Differential Regulation of APP Secretion by Apolipoprotein E3 and E4
Apolipoprotein E (apo E) is a cholesterol transport protein that is present both in blood as well as in central nervous system, where its levels increase following nerve injury. Presumably the function of apo E is to facilitates lipid uptake1. In the periphery, apo E is synthesized by the liver and taken up throughout the body via low density lipoprotein receptors1. In the central nervous system, apo E is synthesized by astrocytes and microglial cells following nerve injury1. Apo E avidly binds lipids, in particular cholesterol, and it is taken up by the axon during regeneration2. Thus, the action of apo E plays an important role in the ability of the brain to cope with neuronal injury. This role may also be critical in the ability of the brain to cope with a neurodegenerative illness, such as Alzheimer’s disease.
KeywordsPC12 Cell Neurite Outgrowth Amyloid Precursor Protein Neurite Extension Follow Nerve Injury
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