Combination of Different Platinum Compounds: Issues, Strategies, and Experience

  • Franco M. Muggia


The rationale for combination of cisplatin and carboplatin is based primarily on 1) a steep dose-response in antitumor effects of platinums, and 2) the widely different dose-limiting toxicities for cisplatin and carboplatin. With the introduction of several new analogues, the rationale of lack of complete cross-resistance becomes increasingly attractive. In fact, both preclinical and clinical data have been assembled in support of the hypothesis that combinations of platinum compounds may lead to improved therapeutic effects. We review here the issues concerned with specific platinum combinations and illustrate possible strategies to test such combinations, and preliminary clinical experience.


Ovarian Cancer Germ Cell Tumor Platinum Compound Buccal Cell Dose Intensification 


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Franco M. Muggia
    • 1
  1. 1.Medical OncologyUSC-Norris Cancer CenterLos AngelesUSA

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