Long-Term Expression of Proenkephalin and Prodynorphin in the Rat Brain after Systemic Administration of Kainic Acid — an in Situ Hybridization Study
Kainic acid (KA) is a glutamate analog that binds to and activates ionotropic glutamate receptors. Administration of KA causes robust and recurrent seizures in the rat, and produces permanent damage in the CNS, specifically in the limbic system. Systemic injection of kainate results in both short-term and long-term effects on the rat central nervous system (CNS). The excitatory neuronal stimulation by kainate increases the expression of a variety of genes including immediate-early genes, growth factors, and opioid peptides. The short-term effects of kainate in the rat brain have been well characterized1–6. However, the long-term effects of kainate, especially on the opioid peptides, have not been reported.
KeywordsGranule Cell Dentate Gyrus Mossy Fiber Opioid Peptide Kainic Acid
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