A Model for the Expression of Different Glutamate Transporter Proteins from a Rat Astrocyte-Type Glutamate Transporter Gene

  • Raymond S. Roginski
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)


The mammalian brain uses the largest variety of mechanisms of gene expression of any organ to generate many different proteins from a single gene. Nowhere is this phenomenon more obvious and relevant than in the families of genes encoding the ionotropic glutamate (Glu) receptors (iGluRs)1. The differences introduced usually affect the physiologic role of the variant protein. For example, the gene encoding the NMDAR1 iGluR makes nine splice variants2 that display distinct properties when expressed in exogenous systems2,3. A second example involves RNA editing of the GluR2 primary transcript that results in the incorporation of the amino acid (AA) arginine (R) instead of glutamine (Q) at the R/Q site in the putative intramembranous4 domain of the iGluRs. This alteration abolishes the calcium permeability of the edited GluR2 subunit.


Glutamate Transporter mRNA Species GluT Gene Robert Wood Johnson Medical School Glial Cell Process 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Raymond S. Roginski
    • 1
  1. 1.Department of AnesthesiaUMDNJ-Robert Wood Johnson Medical SchoolNew BrunswickUSA

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