The Bilateral 6-Hydroxydopamine-Lesioned Marmoset Model of Parkinson’s Disease
Idiopathic Parkinson’s disease is a neurodegenerative disease of the dopaminergic neurons of the substantia nigra pars compacta. It is characterised by a triad of symptoms, bradykinesia, rigidity and resting tremor. Interspecies variation in the responses to treatment necesitates the use of primates in the development of novel approaches to the management of Parkinson’s disease. Several different primate models of Parkinson’s disease are commonly used, including the MPTP-treated macaque (Burns et al. 1983), the MPTP-treated marmoset (Brotchie et al. 1991; Close et al. 1990) and the unilateral 6-hydroxydopamine (6-OHDA)-lesioned marmoset (Annett et al. 1992). The MPTP-treated macaque is regarded as the ‘gold standard’ model as it accurately reproduces the pathology, symptoms and response to drug treatment seen in the idiopathic condition, including the development of levodopa-induced dyskinesias (Mitchell et al. 1989; Miller & Delong 1987; Bedard et al. 1986). However, poor availability and difficulty in breeding macaques limits their widespread usage. Problems with housing and handling are also encountered in using MPTP-treated macaques due to the large size of the animals.
KeywordsDopaminergic Neuron Parkinsonian Symptom Parkinsonian State Excitatory Amino Acid Transmission Marmoset Model
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