Abstract
The biological reactivity of copper is the basis for both its essentiality and toxicity. Prior to the advent of modern medicine, drug design, and therapeutics, there is a long historical documentation of the use of copper salts in ointments for over 2000 years. The biological activity of copper was unknown at the time but was used for a wide variety of maladies including diseases of the skin, various infections, and recoveries from neurological disorders (Deuschle and Weser, 1985). Toxic properties of copper were also recognized as copper sulfate was used as a murder weapon and a suicidal agent.
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Prohaska, J.R. (1997). Neurochemical Roles of Copper as Antioxidant or Prooxidant. In: Connor, J.R. (eds) Metals and Oxidative Damage in Neurological Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0197-2_4
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