family. Wisconsin Medical Journal, 87(11), 13–15.PubMedGoogle Scholar
  49. Cleeland, C. S. (1989). Pain control: public and physician’s attitudes. In C. S. Hill & W. S. Fields (Eds.), Drug treatment of cancer pain in a drug-oriented society (pp. 81–89). New York: Raven Press.Google Scholar
  50. Cleeland, C. S., Cleeland, L. M., Dar, R., & Rinehardt, L. C. (1986). Factors influencing physician management of cancer pain. Cancer, 58(3), 796–800.PubMedCrossRefGoogle Scholar
  51. Clemens, M. R., Fessele, K., & Heim, M. E. (1993). Multiple myeloma: effect of daily dichloromethylene bisphosphonate on skeletal complications. Annals of Hematology, 66(3), 141–146.PubMedCrossRefGoogle Scholar
  52. Closs, S. J. (1994). Pain in elderly patients: A neglected phenomenon? Journal of Advanced Nursing, 19(6), 1072–1081.PubMedCrossRefGoogle Scholar
  53. Clouston, P., De Angelis, L., & Posner, J. B. (1992). The spectrum of neurologic disease in patients with systemic cancer. Annals of Neurology, 31, 268–273.PubMedCrossRefGoogle Scholar
  54. Coleman, R. E., Woll, P. J., Miles, M., Scrivener, W., & Rubens, R. D. (1988). Treatment of bone metastases with (3 amino-1-hydroxyprpylidene)-1, 1-bisphosphonate (APD). British Journal of Cancer, 58, 621–625.PubMedCrossRefGoogle Scholar
  55. Cooper, C. M., Gerrish, S. P., Hardwick, M., & Kay, R. (1987). EMLA cream reduces the pain of venipuncture in children. European Journal of Anaesthesiology, 4(6), 441–448.PubMedGoogle Scholar
  56. Cousins, M. J., Dwyer, B., & Gibb, D. (1988). Chronic pain and neurolytic blockade. In M. J. Cousins & P. O. Bridenbaugh (Eds.), Neural blockade in clinical anesthesia and management of pain (pp. 1053–1084). Philadelphia: Lippincott.Google Scholar
  57. Coyle, N., Adelhardt, J., & Foley, K. M. (1988). Disease progression and tolerance in the cancer pain patient. 2nd International Congress on Cancer Pain. Journal of Pain and Symptom Management, 3, S25.CrossRefGoogle Scholar
  58. Coyle, N., Adelhardt, J., Foley, K. M., & Portenoy, R. K. (1990). Character of terminal illness in the advanced cancer patient: Pain and other symptoms during last four weeks of life. Journal of Pain and Symptom Management, 5, 83–89.PubMedCrossRefGoogle Scholar
  59. Coyle, N., Breitbart, W., Weaver, S., & Portenoy, R. K. (1994a). Delerium as a contributing factor to “crecendo” pain: Three case reports. Journal of Pain and Symptom Management, 9(1), 44–47.PubMedCrossRefGoogle Scholar
  60. Coyle, N., Cherny, N. I., & Portenoy, R. K. (1994b). Subcutaneous opioid infusions in the home. Oncology, 8(4), 21–27.PubMedGoogle Scholar
  61. Coyle, N., Mauskop, A., & Maggard, J. (1986). Continuous subcutaneous infusions of opiates in cancer patients with pain. Oncology Nursing Forum, 13, 53–57.PubMedGoogle Scholar
  62. Crammond, T., & Stuart, G. (1993). Intraventricular morphine for intractable pain of advanced cancer. Journal of Pain and Symptom Management, 8(7), 465–473.CrossRefGoogle Scholar
  63. Crawford, J., & Cohen, H. J. (1987). Relationship of cancer and aging. Clinical Geriatric Medicine, 3(3), 419–432.Google Scholar
  64. Crews, J. C., Sweeney, N. J., & Denson, D. D. (1993). Clinical efficacy of methadone in patients refractory to other mu-opioid receptor agonist analgesics for management of terminal cancer pain: Case presentations and discussion of incomplete cross-tolerance among opioid agonist analgesics. Cancer, 72(7), 2266–2272.PubMedCrossRefGoogle Scholar
  65. Culpepper-Morgan, J. A., Inturrisi, C. E., Portenoy, R. K., Foley, K. M., Houde, R. W., Marsh, F., & Kreek, M. J. (1992). Treatment of opioid induced constipation with oral naloxone: A pilot study. Clinical Pharmacology and Therapeutics, 52, 90–95.PubMedCrossRefGoogle Scholar
  66. Daut, R. L., & Cleeland, C. S. (1982). The prevalence and severity of pain in cancer. Cancer, 50, 1913–1918.PubMedCrossRefGoogle Scholar
  67. Daykin, A. P., Bowen, D. J., Saunders, D. A., & Norman, J. (1986). Respiratory depression after morphine in the elderly: A comparison with younger subjects. Anaesthesia, 41(9), 910–914.PubMedCrossRefGoogle Scholar
  68. Dearnaley, D. P., Bayly, R. J., A’Hern, R. P., Gadd, J., Zivanovic, M. M, & Lewington, V. J. (1992). Palliation of bone metastases in prostate cancer. Hemibody irradiation or strontium-89? Clinical Oncology (Royal College of Radiologists), 4(2), 101–107.CrossRefGoogle Scholar
  69. De Conno, F., Carraceni, A., Zecca, E., Spoldi, E., & Ventafridda, V. (1991). The continuous subcutaneous infusion of hyoscine butyl bromide reduces secretions in patients with gastrointestinal obstruction. Journal of Pain and Symptom Management, 6, 484–486.PubMedCrossRefGoogle Scholar
  70. De Conno, F., Ripamonti, C., Sbanotto, A., & Barletta, L. (1993). A clinical note on sublingual buprenorphine. Journal of Palliative Care, 9(3), 44–46.PubMedGoogle Scholar
  71. Delia Cuna, G. R., Pellegrini, A., & Piazzi, M. (1989). Effect of methylprednisolone sodium succinate on quality of life in preterminal cancer patients: A placebo-control multicenter study. European Journal of Cancer and Clinical Oncology, 29, 1817–1821.Google Scholar
  72. Dennis, G. C., & DeWitty, R. L. (1990). Long-term intraventricular infusion of morphine for intractable pain in cancer of the head and neck. Neurosurgery, 26, 404–407.PubMedCrossRefGoogle Scholar
  73. de Stoutz, N. D., Bruera, E., & Suarez-Almazor, M. (1993). Opiate rotation (OR) for toxicity reduction in terminal cancer patients. In 7th World Congress on Pain: Congress Abstracts (abstract 894). Seattle: IASP Publications.Google Scholar
  74. Devor, M., Basbaum, A. I., Bennett, G. J., Blumberg, H., Campbell, J. N., Dembowsky, K. P., Guillbaud, G., Janig, W., Koltzberg, M., Levine, J. D., Otten, U. H., & Portenoy, R. K. (1991). Group report: Mechanisms of neuropathic pain following peripheral injury. In A. Basbaum & J.-M. Besson (Eds.), Towards a new pharmacotherapy of pain (pp. 417–440). New York: Wiley.Google Scholar
  75. Dover, S. B. (1987). Syringe driver in terminal care. British Medical Journal, 294, 553–555.PubMedCrossRefGoogle Scholar
  76. Dubner, R. (1991). A call for more science, not more rhetoric, regarding opioids and neuropathic pain. Pain, 47(1), 1–2.PubMedCrossRefGoogle Scholar
  77. Du Pen, S. L., & Ramsey, D. H. (1988). Compounding local anaesthetics and narcotics for epidural analgesia in cancer out patients. Anaesthesiology, 69(3A), A404.Google Scholar
  78. Edwards, R. B. (1989). Pain management and the values of health care providers. In C. S. Hill & W. S. Fields (Eds.), Drug treatment of cancer pain in a drug oriented society (pp. 101–112). New York: Raven Press.Google Scholar
  79. Edwards, W. T., & Breed, R. J. (1990). Treatment of postoperative pain in the post anesthesia care unit. Anesthesiology Clinics of North America, 8, 235–265.Google Scholar
  80. Egbert, A. M., Parks, L. H., Short, L. M., & Burnett, M. L. (1990). Randomized trial of postoperative patient-controlled analgesia vs intramuscular narcotics in frail elderly men. Archives of Internal Medicine, 150(9), 1897–1903.PubMedCrossRefGoogle Scholar
  81. Eisele, J. H., Grigsby, E. J., & Dea, G. (1992). Clonazepam treatment of myoclonic contractions associated with high dose opioids: a case report. Pain, 49(2), 231–232.PubMedCrossRefGoogle Scholar
  82. Eisenberg, E., Berkey, C. S., Carr, D. B., Mosteller, F., & Chalmers, T. C. (1994). Efficacy and safety of nonsteroidal antiinflammatory drugs for cancer pain: a meta-analysis. Journal of Clinical Oncology, 12(12), 2756–2765.PubMedGoogle Scholar
  83. Eisendrath, S. J., Goldman, B., Douglas, J., Dimatteo, L., & Van, D. C. (1987). Meperidine-induced delirium. American Journal of Psychiatry, 144(8), 1062–1065.PubMedGoogle Scholar
  84. Enck, R. E. (1991). Drug-induced terminal sedation for symptom control. American Journal of Hospice and Palliative Care, 8(5), 3–5.CrossRefGoogle Scholar
  85. Ernst, D. S., MacDonald, R. N., Paterson, A. H. G., Jensen, J., Brasher, P., & Bruera, E. (1992). A double blind, crossover trial of I.V. clodronate in metastatic bone pain. Journal of Pain and Symptom Management, 7, 4–11.PubMedCrossRefGoogle Scholar
  86. Ettinger, A. B., & Portenoy, R. K. (1988). The use of corticosteroids in the treatment of symptoms associated with cancer. Journal of Pain and Symptom Management, 3, 99–103.PubMedCrossRefGoogle Scholar
  87. Fainsinger, R., Schoeller, T., & Bruera, E. (1993). Methadone in the management of cancer pain: A review. Pain, 52(2), 137–147.PubMedCrossRefGoogle Scholar
  88. Ferrell, B. A., & Ferrell, B. R. (1991). Principles of pain management in older people. Comprehensive Therapy, 17(8), 53–58.PubMedGoogle Scholar
  89. Ferrell, B. R., Ferrell, B. A., Ahn, C., & Tran, K. (1994). Pain management for elderly patients with cancer at home. Cancer, 74(suppl.), 2139–2146.PubMedCrossRefGoogle Scholar
  90. Fineman, S. P. (1989). Long-term post-thoracotomy cancer pain management with interpleural bupivacaine. Anesthesia and Analgesia, 68(5), 694–697.PubMedCrossRefGoogle Scholar
  91. Fishman, B., Pasternak, S., Wallenstein, S. L., Houde, R. W., Holland, J. C., & Foley, K. M. (1987). The Memorial Pain Assessment Card: A valid instrument for the evaluation of cancer pain. Cancer, 60, 1151–1158.PubMedCrossRefGoogle Scholar
  92. Foley, K. M. (1982). Clinical assessment of pain. Acta Anaesthica Scandinavica, 74(suppl.), 91–96.CrossRefGoogle Scholar
  93. Foley, K. M. (1985). The treatment of cancer pain. New England Journal of Medicine, 313, 84–95.PubMedCrossRefGoogle Scholar
  94. Foley, K. M. (1989a). Controversies in cancer pain: Medical perspective. Cancer, 63, 2257–2265.PubMedCrossRefGoogle Scholar
  95. Foley, K. M. (1989b). The decriminalization of cancer pain. In C. S. Hill & H. Field (Eds.), Drug treatment of cancer pain in a drug-oriented society (pp. 5–18). New York: Raven Press.Google Scholar
  96. Foley, K. M. (1991). Clinical tolerance to opioids. In A. I. Basbaum & J. M. Bessom (Eds.), Towards a new pharmacotherapy of pain, Dahlem Konfrenzen (pp. 181–204). Chichester: Wiley.Google Scholar
  97. Fossa, S. D., Paus, E., Lochoff, M., Backe, S. M., & Aas, M. (1992). Strontium-89 in bone metastases from hormone resistant prostate cancer: Palliation effect and biochemical changes. British Journal of Cancer, 66(1), 177–180.PubMedCrossRefGoogle Scholar
  98. Galer, B. S., Coyle, N., Pasternak, G. W., & Portenoy, R. K. (1992). Individual variability in the response to different opioids: Report of five cases. Pain, 49(1), 87–91.PubMedCrossRefGoogle Scholar
  99. Geokas, M. C., & Haverbck, B. J. (1969). The aging gastrointestinal tact. American Journal of Surgery, 117, 881–887.PubMedCrossRefGoogle Scholar
  100. Goldberg, P. B., & Roberts, J. (1983). Pharmacologic basis for developing rational drug regimens for elderly patients. Medical Clinics of North America, 67, 315.PubMedGoogle Scholar
  101. Goldfrank, L., Weisman, R. S., Enick, J. K., & Lo, M. W. (1986). A dosing nomogram for continuous infusion of intravenous naloxone. Annals of Emergency Medicine, 15(5), 91–95.CrossRefGoogle Scholar
  102. Gonzales, G. R., Elliot, K. J., Portenoy, R. K., & Foley, K. M. (1991). The impact of a comprehensive evaluation in the management of cancer pain. Pain, 47, 141–144.PubMedCrossRefGoogle Scholar
  103. Gourlay, G. K., Kowalski, S. R., Plummer, J. L., Cherry, D. A., Szekely, S. M., Mather, L. E., Owen, H., & Cousins, M. J. (1990). The efficacy of transdermal fentanyl in the treatment of postoperative pain; a double blind comparison of fentanyl and placebo systems. Pain, 40, 21–28.PubMedCrossRefGoogle Scholar
  104. Greene, W. R., & Davis, W. H. (1991). Titrated intravenous barbiturates in the control of symptoms in patients with terminal cancer, Southern Medical Journal, 84(3), 332–337.PubMedCrossRefGoogle Scholar
  105. Grossman, S. A., Sheidler, V. R., Swedeen, K., Mucenski, J., & Piantadosi, S. (1991). Correlation of patient and caregiver ratings of cancer pain. Journal of Pain and Symptom Management, 6(2), 53–57.PubMedCrossRefGoogle Scholar
  106. Hagen, N., Foley, K. M., Cerbones, D. J., Portenoy, R. K., & Inturrisi, C. E. (1991). Chronic nausea and morphine-6-glucuronide. Journal of Pain and Symptom Management, 6, 125–128.PubMedCrossRefGoogle Scholar
  107. Hagmeyer, K. O., Mauro, L. S., & Mauro, V. F. (1993). Meperidine-related seizures associated with patient-controlled analgesia pumps. Annals of Pharmacotherapy, 27(1), 29–32.PubMedGoogle Scholar
  108. Haines, I. E., Zalcberg, J., & Buchanan, J. D. (1990). Not-for-recussitation orders in cancer patients: Principles of decision making. Medical Journal of Australia, 153(7), 225–229.PubMedGoogle Scholar
  109. Halperin, D. L., Koren, G., Attias, D., Pellegrini, E., Greenberg, M. L., & Wyss, M. (1989). Topical skin anesthesia for venous, subcutaneous drug reservoir and lumbar punctures in children. Pediatrics, 84(2), 281–284.PubMedGoogle Scholar
  110. Hanks, G. W. (1984). Psycchotropic drugs. Clinics in Oncology, 3, 135–151.Google Scholar
  111. Hanks, G. W., Twycross, R. G., & Lloyd, J. W. (1981). Unexpected complication of successful nerve block: Morphine induced respiratory depression precipitated by removal of severe pain. Anaesthesia, 36(1), 37–39.PubMedCrossRefGoogle Scholar
  112. Hanks, G. W. C., Portenoy, R. K., MacDonald, N., & O’Niel, W. M. (1993). Difficult pain problems. In D. Doyle, G. W. Hanks, & N. MacDonald (Eds.), Oxford textbook of palliative medicine (pp. 257–274). Oxford: Oxford University Press.Google Scholar
  113. Hanning, C. D. (1990). The rectal absorption of opioids. In C. Benedetti, C. R. Chapman, & G. Giron (Eds.), Opioid Analgesia (pp. 259–269). New York: Raven Press.Google Scholar
  114. Hassenbusch, S. J., Pillay, P. K., & Barnett, G. M. (1990). Radiofrequency cingulotomy for intractable cancer pain using stereotaxis guided by magnetic resonance imaging. Neurosurgery, 27(2), 220–223.PubMedCrossRefGoogle Scholar
  115. Hays, H., Hagen, N., Thirlwell, M., Dhaliwal, H., Babul, N., Harsanyi, Z., & Darke, A. C. (1994). Comparative clinical efficacy and safety of immediate release and controlled release hydromorphone for chronic severe cancer pain. Cancer, 74(6), 1808–1816.PubMedCrossRefGoogle Scholar
  116. Hellendoorn, S. M., & Overweg van Kints, J. (1988). Perineal pain: A case report. European Journal of Surgical Oncology, 14(2), 197–198.Google Scholar
  117. Helmers, H., Van Peer, A., Woestenborghs, R., Noorduin, H., & Heykants, J. (1984). Alfentanil kinetics in the elderly. Clinical Pharmacology and Therapeutics, 36(2), 239–243.PubMedCrossRefGoogle Scholar
  118. Helmers, J. H., van Leeuwen, L., & Zuurmond, W. W. (1994). Sufentanil pharmacokinetics in young adult and elderly surgical patients. European Journal of Anaesthesiology, 11(3), 181–185.PubMedGoogle Scholar
  119. Herr, K. A., & Mobily, P. R. (1993). Comparison of selected pain assessment tools for use with the elderly. Applied Nursing Research, 6(1), 39–46.PubMedCrossRefGoogle Scholar
  120. Hogan, Q., Haddox, J. D., Abram, S., Weissman, D., Taylor, M. L., & Janjan, N. (1991). Epidural opiates and local anesthetics for the management of cancer pain. Pain, 46(3), 271–279.PubMedCrossRefGoogle Scholar
  121. Holdsworth, M. T., Forman, W. B., Killilea, T. A., Nystrom, K. M., Paul, R., Brand, S. C., & Reynolds, R. (1994). Transdermal fentanyl disposition in elderly subjects. Gerontology, 40(1), 32–37.PubMedCrossRefGoogle Scholar
  122. Holley, F. O., & Van Steennis, C. (1988). Postoperative analgesia with fentanyl: pharmacokinetics and pharmacodynamics of constant-rate I.V. and transdermal delivery. British Journal of Anaesthesia, 60, 608–613.PubMedCrossRefGoogle Scholar
  123. Houde, R. W. (1979). Analgesic effectiveness of narcotic agonist-antagonists. British Journal of Clinical Pharmacology, 7, 297–308.CrossRefGoogle Scholar
  124. Ihse, I., & Permerth, J. (1990). Enzyme therapy and pancreatic pain. Acta Churgica Scandinavica, 156, 281–283.Google Scholar
  125. Insel, P. A. (1990). Analgesic-antipyretics and antiinflammatory agents: drugs employed in the treatment of rheumatoid arthritis and gout. In A. G. Gilman, T. W. Rall, A. S. Nies, & P. Teylor (Eds.), The pharmacological basis of therapeutics (pp. 638–681). New York: Permagon Press.Google Scholar
  126. Ischia, S., Luzzani, A., Ischia, A., Magon, F., & Toscano, D. (1984). Subarachnoid neurolytic block (L5-S1) and unilateral percutaneous cervical cordotomy in the treatment of pain secondary to pelvic malignant disease. Pain, 20(2), 139–149.PubMedCrossRefGoogle Scholar
  127. Jadad, A. R., Carroll, D., Glynn, C. J., Moore, R. A., & McQuay, H. J. (1992). Morphine responsiveness of chronic pain: double blind randomised crossover study with patient controlled analgesia. The Lancet, 339, 1367–1371.CrossRefGoogle Scholar
  128. Jaillon, P., Gardin, M. E., Lecocq, B., Richard, M. O., Meignan, S., Blondel, Y., Grippat, J. C., Bergnieres, J., & Vergnoux, O. (1989). Pharmacokinetics of nalbuphine in infants, young healthy volunteers, and elderly patients. Clinical Pharmacology and Therapeutics, 46(2), 226–233.PubMedCrossRefGoogle Scholar
  129. Janig, W., Blumberg, H., Boas, R. A., & Campbell, J. N. (1991). The reflex sympathetic dystrophy syndrome: Consensus statement and general recommendations for diagnosis and clinical research. In M. R. Bond, J. E. Charlton, & C. J. Woolf (Eds.), Proceedings of the VIth World Congress on Pain (pp. 373–382). Amsterdam: Elsevier.Google Scholar
  130. Kaiko, R. F. (1980). Age and morphine analgesia in cancer patients with postoperative pain. Clinical Pharmacology and Therapeutics, 28, 823–826.PubMedCrossRefGoogle Scholar
  131. Kaiko, R. F., Foley, K. M., Grabinski, P. V., Heidrich, G., Rogers, A. G., Inturrisi, C. E., & Reidenberg, M. M. (1983). Central nervous system excitatory effects of meperidine in cancer patients. Annals of Neurology, 13, 180–185.PubMedCrossRefGoogle Scholar
  132. Kanner, R. M., & Foley, K. M. (1981). Patterns of narcotic drug use in a cancer pain clinic. Annals of the New York Academy of Science, 362, 161–172.CrossRefGoogle Scholar
  133. Kapelushnik, J., Koren, G., Solh, H., Greenberg, M., & De Veber, L. (1990). Evaluating the efficacy of EMLA in alleviating pain associated with lumbar puncture; comparison of open and double-blinded protocols in children. Pain, 42(1), 31–34.PubMedCrossRefGoogle Scholar
  134. Kellgren, J. G. (1939). On distribution of pain arising from deep somatic structures with charts of segmental pain areas. Clinical Science, 4, 35–46.Google Scholar
  135. Laing, A. H., Ackery, D. M., Bayly, R. J., Buchanan, R. B., Lewington, V. J., McEwan, A. J., Macleod, P. M., & Zivanovic, M. A. (1991). Strontium-89 chloride for pain palliation in prostatic skeletal malignancy. British Journal of Radiology, 64(765), 816–822.PubMedCrossRefGoogle Scholar
  136. Latimer, E. J. (1991). Ethical decision-making in the care of the dying and its applications to clinical practice. Journal of Pain and Symptom Management, 6, 329–336.PubMedCrossRefGoogle Scholar
  137. Leavens, E. S., Hill, C. S., Cech, D. A., Weyland, J. B., & Weston, J. S. (1982). Intrathecal and intraventricular morphine for pain in cancer patients. Journal of Neurosurgery, 56, 241–245.PubMedCrossRefGoogle Scholar
  138. Lee, T. L., Kumar, A., & Baratham, G. (1990). Intraventricular morphine for intractable craniofacial pain. Singapore Medical Journal, 31(3), 273–276.PubMedGoogle Scholar
  139. Lema, M. J., Myers, D. P., De, L. C. O., & Penetrante, R. (1992). Pleural phenol therapy for the treatment of chronic esophageal cancer pain. Regional Anesthesia, 17(3), 166–170.PubMedGoogle Scholar
  140. Levin, A. B., & Ramirez, L. L. (1984). Treatment of cancer pain with hypophysectomy: Surgical and chemical. In C. Benedetti, C. R. Chapman, & G. Moricca (Eds.), Recent advances in the management of pain (pp. 631–645). New York: Raven Press.Google Scholar
  141. Lewington, V. J., McEwan, A. J., Ackery, D. M., Bayly, R. J., Keeling, D. H., Macleod, P. M., Porter, A. T, & Zivanovic, M. A. (1991). A prospective, randomised double-blind crossover study to examine the efficacy of strontium-89 in pain palliation in patients with advanced prostate cancer metastatic to bone. European Journal of Cancer, 27(8), 954–958.PubMedCrossRefGoogle Scholar
  142. Lichter, I. (1994). Accelerated titration of morphine for rapid relief of cancer pain. New Zealand Medical Journal, 107(990), 488–490.PubMedGoogle Scholar
  143. Lillemoe, K. D., Cameron, J. L., Kaufman, H. S., Yeo, C. J., Pitt, H. A., & Sauter, P. K. (1993). Chemical splanchnicectomy in patients with unresectable pancreatic cancer. A prospective randomized trial. Annals of Surgery, 217(5), 447–455.PubMedCrossRefGoogle Scholar
  144. Linton, S. L., & Melin, L. (1983). Applied relaxation in the management of cancer pain. Behavioral Psychotherapy, 11, 337–350.CrossRefGoogle Scholar
  145. Lobato, R. D., Madrid, J. L., Fatela, L. V., Sarabia, R., Rivas, J. J., & Gozalo, A. (1987). Intraventricular morphine for intractable cancer pain: rationale, methods, clinical results. Acta Anaesthesiology Scandinavica, Supplementum, 31, 68–74.CrossRefGoogle Scholar
  146. MacDonald, N., Der, L., Allan, S., & Champion, P. (1993). Opioid hyperexcitability: The application of alternate opioid therapy. Pain, 53(3), 353–355.PubMedCrossRefGoogle Scholar
  147. Malmberg, A. B., & Yaksh, T. L. (1992). Hyperalgesia mediated by spinal glutamate and substance P receptors blocked by spinal cyclooxygenase inhibition. Science, 92, 1276–1279.CrossRefGoogle Scholar
  148. Martin, R. S. (1989). Mortal values: healing, pain and suffering. In C. S. Hill & W. S. Fields (Eds.), Drug treatment of cancer pain in a drug oriented society (pp. 19–26). New York: Raven Press.Google Scholar
  149. Maunuksela, E. L., & Korpela, R. (1986). Double-blind evaluation of a lignocaine-prilocaine cream (EMLA) in children: Effect on the pain associated with venous cannulation. British Journal of Anaesthesiology, 58(11), 1242–1245.CrossRefGoogle Scholar
  150. Maxon, H., Thomas, S. R., Hertzberg, V. S., Schroder, L. E., Englaro, E. E., Samaratunga, R., Scher, H. I., Moulton, J. S., Deutsch, E. A., & Deutsch, K. F, (1992). Rhenium-186 hydroxyethylidene diphosphonate for the treatment of painful osseous metastases. Seminars in Nuclear Medicine, 22(1), 33–40.PubMedCrossRefGoogle Scholar
  151. Maxon, H. R., Deutsch, E. A., Thomas, S. R., Libson, K., Lukes, S. J., Williams, C. C., & Ali, S. (1988). Initial experience with 186-Re(Sn)-HEDP in the treatment of painful skeletal metastases. Journal of Nuclear Medicine, 29, 116.Google Scholar
  152. McCaffery, M., & Thorpe, D. M. (1989). Differences in perception of pain and the development of adversarial relationships among health care providers. In C. S. Hill & W. S. Fields (Eds.), Drug treatment of cancer pain in a drug oriented society (pp. 19–26). New York: Raven Press.Google Scholar
  153. McQuay, H. J., Carroll, D., Faura, C. C., Gavaghan, D. J., Hand, C. W., & Moore, R. A. (1990). Oral morphine in cancer pain: Influences on morphine and metabolite concentration. Clinical Pharmacology and Therapeutics, 48(3), 236–244.PubMedCrossRefGoogle Scholar
  154. McQuay, H. J., Jadad, A. R., Carroll, D., Faura, C., Glynn, C. J., Moore, R. A., & Liu, Y. (1992). Opioid sensitivity of chronic pain: A patient controlled analgesia method. Anaesthesia, 47, 757–767.PubMedCrossRefGoogle Scholar
  155. Melzack, R. (1975). The McGill pain questionnaire: Major properties and scoring methods. Pain, 1, 277–299.PubMedCrossRefGoogle Scholar
  156. Mercadante, S. (1993). Celiac plexus block versus analgesics in pancreatic cancer pain. Pain, 52(2), 187–192.PubMedCrossRefGoogle Scholar
  157. Miller, F., Whitcup, S., Sacks, M., & Lynch, P. E. (1985). Unrecognized drug dependence and withdrawal in the elderly. Drug Alcohol Depend, 15(1–2), 177–179.PubMedCrossRefGoogle Scholar
  158. Moertel, C. G., Shutte, A., & Reitemeier, R., (1974). Corticosteroid therapy of preterminal gastrointestinal cancer. Cancer, 33, 1607–1609.PubMedCrossRefGoogle Scholar
  159. Moinpour, C. M., Feigl, P., Metch, B., Hayden, K. A., Meyskens, F J., & Crowley, J. (1989). Quality of life endpoints in cancer clinical trials: review and recommendations. Journal of the National Cancer Institute, 81, 485–495.PubMedCrossRefGoogle Scholar
  160. Moinpour, C. M., Hayden, K. A., Thomson, I. M., Feigl, P., & Metch, B. (1991). Quality of life assessment in Southwest Oncology Group trials. In N. S. Tchekmedyian & D. Cella (Eds.), Quality of life in oncology practice and research (pp. 43–50). Williston Park: Dominus.Google Scholar
  161. Morgan, J., & Furst, D. E. (1986). Implications of drug therapy in the elderly. Clinics in Rheumatic Disease, 12, 244–251.Google Scholar
  162. Morton, A. R., Cantrill, J. A., Pillai, G. V., McMahon, A., Anderson, D. C., & Howell, A. (1988). Sclerosis of lytic bony metastases after aminohydroxyprpylidene bisphosphonate (APD) in patients with breast cancer. British Journal of Medicine, 297 772–773.CrossRefGoogle Scholar
  163. Moulin, D. E., Johnson, N. G., Murray, P. N., Geoghegan, M. F., Goodwin, V. A., & Chester, M. A. (1992). Subcutaneous narcotic infusions for cancer pain: treatment outcome and guidelines for use. Canadian Medical Association Journal, 146(6), 891–897.PubMedGoogle Scholar
  164. Moulin, D. E., Kreeft, J. H., Murray, P. N., & Bouquillon, A. I. (1991). Comparison of continuous subcutaneous and intravenous hydromorphone infusions for management of cancer pain. Lancet, 337, 465–468.PubMedCrossRefGoogle Scholar
  165. Myers, D. P., Lema, M. J., de Leon-Casasola, O. A., & Bacon, D. R. (1993). Intrapleural analgesia for the treatment of severe cancer pain in terminally ill patients. Journal of Pain and Symptom Management, 8(7), 505–510.PubMedCrossRefGoogle Scholar
  166. Ness, T. J., & Gebhart, G. E. (1990). Visceral pain: A review of experimental studies. Pain, 41, 167–234.PubMedCrossRefGoogle Scholar
  167. Nilsson, A., Danielson, K., Engberg, G., & Henneberg, S. (1990). EMLA for pain relief during arterial cannulation: A double-blind, placebo-controlled study of a lidocaine-prilocaine cream, Upsala Journal of Medical Sciences, 95(1), 87–94.PubMedCrossRefGoogle Scholar
  168. Nitescu, P., Appelgren, L., Linder, L. E., Sjoberg, M., Hultman, E., & Curelaru, I. (1990). Epidural versus intrathecal morphine-bupivicaine: Assessment of consecutive treatment is advanced cancer pain. Journal of Pain and Symptom Management, 5, 18–26.PubMedCrossRefGoogle Scholar
  169. Nurchi, G. (1984). Use of intraventricular and intrathecal morphine in intractable pain associated with cancer. Neurosurgery, 15(6), 801–804.PubMedCrossRefGoogle Scholar
  170. Obbens, E. A. M. T., Hill, C. S., Leavens, M. E., Ruthenbeck, S. S., & Otis, F. (1987). Intraventricular morphine administration for control of chronic cancer pain. Pain, 28, 61–68.PubMedCrossRefGoogle Scholar
  171. Oliver, D. J. (1988). Syringe drivers in palliative care: A review. Palliative Medicine, 2, 21–26.CrossRefGoogle Scholar
  172. Osborne, R. J., Joel, S. P., & Slevin, M. L. (1986). Morphine intoxication in renal failure: the role of morphine-6-glucuronide. British Journal of Medicine, 292, 1548–1549.CrossRefGoogle Scholar
  173. Parmelee, P. A., Smith, B., & Katz, I. R. (1993). Pain complaints and cognitive status among elderly institution residents. Journal of the American Geriatric Society, 41(5), 517–522.Google Scholar
  174. Piletta, P., Porchet, H. C., & Dayer, P. (1991). Central analgesic effect of acetaminophen but not of aspirin. Clinical Pharmacology and Therapeutics, 49, 350–354.PubMedCrossRefGoogle Scholar
  175. Plummer, J. L., Cherry, D. A., Cousins, M. J., Gourlay, G. K., Onley, M., & Evans, K. H. A. (1991). Long term spinal administration of morphine in cancer and non-cancer pain: a retrospective study. Pain, 44, 212–220.CrossRefGoogle Scholar
  176. Polatty, R. C., & Cooper, K. R. (1986). Respiratory failure after percutaneous cordotomy. Southern Medical Journal, 79, 367–379.CrossRefGoogle Scholar
  177. Polednak, A. P. (1994). Projected numbers of cancers diagnosed in the US elderly population, 1990 through 2030. American Journal of Public Health, 84(8), 1313–1316.PubMedCrossRefGoogle Scholar
  178. Popiela, T., Lucchi, R., & Giongo, F. (1989). Methylprednisolone as palliative therapy for female terminal cancer patients: The Methylprednisolone Female Preterminal Cancer Study Group. European Journal of Cancer and Clinical Oncology, 25(12), 1823–1829.PubMedCrossRefGoogle Scholar
  179. Portenoy, P. K., Southam, M., Gupta, S. K., Lapin, J., Layman, M., Inturrisi, C. E., & Foley, K. M. (1993). Transdermal fentanyl for cancer pain repeated dose pharmacokinetics. Anesthesiology, 78, 36–43.PubMedCrossRefGoogle Scholar
  180. Portenoy, R. K. (1987). Continuous intravenous infusions of opioid drugs. Medical Clinics of North America, 71, 233–241.PubMedGoogle Scholar
  181. Portenoy, R. K. (1991). Issues in the management of neuropathic pain. In A. Basbaum & J.-M. Besson (Eds.), Towards a new pharmacotherapy of pain (pp. 393–416). New York: Wiley.Google Scholar
  182. Portenoy, R. K. (1993a). Adjuvant analgesics in pain management. In D. Doyle, G. W. Hanks, & N. MacDonald (Eds.), Oxford textbook of palliative medicine (pp. 187–203). Oxford: Oxford University Press.Google Scholar
  183. Portenoy, R. K. (1993b). Inadequate outcome of opioid therapy for cancer pain. In R. B. Patt (Ed.), Cancer pain (pp. 119–128). Philadelphia: Lippincott.Google Scholar
  184. Portenoy, R. K., Foley, K. M., & Inturrisi, C. E. (1990). The nature of opioid responsiveness and its implications for neuropathic pain: New hypotheses derived from studies of opioid infusions. Pain, 43(3), 273–286.PubMedCrossRefGoogle Scholar
  185. Portenoy, R. K., Foley, K. M., Stulman, J., Khan, E., Adelhardt, J., Layman, M., Cerbone, D. J., & Inturrisi, C. E. (1991). Plasma morphine and morphine-6-glucuronide during chronic morphine therapy for cancer pain: Plasma profiles, steady state concentrations and the consequences of renal failure. Pain, 47, 13–19.PubMedCrossRefGoogle Scholar
  186. Portenoy, R. K., & Hagen, N. A. (1990). Breakthrough pain: Definition, prevalence and characteristics. Pain, 41(3), 273–281.PubMedCrossRefGoogle Scholar
  187. Portenoy, R. K., Miransky, J., Thaler, H. T., Hornung, J., Bianchi, C., Cibas-Kong, I., Feldhamer, E., Lewis, M., Matamoros, I., Sugar, M. Z., Olivieri, A., & Foley, K. M. (1992). Pain in ambulatory patients with lung or colon cancer: Prevalence, characteristics and impact. Cancer, 70, 1616–1624.PubMedCrossRefGoogle Scholar
  188. Porter, A. T., McEwan, A. J., Powe, J. E., Reid, R., McGowan, D. G., Lukka, H., Sathyanarayana, J. R., Yakemchuk, V. N., Thomas, G. M., & Erlich, L. E., (1993). Results of a randomized Phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer. International Journal of Radiation Oncology, Biology, Physics, 25(5), 805–813.PubMedCrossRefGoogle Scholar
  189. Porter, J., & Jick, H. (1980). Addiction rare in patients treated with narcotics (letter). New England Journal of Medicine, 302, 123.PubMedGoogle Scholar
  190. Reuben, D. B., Mor, V., & Hiris, J. (1988). Clinical symptoms and length of survival in patients with terminal cancer. Archives of Internal Medicine, 148(7), 1586–1591.PubMedCrossRefGoogle Scholar
  191. Rhiner, M., Ferrell, B. R., Ferrell, B. A., & Grant, M. M. (1993). A structured nondrug intervention program for cancer pain. Cancer Pract, 1(2), 137–143.PubMedGoogle Scholar
  192. Robertson, D. H. (1983). Transsacral neurolytic nerve block: An alternative approach to intractable perineal pain. British Journal of Anaesthesiology, 55(9), 873–875.CrossRefGoogle Scholar
  193. Robinson, R. G., Preston, D. F., Spicer, J. A., & Baxter, K. G. (1992). Radionuclide therapy of intractable bone pain: Emphasis on strontium-89. Seminars in Nuclear Medicine, 22(1), 28–32.PubMedCrossRefGoogle Scholar
  194. Roquefeil, B., Benezich, J., Blanchet, P., Baiter, C., Frerebeau, P., & Gros, C. (1984). Intraventricular administration of morphine in patients with neoplastic intractable pain. Surgical Neurology, 21, 155–158.CrossRefGoogle Scholar
  195. Rosomoff, H. L., Carroll, F., & Brown, J. (1965). Percutaneous radiofrequency cervical cordotomy: Technique. Journal of Neurosurgery, 23, 639–644.PubMedCrossRefGoogle Scholar
  196. Roth, A., & Kolaric, K. (1986). Analgesic activity of calcitonin in patients with painful osteolytic metastases of breast cancer. Oncology, 43, 283–287.PubMedCrossRefGoogle Scholar
  197. Ryynanen, O. P., Kivela, S. L., Honkanen, R., Laippala, P., & Saano, V. (1993). Medications and chronic diseases as risk factors for falling injuries in the elderly. Scandinavian Journal of Social Medicine, 21(4), 264–271.PubMedGoogle Scholar
  198. Sawe, J., Hansen, J., Ginman, C., Hartvig, P., Jakobsson, P. A., Nilsson, M. I., Rane, A., & Anggard, E. (1981). Patient-controlled dose regimen of methadone for chronic cancer pain. British Medical Journal (Clinical Research Ed.), 282(6266), 771–773.CrossRefGoogle Scholar
  199. Sawe, J., Svensson, J. O., & Odar-Cederlof, I. (1985). Kinetics of morphine in patients with renal failure (letter). The Lancet, 2, 211.CrossRefGoogle Scholar
  200. Scapa, E., Horowitz, M., Avtalion, J., Waron, M., & Eschar, J. (1992). Appreciation of pain in the elderly. Israel Journal of Medical Science, 28(2), 94–96.Google Scholar
  201. Schuster, C. R. (1989). Does treatment of cancer pain with narcotics produce junkies? In C. S. Hill & W. S. Fields (Eds.), Drug treatment of cancer pain in a drug oriented society (pp. 1–3). New York: Raven Press.Google Scholar
  202. Sear, J. W., Hand, C. W., & Moore, R. A. (1989). Studies on morphine disposition: Plasma concentrations of morphine and its metabolites in anesthetized middle-aged and elderly surgical patients. Journal of Clinical Anesthesia, 1(3), 164–169.PubMedCrossRefGoogle Scholar
  203. Shepherd, K. (1990). Review of a controlled-release morphine preparation. In K. M. Foley, J. J. Bonica, & V. Ventafridda (Eds.), Second International Congress on Cancer Pain (pp. 191–202). New York: Raven Press.Google Scholar
  204. Shorr, R. I., Griffin, M. R., Daugherty, J. R., & Ray, W. A. (1992). Opioid analgesics and the risk of hip fracture in the elderly: Codeine and propoxyphene. Journal of Gerontology, 47(4), 111–115.CrossRefGoogle Scholar
  205. Shortsleeve, M. J., & Levine, M. S. (1992). Herpes esophagitis in otherwise healthy patients: Clinical and radiographic findings. Radiology, 182(3), 859–861.PubMedGoogle Scholar
  206. Sindou, M., Fisher, G., & Mansuy, L. (1976). Posterior spinal rhizotomy and selective posterior rhizidiotomy. Progress in Neurosurgical Surgery, 7, 201–250.Google Scholar
  207. Singleton, M. A., Rosen, J. I., & Fisher, D. M. (1988). Pharmacokinetics of fentanyl in the elderly. British Journal of Anaesthesiology, 60(6), 619–622.CrossRefGoogle Scholar
  208. Sjoberg, M., Appelgren, L., Einarsson, S., Hultman, E., Under, L. E., Nitescu, P., & Curelaru, I. (1991). Long-term intrathecal morphine and bupivacaine in “refractory” cancer pain: Results from the first series of 52 patients. Acta Anaesthesiologica Scandinavica, 35(1), 30–43.PubMedCrossRefGoogle Scholar
  209. Smales, O. R., Smales, E. A., & Sanders, H. G. (1993). Flunitrazepam in terminal care. Journal of Paediatrics and Child Health, 29(1), 68–69.PubMedCrossRefGoogle Scholar
  210. Soliman, I. E., Broadman, L. M., Hannallah, R. S., & McGill, W. A. (1988). Comparison of the analgesic effects of EMLA (eutectic mixture of local anesthetics) to intradermal lidocaine infiltration prior to venous cannulation in unpremedicated children. Anesthesiology, 68(5), 804–806.PubMedCrossRefGoogle Scholar
  211. Storey, P., Hill, H. H., St. Louis, R., & Tarver, E. E. (1990). Subcutaneous infusions for control of cancer symptoms. Journal of Pain and Symptom Management, 5, 33–41.PubMedCrossRefGoogle Scholar
  212. Stuart, G., & Cramond, T. (1993). Role of percutaneous cervical cordotomy for pain of malignant origin. Medical Journal of Australia, 158(10), 667–670.PubMedGoogle Scholar
  213. Swanson, G., Smith, J., Bulich, R., New, P., & Shiftman, R. (1989). Patient-controlled analgesia for chronic cancer pain in the ambulatory setting: A report of 117 patients. Journal of Clinical Oncology, 7(12), 1903–1908.PubMedGoogle Scholar
  214. Sykes, N. P. (1991). Oral naloxone in opioid associated constipation. Lancet, 337, 1475.PubMedCrossRefGoogle Scholar
  215. Sykes, N. P. (1993). Constipation and diarrhoea. In D. Doyle, G. W. Hanks, & N. MacDonald (Eds.), Oxford textbook of palliative medicine (pp. 299–310). Oxford: Oxford University Press.Google Scholar
  216. Syversen, J. H., Mollestad, E., & Semb, L. S. (1976). Emepronium bromide (Cetiprin) as a postoperative spasmolytic agent in transvesical prostatectomy. Scandinavian Journal of Urology and Nephrology, 10(3), 201–203.PubMedGoogle Scholar
  217. Szeto, H. H., Inturrisi, C. E., Houde, R., Saal, R., Cheigh, J., & Reidengerg, M. M. (1977). Accumulation of normeperidine an active metabolite of meperidine, in patients with renal failure or cancer. Annals of Internal Medicine, 86(6), 738–741.PubMedCrossRefGoogle Scholar
  218. Tannock, I. Gospodarowicz, M., Meakin, W., Panzarella, T., Stewart, L., & Rider, W. (1989). Treatment of metastatic prostatic cancer with low-dose prednisone: evaluation of pain and quality of life as pragmatic indices of response. Journal of Clinical Oncology, 7, 590–597.PubMedGoogle Scholar
  219. Tasker, R. R., Tsuda, T., & Howrylyshn, P. (1988). Percutaneous cordotomy—The lateral high cervical technique. In H. H. Schmidek & W. H. Sweet (Eds.), Operative neurosurgical technique indications, methods and results (pp. 1191–1205). New York: Grune & Stratton.Google Scholar
  220. Thiebaud, D., Leyvraz, S., von Fliedner, V., Perey, L., Cornu, P., Thiebaud, S., & Burckhardt, P. (1991). Treatment of bone metastases from breast cancer and myeloma with pamidronate. European Journal of Cancer, 27(1), 37–41.PubMedCrossRefGoogle Scholar
  221. Torebjork, H. E., Ochoa, J. L., & Schady, W. (1984). Referred pain from intraneural stimulation of muscle fascicles in the median nerve. Pain, 18, 145–156.PubMedCrossRefGoogle Scholar
  222. Trissel, L. A., Xu, Q., Martinez, J. F., & Fox, J. L. (1994). Compatibility and stability of ondansetron hydrochloride with morphine sulfate and with hydromorphone hydrochloride in 0.9% sodium chloride injection at 4, 22, and 32 degrees C. American Journal of Hospital Pharmacy, 51(17), 2138–2142.PubMedGoogle Scholar
  223. Truog, R. D., Berde, C. B., Mitchell, C., & Greir, H. E. (1992). Barbiturates in the care of the terminally ill. New England Journal of Medicine, 327(23), 1678–1682.PubMedCrossRefGoogle Scholar
  224. Turner, J. H., & Claringbold, P. G. (1991). A phase II study of treatment of painful multifocal skeletal metastases with single and repeated dose samarium-153 ethylenediaminetetramethylene phosphonate. European Journal of Cancer, 27(9), 1084–1086.PubMedCrossRefGoogle Scholar
  225. Turner, J. H., Claringbold, B. G., Heatherington, E. L., Sorby, P., & Martindal, A. A. (1989). A phase I study of samarium-153 ethylenedi-amenetetramethylene phosphonate therapy for disseminated skeletal metastases. Journal of Clinical Oncology, 7, 1926–1931.PubMedGoogle Scholar
  226. Twycross, R. G., & Fairfield, S. (1982). Pain in far-advanced cancer. Pain, 14, 303–310.PubMedCrossRefGoogle Scholar
  227. Twycross, R. G., & Lack, S. A. (1984). Symptom control in far-advanced cancer: Pain relief. London: Pitman.Google Scholar
  228. Twycross, R. G., & Lack, S. A. (1990). Therapeutics in terminal cancer (2nd ed.). Edinburgh: Churchill Livingston.Google Scholar
  229. Vane, J. R. (1971). Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biology, 234, 231–238.Google Scholar
  230. van Holten-Verzantvoort, A. T. M., Zwinderman, A. H., Aaronson, N. K., Hermans, J., van Emmerik, B., van Dam, F., van den Bos, B., Bijvoet, O. L., & Cleton, F. J. (1991). The effect of supportive pamidronate treatment on aspects of quality of life of patients with advanced breast cancer. European Journal of Cancer, 27(5), 544–549.PubMedCrossRefGoogle Scholar
  231. van Holten-Verzantvoort, A. T., Kroon, H. M., Bijvoet, O. L., Cleton, F. J., Beex, L. V., Blijham, G., Hermans, J., Neijt, J. P., Papapoulos, S. E., & Sleeboom, H. P., (1993). Palliative pamidronate treatment in patients with bone metastases from breast cancer. Journal of Clinical Oncology, 11(3), 491–498.PubMedGoogle Scholar
  232. Ventafridda, V., Ripamonti, C., Caraceni, A., Spoldi, E., Messina, L., & De Conno, F. (1990a). The management of inoperable gastrointestinal obstruction in terminal cancer patients. Tumori, 76, 389–393.PubMedGoogle Scholar
  233. Ventafridda, V., Ripamonti, C., De Conno, F., Tamburini, M., & Cassileth, B. R. (1990b). Symptom prevalence and control during cancer patients’ last days of life. Journal of Palliative Care, 6(3), 7–11.PubMedGoogle Scholar
  234. Ventafridda, V., Tamburini, M., Caraceni, A., DeConno, F., & Naldi, F. (1987). A validation study of the WHO method for cancer pain relief. Cancer, 59, 851–856.CrossRefGoogle Scholar
  235. Von Roenn, J. H., Cleeland, C. S., Gonin, R., Hatfield, A., & Pandya, K. J. (1993). Physician’s attitudes and practice in cancer pain management: A survey from the Eastern Cooperative Oncology Group. Annals of Internal Medicine, 119(2), 121–126.CrossRefGoogle Scholar
  236. Waldman, S. D., Allen, M. L., & Cronen, M. C. (1989). Subcutaneous tunneled intrapleural catheters in the long-term relief of right upper quadrant pain of malignant origin. Journal of Pain and Symptom Management, 4, 86–89.PubMedCrossRefGoogle Scholar
  237. Waldmann, C. S., Eason, J. R., Rambohu, I. E., & Hanson, G. C. (1984). Serum morphine levels. A comparison between continuous subcutaneous infusions and intravenous infusions in postoperative patients. Anesthesia, 39(8), 768–771.CrossRefGoogle Scholar
  238. Wanzer, S. H., Federman, D. D., Adelstein, S. J., Cassel, C. K., Cassem, E. H., Cranford, R. E., Hook, E. W., Lo, B., Moertel, C. G., & Safar, P., (1989). The physicians responsibility toward hopelessly ill patients—a second look. New England Journal of Medicine, 120, 844–849.CrossRefGoogle Scholar
  239. Ward, S. E., Goldberg, N., Miller-McCauley, V., Mueller, C., Nolan, A., Pawlik-Plank, D., Robbins, A., Stormoen, D., & Weissman, D. E. (1993). Patient related barriers to management of cancer pain. Pain, 52, 319–324.PubMedCrossRefGoogle Scholar
  240. Warrell, R. P., Lovett, D., Dilmanian, F. A., Schnieder, R., & Heelan, R. T. (1993). Low-dose gallium nitrate for prevention of osteolysis in myeloma: results of a pilot randomized study. Journal of Clinical Oncology, 11(12), 2443–2450.PubMedGoogle Scholar
  241. Watts, S. J., Alexander, L. C., Fawcett, K., Check, F. J., & Abnrashed, A. (1986). Herpes simplex esophagitis in a renal transplant patient treated with cyclosporine A: A case report. American Journal of Gastroenterology, 81(3), 185–188.PubMedGoogle Scholar
  242. Weinberg, D. S., Inturrisi, C. E., Reidenberg, B., Moulin, D., Nip, T. J., Wallenstein, S. L., Houde, R. W, & Foley, K. M. (1988). Sublingual absorption of selected opioid analgesics. Clinical Pharmacology and Therapeutics, 44, 335–342.PubMedCrossRefGoogle Scholar
  243. Weissman, D. E., Gutmann, M., & Dahl, J. L. (1991). Physician cancer pain education: A report from the Wisconsin Cancer Pain Initiative. Journal of Pain Symptom Management, 6(7), 445–448.PubMedCrossRefGoogle Scholar
  244. Weissman, D. E., & Haddox, J. D. (1989). Opioid pseudoaddiction—an iatrogenic syndrome. Pain, 36, 363–366.PubMedCrossRefGoogle Scholar
  245. Welling, L. R., & Watson, W. A. (1990). The emergency department treatment of dyspepsia with antacids and oral lidocaine. Annals of Emergency Medicine, 19(7), 785–788.PubMedCrossRefGoogle Scholar
  246. Whitcomb, D. C., & Block, G. D. (1994). Association of acetaminophen hepatotoxicity with fasting and ethanol use. Journal of the American Medical Association, 272(23), 1845–1850.PubMedCrossRefGoogle Scholar
  247. Wig, J., & Johl, K. S. (1990). Our experience with EMLA cream (for painless venous cannulation in children). Indian Journal of Physiology and Pharmacology, 34(2), 130–132.PubMedGoogle Scholar
  248. Wilcox, J. C., Corr, J., Shaw, J., Richardson, M., & Caiman, K. C. (1984). Prednisolone as appetite stimulant in patients with cancer. British Medical Journal, 288, 27.Google Scholar
  249. Wilkinson, T. J., Robinson, B. A., Begg, E. J., Duffull, S. B., Ravenscroft, P. J., & Schneider, J. J. (1992). Pharmacokinetics and efficacy of rectal versus oral sustained-release morphine in cancer patients. Cancer Chemotherapy and Pharmacology, 31(3), 251–254.PubMedCrossRefGoogle Scholar
  250. Wilier, J., DeBroucker, T., Bussel, B., Robi-Brami, A., & Harrewyn, J. (1989). Central analgesic effect of ketoprofen in humans: Electrophysiologic evidence for a supraspinal mechanism in a double-blind and cross-over study. Pain, 38, 1–8.CrossRefGoogle Scholar
  251. World Health Organization. (1986). Cancer pain relief Geneva: World Health Organization.Google Scholar
  252. World Health Organization. (1990). Cancer pain relief and palliative care. Geneva: World Health Organization.Google Scholar
  253. Zfass, A. M., McHenry, L. J., & Sanyal, A. J. (1993). Nonsteroidal antiinflammatory drug-induced gastroduodenal lesions: prophylaxis and treatment. Gastroenterologist, 1(2), 165–169.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Nathan I. Cherny
    • 1
  • Beth Popp
    • 2
  1. 1.Department of Medical OncologyShaare Zedek Medical CenterJerusalemIsrael
  2. 2.Pain ServiceMemorial Sloan Kettering Cancer CenterNew YorkUSA

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