The Role of FasL and TNF in the Homeostatic Regulation of Immune Responses

  • David H. Lynch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 406)


The Fas/APO-1 protein (CD95) is expressed on a wide variety of cells and tissues, including monocytes, myelocytes, activated or transformed lymphocytes, thymus, liver, ovary and heart1. It is a member of the TNF receptor/nerve growth factor receptor family of cell-surface receptors2–4. Early studies had indicated that ligation of this receptor in mAb resulted in the death of certain transformed cell lines via a process known as apoptosis5, 6 This process is characterized by cytoplasmic condensation, plasma membrane convolution, nuclear condensation and DNA fragmentation7.


Homeostatic Regulation Normal Immune Response Progressive Depletion Cytoplasmic Condensation Progressive Deletion 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • David H. Lynch
    • 1
  1. 1.Immunex Corp.SeattleUSA

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