Biochemical Characteristics of Oxygen-Induced and Low K+ Medium-Induced Apoptotic Neuronal Death
Neuronal cell death is thought to be an important phenomenon not only in the developmental but also in the post-matured stages of PNS and CNS. In the developmental stages, massive neuronal death is observed at specific periods, e.g. the immediately after the arrival of axons to the postsynaptic target fields. This phenomenon is precicely programmed in the developing nervous system and called programmed (or apoptotic) neuronal death. Recent studies also suggest that similer apoptotic neuronal death occurs in the matured nervous system, e.g. neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases, and aging. Thus, it is expected that the study of apoptosis in the nervous system give us useful clues to know how the neuronal net work are constructed in the development and why the neurodegenerateve diseases and brain aging occur.
KeywordsPC12 Cell Neuronal Death Cerebellar Granule Neuron Prevent Cell Death Apoptotic Neuronal Death
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