A Histochemical Study of Iron and Ferritin in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Induced Hemiparkinsonian Monkeys

  • Keigo Goto
  • Hideki Mochizuki
  • Hisamasa Imai
  • Haruhiko Akiyama
  • Yoshikuni Mizuno
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)


Iron is increased in the substantia nigra of patients with Parkinson’s disease (PD). The mechanism of its accumulation, however, remains to be explored. In this study, we stereotactically injected MPTP into the unilateral putamen or caudate nucleus of six monkeys. The substantia nigra and the basal ganglia regions were stained for iron and ferritin by histochemical methods. We found a marked increase in the intensity of iron staining in the pars compacta of the substantia nigra. On the other hand, no significant difference was noted between the injected side and the non-injected side in ferritin steining. Such results suggest that the iron accumulation in this model as well as in PD may be a result of nigral degeneration, but unbalanced increase in iron with respect to the amount of ferritin may contribute to the progression of the disease by inducing oxidative stress.


Tyrosine Hydroxylase Substantia Nigra Caudate Nucleus Iron Accumulation Iron Staining 


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Keigo Goto
    • 1
  • Hideki Mochizuki
    • 1
    • 2
  • Hisamasa Imai
    • 1
  • Haruhiko Akiyama
    • 2
  • Yoshikuni Mizuno
    • 1
  1. 1.Department of NeurologyJuntendo University School of MedicineBunkyo-ku, Tokyo 113Japan
  2. 2.Tokyo Institute of PsychiatrySetagaya-ku, Tokyo 159Japan

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