The Protective Action of Nitrone-Based Free Radical Traps in Neurodegenerative Diseases

  • Robert A. Floyd
Part of the GWUMC Department of Biochemistry and Molecular Biology Annual Spring Symposia book series (GWUN)

Abstract

Nitrone-based free radical traps (NRTs) have been shown to protect in several experimental animal models of neurodegenerative diseases and to mitigate other parameters associated with the aging process in brain. Since the prototype NRTs were first utilized in analytical chemistry to trap and characterize the presence of free radicals in chemical and biochemical systems, it is the simplest hypothesis that they protect by trapping crucial free radicals involved in the oxidative damage that occurs in animal models of neurodegenerative diseases. This remains to be rigorously proven. Pertinent data supporting this concept are presented in a framework of the knowledge accrued from studies on oxidative damage in brain.

Keywords

Ischemia Dopamine Lactate Glutathione Superoxide 

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Robert A. Floyd
    • 1
  1. 1.Oklahoma Medical Research FoundationOklahoma CityUSA

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