Abstract
The Fas/APO-1 protein (CD95) is expressed on a wide variety of cells and tissues, including monocytes, myelocytes, activated or transformed lymphocytes, thymus, liver, ovary and heart1. It is a member of the TNF receptor/nerve growth factor receptor family of cell-surface receptors2–4. Early studies had indicated that ligation of this receptor in mAb resulted in the death of certain transformed cell lines via a process known as apoptosis5, 6 This process is characterized by cytoplasmic condensation, plasma membrane convolution, nuclear condensation and DNA fragmentation7.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
I. Watanabe-Fukunaga R, Brannan CI, Itoh N, Yonehara S, Copeland NG, Jenkins NA, Nagata S: The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol 148: 1274, 1992
Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S-I, Sameshima M, Hase A, Seto Y, Nagata S: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66: 233, 1991
Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S: Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356: 314. 1992
Smith CA, Farrah T, Goodwin RG: The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 76: 959, 1994
Yonehara S, Ishii A, Yonehara M: A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J Exp Med 169: 1747. 1989
Trauth BC, Klas C, Peters AMJ, Matzku S, Möller P, Falk W, Debatin K-M, Krammer PH: Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245: 301, 1989
Wylie AH, Kerr JFR, Currie AR: Cell death: The significance of apoptosis. Int Rev Cytol 68: 251, 1980
Kobayashi S, Hirano T, Kakinuma M, Uede T: Transcriptional repression and differential splicing of Fas mRNA by early transposon (ETn) insertion in autoimmune 1pr mice. Biochem Biophys Res Commun 191: 617, 1993
Adachi M, Watanabe-Fukunaga R, Nagata S: Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of 1pr mice. Proc Natl Acad Sci USA 90: 1756, 1993
Cohen PL, Eisenberg RA: Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease. Ann Rev Immunol 9: 243, 1991
Allen RD, Marshall JD, Roths JB, Sidman CD: Differences defined by bone marrow transplantation suggest that 1pr and gld are mutations of genes encoding an interacting pair of molecules. J Exp Med 172: 1367, 1990
Ramsdell F, Seaman MS, Miller RE, Tough TW, Alderson MR, Lynch DH: gld/gld mice are unable to express a functional ligand for Fas. Eur J Immunol 24: 928, 1994
Lynch DH, Watson ML, Alderson MR, Baum PR, Miller RE, Tough T, Gibson M, Davis-Smith T, Smith CA, Hunter K, Bhat D, Din W, Goodwin RG, Seldin MF: The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity 1: 131, 1994
Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S: Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76: 969, 1994
Alderson MR, Tough TW, Braddy S, Davis-Smith T, Roux E, Schooley K, Miller RE, Lynch DH: Regulation of apoptosis and T cell activation by Fas-specific mAb. Int Immunol 6: 1799, 1994
Alderson MR, Tough TW, Davis-Smith T, Braddy S, Falk B, Schooley KA, Goodwin RG, Smith CA, Ramsdell F, Lynch DH: Fas ligand mediates activation-induced cell death in human T lymphocytes. J Exp Med 181: 71, 1995
Zheng LX, Fisher G, Miller RE, Peschon J, Lynch DH, Lenardo MJ: Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 377: 348, 1995
Itoh N, Nagata S: A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem 268: 10932, 1993
Tartaglia LA, Ayres TM, Wong GHW, Goeddel DV: Anovel domain within the 55 kd TNF receptor signals cell death. Cell 74: 845, 1993
Tartaglia LA, Rothe M, Hu YF, Goeddel DV: Tumor necrosis factor’s cytotoxic activity is signaled by the p55 TNF receptor. Cell 73: 213, 1993
Ameisen JC: Programmed cell death and AIDS: from hypothesis to experiment. Immunol Today 13: 388, 1992
Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA, Herzenberg LA: Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 181: 2029, 1995
Badley AD, McElhinny JA, Leibson PA, Lynch DH, Alderson MR, Paya CV: Upregulation of Fas-ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of uninfected T lymphocytes. J Virol 70: 199, 1996
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer Science+Business Media New York
About this chapter
Cite this chapter
Lynch, D.H. (1996). The Role of FasL and TNF in the Homeostatic Regulation of Immune Responses. In: Gupta, S., Cohen, J.J. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VI. Advances in Experimental Medicine and Biology, vol 406. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0274-0_14
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0274-0_14
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0276-4
Online ISBN: 978-1-4899-0274-0
eBook Packages: Springer Book Archive