Global Brain Ischemia and Reperfusion: Translation Initiation Factors
Cardiopulmonary resuscitation for victims of cardiac arrest, both within and outside of the hospital, succeeds in restoring spontaneous circulation in about 70,000 patients a year in the United States. At least 60% of these patients subsequently die in the hospital as a result of extensive brain damage; only 3–10% of resuscitated patients are finally able to resume their former lifestyles1. These statistics may even be optimistic; in a recent report of data for out-of-hospital cardiac arrest, out of a total of 1,445 patients only 10 survived to discharge with the majority of these survivors (6/10) having a spontaneous pulse en route to the hospital2. Clearly, patients do not often escape cardiac arrest and resuscitation without initiation of brain injury mechanisms, and there are currently no therapeutic approaches that are convincingly effective in ameliorating the brain damage that usually accompanies this clinically important brain insult.
KeywordsCardiac Arrest Translation Initiation Serine Phosphorylation Eukaryotic Initiation Factor Global Brain Ischemia
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