Skip to main content

Sleep Facilitating Effects of Vitamin B12

  • Chapter
Sleep—Wake Disorders


Recent experiments (Kamgar-Paris 1983, Okawa 1990) have shown that vitamin B12 (Vit. B12) has therapeutic effects on circadian rhythm sleep disorders, such as delayed sleep phase syndrome (DSPS) and non-24 hours sleep wake rhythm disorder (Non-24). Regarding the mechanisms of therapeutic action of Vit. B12 on circadian rhythms sleep wake disorders, many study consider its effects on the phase or period of circadian rhythms and on photo sensitivity. But at the present time the definite mechanisms of action are still unclear.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others


  • Bereger, R.J., Palca, J.W. and Walker, J.M., 1988, Correlations between body temperature, metabolicrate and slow wave sleep, Neurosci. Lett. 86: 230–234.

    Article  Google Scholar 

  • Honma, K., Honma, S., Kohsaka, M., Morita, N. and Fukuda, N., 1991, Does metylcobalamin (vitamin B12) increase the light sensitivity of human circadian clock?, Jpn. J. Psychiat. Neurol. 45 (1): 171–172.

    CAS  Google Scholar 

  • Home, J.A. and Schackell, B.S., 1987, Slow wave sleep elevation after body heating: Proximity to sleep and effects of aspirin, Sleep. 10 (4): 383–392.

    Google Scholar 

  • Inoue, S., Honda, K., Uchizono, K., Ueno, R. and Hayaishi, O., 1984, Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats, Proc. Natl. Acad. Sci. USA. 81: 6240–6244.

    Article  PubMed  CAS  Google Scholar 

  • Inoue, S. and Honda, K., 1991, Sleep-promoting and temperature modulatory activities of vitamin B12 in rats, Jpn. J. Psychiatry. Neurol. 45: 943–944.

    Google Scholar 

  • Inoue, S., 1993, Sleep-promoting effects of vitamin B12, in: Sleep—wake rhythm disorders, (K. Takahasi, ed.), pp. 1–6, Intermed, Tokyo, (in Japanese).

    Google Scholar 

  • Kamgar-Parsi, B., Wehr, T.A. and Gillin, J.C., 1983, Successful treatment of human non-24-hour sleep—wake cycle syndrome, Sleep. 6: 257–262.

    PubMed  CAS  Google Scholar 

  • Ohta, T., Ando, K., Iwata, T., Ozaki, N., Kayukawa, Y, Terashima, M., Okada, T. and Kasahara, Y, 1991, Treatment of persistent sleep—wake schedule disorders in adolescent with methylcobalamin (vitamin B12), Sleep. 14(5): 414–418.

    PubMed  CAS  Google Scholar 

  • Okawa, M., Mishima, K., Nanami, T., Shimizu, T., Iijima, S., Hishikawa, Y and Takahashi, K., 1990, Vitamin B12 treatment for sleep—wake rhythm disorders, Sleep. 13(1): 15–23.

    PubMed  CAS  Google Scholar 

  • Sakamoto, T., Nakazawa, Y, Utiyama, N. and Tutiyama, Y, 1993, Sleep and temperature rhythm in the elderly, Clinical Psychiatry. 35(2): 145–152. (in Japanese).

    Google Scholar 

  • Takahashi, K., Morita, N., Mishima, K., Kanako, M, Higuti, T., Sakamoto, K., Sasaki, M, Okawa, T., Yamadera, H., Okamoto, N., Ohta, T., Sugita, Y, Tamiya, M., Kotorii, T. and Takahashi, S., 1994, A multicenter study on sleep—wake rhythm disorders in Japan, Clinical Psychiatry. 36(3): 275–284. (in Japanese).

    Google Scholar 

  • Tsujimaru, S., Ida, Y, Satoh, H., Egami, H., Shirao, I., Mukasa, H. and Nakazawa, Y, 1992, Vitamin B12 accelerates re-entrainment of activity rhythms in rats, Life Science. 50: 1843–1850.

    Article  CAS  Google Scholar 

  • Uchiyama, M., Mayer, G., Okawa, M. and Meier-Ewert, K., 1995, Effects of vitamin B12 on human circadian body temperature rhythm, Neurosci. Lett. 192: 1–4.

    Article  PubMed  CAS  Google Scholar 

  • Yamazaki, J., Sugishita, M., Moriya, Y, Isojima, G., Ohshima, H., Yamazaki, O., Takeda, Y, Yamauchi, T., Takeshima, M. and Takahashi, Y, 1991, The effects of vitamin B12 on the suppression of melatonin secretion under illumination, Jpn. J. Psychiat. Neurol. 45(1): 169–170.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media New York

About this chapter

Cite this chapter

Itoh, H., Ozone, M., Sasaki, M. (1997). Sleep Facilitating Effects of Vitamin B12. In: Meier-Ewert, K., Okawa, M. (eds) Sleep—Wake Disorders. Springer, Boston, MA.

Download citation

  • DOI:

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0247-4

  • Online ISBN: 978-1-4899-0245-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics