Lymphocyte Amyloid Precursor Protein mRNA Isoforms in Normal Aging and Alzheimer’s Disease
The amyloid precursor protein (APP) molecule is expressed on the surface of most cells including neurons.1 The three major isoforms of APP in brain contain 770, 751 and 695 amino acids, respectively. The two longer forms of the molecule contain a Kunitz-type serine protease inhibitor domain (KPI). These longer isoforms (APP770 and APP751) are the principal species found in non-neuronal cells whereas the shorter APP695 is the major form in differentiated neurons.2 Isoform changes have also been observed in AD and following astrocyte, glial and microglial, cell activation.3 It is still unknown which isoforms of APP and which cell types contribute to β/A4 peptide deposition in AD although a number of different cell types are potential contributors to the amyloid load.
KeywordsAmyloid Precursor Protein Normal Aging Amyloid Precursor Protein Gene Amyloid Load Amyloid Precursor Protein Level
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