Experimental Approach to Akinesia

Successful Development of an Animal Model of Akinesia without Tremor and Rigidity
  • Hideto Miwa
  • Masayuki Yokochi
  • Tatsu Fuwa
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)


Since the development of levodopa therapy, the quality of daily life of patients with Parkinson’s disease (PD) has dramatically improved. However, after several years of levodopa therapy, in most cases, both the efficacy of the levodopa therapy and the level of the patients’ motoricity gradually decrease (Rinne, 1981; Narabayashi, 1993; Marsden and Fahn, 1981; Lieberman et al., 1972; Bonnet et al., 1987). Therefore, it is clinically relevant to investigate why the therapeutic effect of levodopa on akinesia is limited, and why the levodopa effect on akinesia differs from that on other symptoms such as rigidity and tremor. We have no satisfactory answers to these questions, since the exact pathophysiological mechanisms underlying parkinsonian symptoms have not been elucidated.


Lateral Hypothalamus Bilateral Lesion Spontaneous Movement Levodopa Therapy Medial Forebrain Bundle 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Hideto Miwa
    • 1
    • 2
  • Masayuki Yokochi
    • 1
  • Tatsu Fuwa
    • 1
  1. 1.Department of NeurologyTokyo Metropolitan Institute for NeuroscienceFuchu, Tokyo 183Japan
  2. 2.Department of NeurologyJuntendo University School of MedicineBunkyo-ku, Tokyo 113Japan

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