Eicosanoids pp 127-136 | Cite as

Receptors and Second Messengers for Cys-Leukotrienes

  • S. Nicosia
  • V. Capra
  • M. R. Accomazzo
  • E. Galbiati
  • D. Ragnini
  • R. Saponara
  • S. Novarini
  • G. E. Rovati
Part of the NATO ASI Series book series (NSSA, volume 283)


It is well known that leukotrienes (LTs) can be divided into two classes, which differ for both the chemical structure and the pattern of biological activities: one class encompasses LTB4 only, an hydroxyacid that, mainly by means of its chemotactic action, plays a fundamental role in inflammation. The second class comprises LTC4, LTD4 and LTE4, cysteine containing leukotrienes (Cys-LTs), which can be interconverted into one another. They are potent smooth muscle constrictors, cause mucus hypersecretion in the airways and contribute to the onset of inflammation by their ability to cause plasma extravasation. Given these differences, it is not unexpected that, although both classes have been demonstrated to elicit their actions through the interaction with specific receptors, the receptors for LTB4 are totally different from those for Cys-LTs and no cross-reactivity has been shown among the two classes.


Human Airway Mucus Hypersecretion Human Bronchus Methane Sulfonamide Sheep Lung 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • S. Nicosia
    • 1
  • V. Capra
    • 1
  • M. R. Accomazzo
    • 1
  • E. Galbiati
    • 1
  • D. Ragnini
    • 1
  • R. Saponara
    • 1
  • S. Novarini
    • 1
  • G. E. Rovati
    • 1
  1. 1.Institute of Pharmacological SciencesUniversity of MilanMilanItaly

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