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Orally Active DACH-Pt (IV) Compounds

  • Yoshinori Kidani
  • Ryoichi Kizu
  • Motoichi Miyazaki
  • Masahide Noji
  • Akio Matsuzawa
  • Yasutaka Takeda
  • Nachio Akiyama
  • Masazumi Eriguchi

Abstract

Since the discovery of the antitumor activity of cisplatin by Rosenberg, et al.1 in 1969, many attempts have been made to prepare highly antitumor active Pt complexes without severe toxicities. The authors discovered a simple preparative separation method of 1,2-diaminocyclohexane (dach) geometrical isomers, cis and trans2, by Nickel complex formation and trans isomers were resolved into d and l optical isomers by the conventional method.

Keywords

Antitumor Activity Partition Coefficient Intestinal Membrane High Antitumor Activity Collateral Sensitivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Yoshinori Kidani
    • 1
  • Ryoichi Kizu
    • 2
  • Motoichi Miyazaki
    • 2
  • Masahide Noji
    • 1
  • Akio Matsuzawa
    • 3
  • Yasutaka Takeda
    • 3
  • Nachio Akiyama
    • 3
  • Masazumi Eriguchi
    • 3
  1. 1.Faculty of Pharmaceutical SciencesNagoya City UniversityMizuho-ku, Nagoya 467Japan
  2. 2.Faculty of Pharmaceutical SciencesKanazawa UniversityKanazawa 920Japan
  3. 3.The Institute of Medical ScienceThe University of TokyoMinato-ku, Tokyo 108Japan

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