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Eicosanoids pp 165–182Cite as

Leukotriene Antagonists and Synthetase Inhibitors; Clinical Applications in the Treatment of Bronchial Asthma

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Part of the book series: NATO ASI Series ((NSSA,volume 283))

Abstract

Asthma is a complex disease with the following characteristics: (1) airway obstruction that is reversible (but not completely so in some patients) either spontaneously or with treatment; (2) airway inflammation; and (3) increased airway responsiveness to a variety of stimuli (National Heart, Lung, and Blood Institute; National Asthma Education Program; Guidelines for the diagnostic and management of asthma, March 11, 1991). Recent observations in both human subjects and animal models suggest that the abnormalities of asthma are manifestations of airway inflammation that is a key factor even in patients with asthma at a clinically early stage (Laitinen et al., 1993).

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References

  • Adelroth, E., Morris, M.M., Hargreave, F.E., O’Byrne, P.M., 1986, Airway responsiveness to LTC4 and D4 and to methacholine in patients with asthma and normal controls, N. Engl. J. Med. 315:480–484.

    Article  PubMed  CAS  Google Scholar 

  • Augstein, J., Farmer, J.B., Lee, T.B., Sheard, P., Tattersall, M.L., 1973, Selective inhibitor of slow reacting substance of anaphylaxis, Nature [New Biol.] 245:215–217.

    Article  CAS  Google Scholar 

  • Barnes, N.C., Evans, J., Zarkzewski, J.T., Piper, P.J., Costello, J.F., 1989, A critical evaluation of the clinical rilevance of leukotrienes in bronchial asthma, Agents Actions Suppl. 28:123–133.

    CAS  Google Scholar 

  • Barnes, P., 1987, Neuropeptides in the lung: localization, function and pathophysiologic implications, J. Allergy Clin. Immunol. 79:285–295.

    Article  PubMed  CAS  Google Scholar 

  • Batt, D.G., 1992, 5-lipoxygenase inhibitors adn their anti-inflammatory activities, in Progress in Medicinal Chemistry, G.P. Ellis, D.K. Luscombe eds., Elsevier Science Publishers B.V., vol. 29 pp 1–63.

    Google Scholar 

  • Bisgaard, H., Groth, S., Madsen, F., 1985, Bronchial hyperreactivity to leukotriene D4 and histamine in exogenous asthma, Br. Med. J. 290:1468–1471.

    Article  CAS  Google Scholar 

  • Bisgaard, H., Kristensen, J., Sondergaard, J., 1982, The effect of leukotriene C4 and D4 on cutaneous blood flow in humans, Prostaglandins 23:797–801.

    PubMed  CAS  Google Scholar 

  • Bisgaard, H., Poulson, L., Sondergaard, I., 1987, Nebulisation and selective deposition of LTD4 in human lungs, Allergy 42:336–342.

    Article  PubMed  CAS  Google Scholar 

  • Borgeat, P., Samuelsson, B., 1979, Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids, Proc. Natl. Acad. Sci. U.S.A. 76: 3213–3217.

    Article  PubMed  CAS  Google Scholar 

  • Botto, A., DeLepeleire, I., Rochette, F., Reiss, T.F., Zhang, J., Kundu, S., Decramer, M., 1994, MK-0476 causes prolonged, potent, LTD4 receptor antagonism in the airways of asthmatics, Am. J. Resp. Crit. Care Med. 149:A465.

    Google Scholar 

  • Buckner, C.K., Krell, R.D., Laravuso, R.B., Coursin, D.B., Bernstein, P.R., Will, J.A., 1986, Pharmacological evidence that human intralobar airways do not contain different receptors that mediate contractions to leukotriene C4 and leukotriene D4, J. Pharmacol. Exp. Ther. 237:558–562.

    PubMed  CAS  Google Scholar 

  • Camp, R.D.R., Greaves, M.W., 1987, Inflammatory mediators in skin, Br. Med. Bull. 43:401–414.

    PubMed  CAS  Google Scholar 

  • Carry, M., Korley, V., Willerson, J.T., Weigelt, L., Ford-Hutchinson, A.W., Tagari, P., 1992, Increased urinary excretion in patients with cardiac ischemia. In vivo evidence for 5-lipoxygenase activation, Circulation 85:230–236.

    CAS  Google Scholar 

  • Carter, G.W., Young, P.R., Albert, D.H., Bouska, J., Dyer, R., Bell, R.L., Summers, J.D., Brooks, D.W., 1991, 5-lipoxygenase inhibitory activity of Zileuton, J. Pharmacol. Exp. Ther. 256:929–937.

    PubMed  CAS  Google Scholar 

  • Christie, P.E., Smith, C.M., Lee, T.H., 1991b, The potent and selective sulfidopeptide leukotriene antagonist, SK&F 104353, inhibits aspirin-induced asthma, Am. Rev. Respir. Dis. 144:957–958.

    Article  PubMed  CAS  Google Scholar 

  • Christie, P.E., Spur, B.W., Lee, T.H., 1991a, The effect of inhalation of the leukotriene receptor antagonist, SK&F 104353, on leukotriene C4-and leukotriene E4-induced bronchoconstriction in subjects with asthma, J. Allergy Clin. Immunol. 88:193–198.

    Article  PubMed  CAS  Google Scholar 

  • Cockcroft, D.W., Ruffin, R.E., Dolovich, J., Hargreave, F.E., 1977, Allergen-induced increase in non-allergic bronchial reactivity, Clin. Allergy 7:503–513.

    Article  PubMed  CAS  Google Scholar 

  • Coles, S.J., Neill, K.H., Reid, L.M., et al., 1983, Effects of leukotriene C4 and D4 on glycoprotein and lysozyme secretion by human bronchial mucosa, Prostaglandins 25:155–170.

    PubMed  CAS  Google Scholar 

  • Cunningham, F., 1990, Lipid mediators in inflammatory skin disorders, J. Lipid Mediators 2:61–74

    CAS  Google Scholar 

  • Cuss, F.M., Dixon, C.M., Barnes, P.J., 1986, Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man, Lancet 2:189–192.

    Article  PubMed  CAS  Google Scholar 

  • Dahlén, B., Margolskee, D.J., Zetterström, O., Dahlén, S.-E., Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects, Thorax 48:1205-1210.

    Google Scholar 

  • Dahlén, B., Zetterström, O., Björck, T., Dahlén, S.-E., 1994, The leukotriene-antagonist ICI 204,219 inhibits the early airway reaction to cumulative bronchial challenge with allergen in atopic asthmatics, Eur. Respir. J. 7:324–331.

    Article  PubMed  Google Scholar 

  • Dahlén, S.E., Hedqvist, P., Hammarström, S., Samuelsson, B., 1980, Leukotrienes are potent constrictor of human bronchi, Nature 228:484–486.

    Article  Google Scholar 

  • Davidson, A.B., Lee, T.H., Scanion, P.D., Solway, J., McFadden, E.R. jr, Ingram, R.H. jr, Corey, E.J., Austen, K.F., Drazen, J.M., 1987, Bronchocostrictor effects of leukotriene E4 in normal and asthmatic subjects, Am. Rev. Respir. Dis. 135:333–337.

    PubMed  CAS  Google Scholar 

  • Dennis, E.A., Ackermann, E.J., Deems, R.A., Reynolds, L.J., 1995, Multiple forms of PLA2 in macrophages capable of arachidonic acid release for eicosanoid biosynthesis, in Advances in Prostaglandin, Thromboxane, and Leukotriene Research, B. Samuelsson, P.W. Ramwell, R. Paoletti, G.C. Folco, E. Granström and S. Nicosia eds., Raven Press, New York, vol. 23 pp. 75–80.

    Google Scholar 

  • Dixon, R.A.F., Diehl, R.E., Opas, E., Rands, E., Vickers, P.J., Evans, J.F., Gillard, J.W., Miller, D.K., 1990, Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis, Nature 343:282–284.

    Article  PubMed  CAS  Google Scholar 

  • Drazen, J.M., Austen, K.F, 1987, Leukotrienes and airway responses, Am. Rev. Respir. Dis. 136:985–998.

    Article  PubMed  CAS  Google Scholar 

  • Dugas, B., Paul-Eugene, N., Cairns, J., Gordon, J., Calenda, A., Mencia-Huerta, J.M., Braquet, P., 1990, Leukotriene B4 potentiates the expression and release of FCεRII/CD23, and proliferation and differentiation of human B lynfocytes induced by IL-4, J. Immunol. 145:3406.

    PubMed  CAS  Google Scholar 

  • Dutoit, J.I., Salome, C.M., Woolcock, A.J., 1987, Inhaled corticosteroids reduce the severity of bronchial hyperresponsiveness in asthma but oral theophylline does not, Am. Rev. Respir. Dis. 136:1174–1178.

    Article  PubMed  CAS  Google Scholar 

  • Ellis, J.L., Undem, B.J., 1994, Role of cysteinyl-leukotrienes and histamine in mediating intrinsic tone in isolated human bronchi, Am. J. Respir. Crit. Care Med. 149:118–122.

    Article  PubMed  CAS  Google Scholar 

  • Empey, D.W., Laitinen, L.A., Jacobs, L., Gold, W.M., Nadel, J. A., 1976, Mechanism of bronchial hyperreactivity in normal subjects following upper respiratory tract infection, Am. Rev. Respir. Dis. 113:131–139.

    PubMed  CAS  Google Scholar 

  • Feinmark, S.J., Cannon, P.J., 1986, Endothelial cell leukotriene C4 synthesis results from intracellular trasfer of leukotriene A4synthetized by polymrphonuclear leukocytes, J. Biol. Chem. 261: 16466–16472.

    PubMed  CAS  Google Scholar 

  • Findlay, S.R., Barden, J.M., Easley, C.B., Glass, M., 1992, Effect of the oral leukotriene antagonist, ICI 204,219, on antigen-induced bronchoconstriction in subjects with asthma, J. Allergy Clin. Immunol., 89:1040–1045.

    Article  PubMed  CAS  Google Scholar 

  • Fitzpatrick, F., Liggett, W., McGee, J., Bunting, S., Morton, D., Samuelsson, B., 1984, Metabolism of leukotriene A4 by human erytrocytes, J. Biol. Chem. 259:11403–11407.

    PubMed  CAS  Google Scholar 

  • Fitzsimmons, B.J., Rokach, J., 1989, in Leukotrienes and Lipoxygenases, J. Rokach ed., Elsevier, Amsterdam, pp. 427–502.

    Google Scholar 

  • Ford-Hutchinson, A.W., 1990, Regulation of the production and action of leukotrienes by MK-571 and MK-886, in Advances in Prostaglandin, Thromboxane, and Leukotriene Research, B. Samuelsson, P.W. Ramwell, R. Paoletti, G.C. Folco, E. Granström eds., Raven Press, New York, vol. 21 App. 9–16.

    Google Scholar 

  • Ford-Hutchinson, A.W., Bray, W.M., Doig, M.V., Shipley, M.E., Smith, M.J.H., 1980, Leukotriene B, a potent chemokinetic and aggregating substance released from PMN leukocytes, Nature 286:264–265.

    Article  PubMed  CAS  Google Scholar 

  • Fruchtmann, R., Mohrs, K.-H., Hatzelmann, A., Raddatz, S., Fugmann, B., Junge, B., Horstmann, H., Müller-Peddinghaus, R., 1993, In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis, Agents Actions 38:188–195.

    Article  PubMed  CAS  Google Scholar 

  • Gaddy J.N., Margolskee, D.J., Bush, R.K., Williams, V.C., Busse, W.W., 1992, Bronchodilation with a potent and selective leukotriene D4 (LTD4) receptor antagonist (MK-571) in patients with asthma, Am. Rev. Respir. Dis. 146:358–363.

    Article  PubMed  CAS  Google Scholar 

  • Goetzl, E.J., Pickett, W.C., 1980, The human PMN leukocyte chemotactic activity of complex hydroxy-eicosatetraenoic acids (HETEs), J. Immunol. 125:1789.

    PubMed  CAS  Google Scholar 

  • Golden, J.A., Nadel, J.A., Boushey, H.A., 1978, Bronchial hyperirritability in healty subjects after exposure to ozone, Am. Rev. Respir. Dis 118:287–294.

    PubMed  CAS  Google Scholar 

  • Hannah, C.J., Bach, M.K., Pare, P.D. et al., 1981, Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro, Nature 290:343–344.

    Article  Google Scholar 

  • Hardy, C.C., Robinson, C., Tattersfield, A.E., Holgate, S.T., 1984, The bronchocostrictor effect of inhaled prostaglandin D2 in normal and asthmatic men, N. Engl. J. Med. 311:209–213.

    Article  PubMed  CAS  Google Scholar 

  • Hargreave, F.E., Ryan, G., Thomson, N.C., et al., 1981, Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance, J. Allergy Clin. Immunol. 68:347–355.

    Article  PubMed  CAS  Google Scholar 

  • Hatzelmann, A., Goossens, J., Fruchtmann, R., Mohrs, K.-H., Raddatz, S., Müller-Peddinghaus, R., 1994, Inversely-correlated inhibition of human 5-lipoxy genase activity by BAY X1500 and other quinoline derivates in intact cells and a cell-free system-Implications for the function of 5-lipoxygenase activating protein, Biochem. Pharmacol. 47(n°12):2259–2268.

    Article  PubMed  CAS  Google Scholar 

  • Holroyde, M.C., Altounyan, R.E.C., Cole, M., Dixon, M., Elliot, E.V., 1981, Bronchocostriction produced in man by leukotrienes C and D, Lancet 2: 17–18.

    Article  PubMed  CAS  Google Scholar 

  • Hui, K.P., Taylor, I.K., Taylor, G.W, Rubin, P., Kesterson, J., Barnes, N.C., Barnes, P.J., 1991, Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after challenge in asthmatic patients, Thorax 46:184–189.

    Article  PubMed  CAS  Google Scholar 

  • Israel, E., Dermarkarian, R., Rosemberg, M., Sperling, R., Taylor, G., Rubin, P., Drazen, J.M., 1990, The effect of a 5-lipoxigenase inhibitor on asthma induced by cold, dry air, N. Engl. J. Med. 323:1740–1744.

    Article  PubMed  CAS  Google Scholar 

  • Israel, E., Fischer, A.R., Rosemberg, M.A., Lilly, CM., Callery, J.C., Shapiro, J., Cohn, J., Rubin, P., Drazen, J.M., 1993a, The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin, Am. Rev. Respir. Dis. 148:1447–1451.

    Article  PubMed  CAS  Google Scholar 

  • Israel, E., Rubin, P., Kemp, J.P., Grossman, J., Pierson, W., Siegel, S.C., Tinkelman, D., Murray, J.J., Busse, W., Segal, A.T., Fish, J., Kaiser, H.B., Ledford, D., Wenzel, S., Rosenthal, R., Cohn, J., Lanni, C., Pearlman, H., Karahalios, P., Drazen, J.M., 1993b, The effect of inhibition of 5-lipoxygenase by Zileuton in mild-to-moderate asthma, Ann. Intern. Med. 119:1059–1066.

    Article  PubMed  CAS  Google Scholar 

  • Jones, T.R., Champion, E., Charette, L., Ford-Hutchinson, A.W., Labelle, M., Leblanc, Y., Lord, A., Masson, P., McAuliffe, M., McFerlane, C.S., Metters, K.M., Ouimet, N., Pickett, C., Piechuta, H., Rochette, C., Rodger, I.W., Sawyer, N., Wiang, Y.B., Young, R.N., Zamboni, R., 1994, Pharmacology of MK-0476, a potent and selective leukotriene D4-receptor antagonist, Am. J. Resp. Crit. Care Med. 149:A463.

    Google Scholar 

  • Jones, T.R., Davis, C., Daniel, E.E., 1982, Pharmacological study of the contractile activity of leukotriene C4 and D4 on isolated human airway smooth muscle, Can. J. Physiol. Pharmacol. 60:638–643.

    Article  PubMed  CAS  Google Scholar 

  • Kennedy, N.P., Keeling, P.W.N., 1987, Review: lipoxygenase inhibitors and the gut, Aliment. Pharmacol. Ther. 1:263–272.

    Article  PubMed  CAS  Google Scholar 

  • Kips, J.G., Joos, G.F., De Lepeleire, I., Margolskee, D.J., Buntinx, A., Pauwels, R.A., Van der Straeten, M.E., 1991, MK-571, a potent antagonist of leukotriene D4-induced bronchoconstriction in the human, Am. Rev. Respir. Dis. 144:617–621.

    Article  PubMed  CAS  Google Scholar 

  • Kohno, S., Tsuzuike, N., Yamamura, H., Nabe, T., Horiba, M., Ohata, K., 1993, Important role of peptido leukotrienes (p-LTs) in the resting tonus of isolated human bronchi, Japan. J. Pharmacol. 62:351–355.

    Article  CAS  Google Scholar 

  • Krell, R.D., Aharony, D., Buckner, C.K., Keith, R.A., Kusner, E.J., Snyder, D.W., Bernstein, P.R., Matassa, V.G., Yee, Y.K., Brown, F.J., Hesp, B., Giles, R.E., 1990, The preclinical pharmacology of ICI 204, 219. A peptide luekotriene antagonist, Am. Rev. Respir. Dis. 141:978–987.

    Article  PubMed  CAS  Google Scholar 

  • Laitinen, L.A., Laitinen, A., Haahtela, T., 1993, Airway mucosal inflammation even in patients with newly diagnosed asthma, Am. Rev. Respir. Dis. 147:697–704.

    Article  PubMed  CAS  Google Scholar 

  • Lammers, J.-W.J., Van Daele, P., Van den Elshout, F.M.J., Decramer, M., Buntinx, A., De Lepeleire, I., Friedman B., 1992, Brochodilator properties of an inhaled leukotriene D4 antagonist (Verlukast—MK-0679) in asthmatic patients, Pulm. Pharmacol. 5:121–125.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, R.A., Austen, K.F., 1984, TheBiologically active leukotrienes. Biosynthesis, metabolism, receptors, functions, and pharmacology, J. Clin. Invest. 73:889–897.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, R.A., Austen, K.F., Soberman, R.J., 1990, Leukotrienes and other products of the 5-lipoxygenase pathway-Biochemistry and relation to pathobiologi in human diseases, N. Engl. J. Med. 323:645–655

    Article  PubMed  CAS  Google Scholar 

  • Lewis, R.A., Robin, J.L., 1985, Arachidonic acid derivatives as mediators of asthma, J. Allergy Clin. Immunol. 76:259–264.

    Article  PubMed  CAS  Google Scholar 

  • Maclouf, J., Murphy, R.C., Henson, P., 1989, Transcellular sulfidopeptide leukotriene biosynthetic capacity of vascular cells, Blood 74:703–707.

    PubMed  CAS  Google Scholar 

  • Makker, H.K., Lau, L.C., Thomson, H.W., Binks, S.M., Holgate, S.T., 1993, The protective effect of inhaled leukotriene D4 receptor antagonist ICI 204,219 against exercise-induced asthma, Am. Rev. Respir. Dis. 147:1413–1418.

    Article  PubMed  CAS  Google Scholar 

  • Manning, P.J., Watson, R.M., Margolskee, D.J., Williams, V.C., Schwartz, J.I., O’Byrne, P.M., 1990, Inhibition of exercise-induced bronchoconstriction by MK-571, a potent leukotriene D4-receptor antagonist, N. Engl. J. Med. 323:1736–1739.

    Article  PubMed  CAS  Google Scholar 

  • Mapp, C.E., Di Giacomo, G.R., Omini, C., Broseghini, C., Fabbri, L.M., 1986, Late, but non early, asthmatic reactions induced by toluene-diisocyanate are associated with increased airway responsiveness to methacholine, Eur. J. Respir. Dis. 69:276–284.

    PubMed  CAS  Google Scholar 

  • Margolskee, D.J., 1991, Clinical experience with MK-571. A potent and specific LTD4 receptor antagonist, Ann. N.Y. Acad. Sci. 629:148–156.

    Article  PubMed  CAS  Google Scholar 

  • Maron, Z., Shelhamer, J.H., Bach, M.K., et al., 1982, Slow reacting substances LTC4 and D4 increase the release of mucus from human airways in vitro, Am. Rev. Respir. Dis. 126: 449–451.

    Google Scholar 

  • Müller-Peddinghaus, R., Kohlsdorfer, C., Theisen-Popp, P., Fruchtmann, R., Perzborn, E., Beckermann, B., Bühner, K., Ahr, H.-J., Mohrs, K.-H., 1993 BAY X1500, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics, J. Pharmacol. Exp. Ther. 267:51–57

    PubMed  Google Scholar 

  • Murphy, R.C., Hammarström, S., Samuelsson, B., 1979, Leukotriene C: a slow-reacting substance from murine mastocytoma cells, Proc. Natl. Acad. Sci. U.S.A. 76:4275–4279.

    Article  PubMed  CAS  Google Scholar 

  • Nasser, S.M.S., Bell, G.S., Foster, S., Spruce, K.E., MacMillan R., Williams, A.J., Lee, T.H., Arm, J.P., 1994b, Effect of the 5-lipoxygenase inhibitor ZD 2138 on aspirin-induced asthma, Thorax 49:749–756.

    Article  PubMed  CAS  Google Scholar 

  • Nasser, S.M.S., Bell, G.S., Hawksworth, R.J., Spruce, K.E., MacMillan R., Williams, A.J., Lee, T.H., Arm, J.P., 1994a, Effect of the 5-lipoxygenase inhibitor ZD 2138 on allergen-induced early and late asthmatic responses, Thorax 49:743–748.

    Article  PubMed  CAS  Google Scholar 

  • Nathan, R.A., Glass, M., Minkwitz, M.C., 1994, Inhaled ICI 204,219 blocks antigen-induced bronchoconstriction in subjects with bronchial asthma, Chest 105:483–488.

    Article  PubMed  CAS  Google Scholar 

  • O’Shaughnessy, K.M., Taylor, I.K., O’Connor, B., O’Connell, F., Thomson, H., Dollery, C.T., 1993, Potent leukotriene D4 receptor antagonist ICI 204, 219 given by the inhaled route inhibits the early but not the late phase of allergen-induced bronchoconstriction, Am. Rev. Respir. Dis. 147:1431–1435.

    Article  PubMed  Google Scholar 

  • Orning, L., Hammarström, S., Samuelsson, B., 1980, Leukotriene D4: a slow reacting substance from rat basophilic leukemia cells, Proc. Natl. Acad. Sci. U.S.A. 77:2014–2017.

    Article  PubMed  CAS  Google Scholar 

  • Osborn, R.R., Hay, D.W.P., Wasserman, M.A., Torphy T. J., 1992, SK&F 104353, a selective leukotriene receptor antagonist, inhibits LTD4-and antigen-induced bronchoconstriction in cynomolgus monkeys, Pulm. Pharmacol. 5(3): 153–157.

    Article  PubMed  CAS  Google Scholar 

  • Piacentini, G.L., Kaliner, M.A., 1991, The potential roles of leukotrienes in bronchial asthma, Am. Rev. Respir. Dis. 143:S96–S99.

    Article  PubMed  CAS  Google Scholar 

  • Pierson, W.E., LaForce, C.F., Bell, T.D., MacCosbe, P.E., Sykes, R.S., Tinkelman, D., 1990, Long-term, double-blind comparison of controlled-release albuterol versus sustained-release theophylline in adolescents and adults with asthma, J. Allergy Clin. Immunol. 85:618–626.

    Article  PubMed  CAS  Google Scholar 

  • Platts-Mills, T.A.E., Mitchell, E.B., Nock, P., Tovey, E.R., Moszoro, H., Wilkins, S.R., 1982, Reduction of bronchial hyperreactivity during prolonged allergen avoidance, Lancet 2:675–678.

    Article  PubMed  CAS  Google Scholar 

  • Rådmark, O., Zhang, Y.-Y., Hammarberg, T., Lind, B., Hamberg, M., Brungs, M., Steinhilber, D., Samuelsson, B., 1995, 5-Lipoxygenase: structure and stability of recombinant enzyme, regulation in Mono Mac 6 cells, in Advances in Prostaglandin, Thromboxane, and Leukotriene Research, B. Samuelsson, P.W. Ramwell, R. Paoletti, G.C. Folco, E. Granström and S. Nicosia eds., Raven Press, New York, vol. 23 pp. 1–9.

    Google Scholar 

  • Raud, J., Dahlén, S.E., Sydbom, A., Lindbom, L., Hedqvist, P., 1988, Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E2: apparent correlation with in vivo modulation of mediator release, Proc. Natl. Acad. Sci. U.S.A. 85:2315–2319.

    Article  PubMed  CAS  Google Scholar 

  • Robuschi, M., Riva, E., Fuccella, L.M., Vida, E., Barnabe, R., Rossi, M., Gambaro, G., Spagnotto, S., Bianco, S., 1992, Prevention of exercise-induced bronchoconstristion by a new leukotriene antagonist (SK&F 104353), Am. Rev. Respir. Dis. 145:1285–1288.

    Article  PubMed  CAS  Google Scholar 

  • Rola-Pleszczynski, M., Borgeat, P., Sirois, P., 1982, Leukotriene B4 induces human suppressor lymphocytes, Biochem. Biophys. Res. Commun. 108:1531–1537.

    Article  PubMed  CAS  Google Scholar 

  • Sala, A., Rossoni, G., Buccellati, C., Berti, F., Folco, G.C., Maclouf, J., 1993, Formation of sulfidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit, Br. J. Pharmacol. 110:1206–1212.

    Article  PubMed  CAS  Google Scholar 

  • Sala, A., Voelkel, N., Maclouf, J., Murphy, R.C., 1990, Leukotriene E4 elimination and metabolism in normal human subjects, J. Biol. Chem. 265(35):21771–21778.

    PubMed  CAS  Google Scholar 

  • Samuelsson, B., Rouzer, C.A., Matsumoto, T., 1987, Human leukocyte 5-lipoxygenase: an enzyme possessing dual enzymatic activities and a multicomponent regulatory system, in Advances in Prostaglandin, Thromboxane, and Leukotriene Research, B. Samuelsson, R. Paoletti, P.W. Ramwell eds., Raven Press, New York, vol. 17A pp.1–11.

    Google Scholar 

  • Sheppard, D., Wong, W.S., Uehora, C.F., Nadel J.A., Boushey, H.A., 1980, Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide, Am. Rev. Respir. Dis. 122:873–878.

    PubMed  CAS  Google Scholar 

  • Smith, L.J., Geller, S., Ebright, L., Glass, M., Thyrum, P.T., 1990, Inhibition of leukotriene D4-induced bronchoconstriction in normal subjects by the oral LTD4 receptor antagonist ICI 204,219, Am. Rev. Respir. Dis. 141:988–992.

    Article  PubMed  CAS  Google Scholar 

  • Smith, L.J., Greenberger, P.A., Patterson, R., Krell, R.D., Bernstein P.R., 1985, The effect of inhaled leukotriene D4 in humans, Am. Rev. Respir. Dis. 131:368–372.

    PubMed  CAS  Google Scholar 

  • Smith, M.J.H., Ford-Hutchinson, A.W., Bray, M.A., 1980, Leukotriene B: a potential mediator of inflammation, J. Pharm. Pharmacol. 32:517.

    Article  PubMed  CAS  Google Scholar 

  • Snyder, D.W., Krell, R.D., 1984, Pharmacological evidence for a distinct leukotriene C4 receptor in guinea-pig trachea, J. Pharmacol. Exp. Ther. 231:616–622.

    PubMed  CAS  Google Scholar 

  • Spector, S.L., Smith, L.J., Glass, M., and ACCOLATE-Asthma Trialists Group, 1994, Effects of 6 weeks of therapy with oral doses of ICI 204, 219, a leukotriene D4 receptor antagonist, in subjects with bronchial asthma, Am. J. Respir. Crit. Care Med. 150:618–623.

    Article  PubMed  CAS  Google Scholar 

  • Staerk Laursen, L., Naesdal, J., Bukhave, K., Lauritsen, K., Rask-Madsen, J., 1990, Selective 5-lipoxygenase inhibition in ulcerative colitis, Lancet 335:683–685.

    Article  Google Scholar 

  • Szczeklik, A., 1994, Aspirin-induced asthma: an update and novel findings, in Advances in Prostaglandin, Thromboxane, and Leukotriene Research, S.E. Dahlén, P. Hedqvist, B. Samuelsson, W.A. Taylor, J. Fritsch eds., Raven Press, New York, vol. 22 pp. 185–198.

    Google Scholar 

  • Taylor, I.K., O’Shaughnessy, K.M., Fuller, R.W., Dollery, C.T., 1991, Effect of cysteinyl-leukotriene receptor antagonist ICI 204, 219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects, Lancet 337:690–694.

    Article  PubMed  CAS  Google Scholar 

  • Torphy, T.J., Faiferman, I., Gleason, J.G., Hall, R.F., Lewis, M.A., Broom, C., Helfrich, H.M., Newton, J.F., Hay, D.W.P., 1991, The preclinical and clinical pharmacology of SK&F 104353, a potent and selective peptidoleukotriene receptor antagonist, Ann. N.Y. Acad. Sci. 629:157–167

    Article  PubMed  CAS  Google Scholar 

  • Torphy, T.J., Newton, J.F., Wasserman, M.A., Vickery-Clark, L., Osborn, R.R., Bailey, L.S., Yodis, L.A.R, Underwood, D.C., Hay, D.W.R, 1989, The bronchopulmunary pharmacology of Sk&F 104353 in anesthetized guinea pigs: demostration of potent and selective antagonism of responses to peptidoleukotrienes, J. Pharmacol. Exp. Ther. 249:430–437.

    PubMed  CAS  Google Scholar 

  • Vathenen, A.S., Knox, A.J., Wisniewski, A., Tattersfield, A.E., 1991, Time course of change in bronchial reactivity with an inhaled corticosteroid in asthma, Am. Rev. Respir. Dis. 143:1317–1321.

    Article  PubMed  CAS  Google Scholar 

  • Wahedna, I., Wisniewski, A.S., Tattersfield, A.E., 1991, Effect of Rg 12525, an oral leukotriene D4 antagonist, on the airway response to inhaled leukotriene D4 in subjects with mild asthma, Br. J. Clin. Pharmac. 32:512–515.

    Article  CAS  Google Scholar 

  • Wanner, A., Sielczak, M., Mella, J.F., et al., 1986, Ciliary responsiveness in allergic and non-allergic airways, J. Appl. Physiol. 60:1967–1971.

    PubMed  CAS  Google Scholar 

  • Weiss, J.W., Drazen, J.M., McFadden, E.R. jr. et al., 1983, Airway constriction in normal humans produced by inhalation of leukotriene D, JAMA 249:2814–2817.

    Article  PubMed  CAS  Google Scholar 

  • Wetterholm, A., Macchia, L., Haeggstrom, J.Z., 1995, Metal inhibition of LTA4 hydrolase and cellular 5-lipoxygenase activity, in Advances in Prostaglandin, Thromboxane, and Leukotriene Research, B. Samuelsson, P.W. Ramwell, R. Paoletti, G.C. Folco, E. Granström and S. Nicosia eds., Raven Press, New York, vol. 23 pp. 179–181.

    Google Scholar 

  • Yamaguchi, T., Kohrogi, H., Honda, I., Kawano, O., Sugimoto, M., Araki, S., Ando, M., 1992, A novel leukotriene antagonist, ONO-1078, inhibits and reverses human bronchial contraction induced by leukotrienes C4 and D4 and antigen in vitro, Am. Rev. Respir. Dis. 146:923–929.

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto, H., Nagata, M., Kuramitsu, K., Tabe, K., Kiuchi, H., Sakamoto, Y., Yamamoto, K., Dohi, Y., 1994, Inhibition of analgesic-induced asthma by leukotriene receptor antagonist ONO-1078, Am. J. Respir. Crit. Care Med. 150:254–257.

    Article  PubMed  CAS  Google Scholar 

  • Yamaoka, K.A., Claésson, H.-E., Rosén, A., 1989, Leukotriene B4 enhances activation, proliferation, and differentiation of human B lynfocytes, J. Immunol. 143:1996–2000.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Center for Cardiopulmonary Pharmacology, Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy

    G. C. Folco, C. Buccellati, T. Testa, M. Bolla & A. Sala

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  1. G. C. Folco
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  2. C. Buccellati
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  3. T. Testa
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  4. M. Bolla
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  5. A. Sala
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Editors and Affiliations

  1. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    Gian Carlo Folco

  2. Karolinska Institute, Stockholm, Sweden

    Bengt Samuelsson

  3. Hôpital Lariboisére, Paris, France

    Jacques Maclouf

  4. University of Verona Medical School, Verona, Italy

    G. P. Velo

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Folco, G.C., Buccellati, C., Testa, T., Bolla, M., Sala, A. (1996). Leukotriene Antagonists and Synthetase Inhibitors; Clinical Applications in the Treatment of Bronchial Asthma. In: Folco, G.C., Samuelsson, B., Maclouf, J., Velo, G.P. (eds) Eicosanoids. NATO ASI Series, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0200-9_16

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  • DOI: https://doi.org/10.1007/978-1-4899-0200-9_16

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