Combination Therapy with Cisplatinum and EGF Receptor Blockade

  • John Mendelsohn
  • Zhen Fan
  • Jose Baselga


Simultaneous treatment of xenografts of human A431 vulvar squamous carcinoma cells and MDA-468 breast adenoma cells with anti-EGF receptor monoclonal antibody (MAb) plus maximal tolerated doses of cisplatinum (cis-DDP) results in eradication of well-established tumors that are resistant to either therapy when administered alone. Hypotheses that could explain this synergistic antitumor activity are presented. We suggest that activation of dual checkpoints by the combination therapy results in cell death.


Epidermal Growth Factor Receptor A431 Cell Receptor Monoclonal Antibody Combination Of225 Synergistic Antitumor Activity 


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • John Mendelsohn
    • 1
  • Zhen Fan
    • 1
  • Jose Baselga
    • 1
  1. 1.Memorial Sloan-Kettering Cancer Center and Cornell University Medical CollegeNew YorkUSA

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