Ciliary Neurotrophic Factor (CNTF): Possible Implications in the Pathogenesis of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder, primarily affecting both upper and lower motor neurons. The median age of onset is around 68 years, and median survival approximately 2 years, although with significant variability1. The pathogenesis is unknown, but the recognition of mutations in the gene for copper/zinc Superoxide dismutase (SOD-1)2 in a proportion of patients (around 1–2% of all cases), almost all of whom have a family history of the condition, has provided fruitful avenues of research3. Nevertheless, the mechanism by which these mutations lead to the expression of the disease is not yet established4,5.
KeywordsAmyotrophic Lateral Sclerosis Motor Neuron Nerve Growth Factor Motor Neuron Disease Lower Motor Neuron
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