Abstract
Disruption of cellular regulation of calcium has long been implicated in the mechanism of neruonal death following cerebral ischemia and reperfusion9,17. While much research has been directed at the potential role of calcium influx in ischemia, less attention has been paid to other mechanisms of calcium regulation that may be altered. We are investigating the possibility that altered storage and release of Ca2+ from the endoplasmic reticulum (ER) contributes to ischemic neuronal death.
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Perry, D.C., Wei, H., Wei, W., Bredesen, D.E. (1996). Intracellular Calcium Stores and Ischemic Neuronal Death. In: Fiskum, G. (eds) Neurodegenerative Diseases. GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0209-2_44
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DOI: https://doi.org/10.1007/978-1-4899-0209-2_44
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