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Iron and Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury Directions for Therapeutic Intervention

  • Charles Palmer

Abstract

When placental or pulmonary gas exchange is compromised in the fetus or newborn infant it produces hypoxemia, hypercapnia, and metabolic acidosis. Initially during asphyxia, blood flow to the brain increases to maintain cerebral energy metabolism until cardiac depression causes hypotension, bradycardia, and cerebral ischemia (Van-nucci, 1990). Unless prompt and effective resuscitation is achieved, the asphyxiated infant will die. Even when resuscitation is successful, survival may be accompanied by varying degrees of brain injury, the nature of which is related to the duration of the primary insult, the gestational age, and therapeutic interventions initiated during the post-resuscitation period.

Keywords

Nitric Oxide Nitric Oxide Brain Injury Cerebral Ischemia Middle Cerebral Artery Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Charles Palmer
    • 1
  1. 1.Division of Newborn Medicine, Department of Pediatrics, M. S. Hershey Medical CenterPennsylvania State University College of MedicineHersheyUSA

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