Microvascular Actions and Interactions of Eicosanoids and Histamine in Inflammation
The microvascular system has a key role in the expression of inflammatory reactions to allergens and other noxious stimuli. Inflammation in its acute phase is characterized by three partly overlapping reactions; increased blood flow, extravasation of plasma, and recruitment of circulating leukocytes. Even though the outlines of early inflammation are thus well-known and predictable, it is not a matter of a static phenomenon but of an instrument in continuous motion, played upon by various mediators, modulators, and feedback mechanisms. In order to follow the facets of this dynamic process, direct inspection of the microvascular bed is required, as can be achieved with intravital microscopy. With the development of quantitative measuring techniques (cf. Raud and Lindbom 1994) this methodology has proven most useful in elucidating the complex interplay between tissue cells, components of the blood, and the venular endothelium, which all together form the basis of the inflammatory process.
KeywordsAllergic Inflammation Intravital Microscopy Cheek Pouch Plasma Extravasation Plasma Leakage
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