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Metals and Oxidative Damage in Neurological Disorders pp 315–324Cite as

Tardive Dyskinesia and Oxidative Stress

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Abstract

The use of antipsychotic drugs is associated with a number of neurologic complications. Some of these complications occur after acute administration, while others occur after chronic use of the drugs (Table 16.1). The treatment of the acute side-effects often involves decreasing the amount of neuroleptics. When this is not possible because of the patients’ clinical status, the addition of anticholinergic drugs can provide significant relief to the patients. The treatment of the long-term complications of neuroleptics is more complicated. Thus, the purpose of this chapter is to touch briefly on the role of some therapeutic approaches to tardive dyskinesia and to elaborate on the idea that oxidative stress plays a role in the manifestations of this neurologic syndrome.

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  1. Molecular Neuropsychiatry Section, NIH/NIDA, Intramural Research Program, Baltimore, Maryland, 21224, USA

    Jean Lud Cadet

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  1. Pennsylvania State University, Hershey, Pennsylvania, USA

    James R. Connor

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Cadet, J.L. (1997). Tardive Dyskinesia and Oxidative Stress. In: Connor, J.R. (eds) Metals and Oxidative Damage in Neurological Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0197-2_16

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