Single Unit Activity of the Human Globus Pallidus during Verbally Cueing Voluntary Movement
The activity of 513 units in external and internal segments of the human Globus Pallidus (GPe, GPi) analyzed during 24 stereotactic operations in parkinsonian patients made it possible to clarify the characteristics of the evoked activity of pallidal units during the performance of a verbally cueing motor tasks and to reveal the role of GP in the organization of voluntary movement in man.
Microelectrode recordings as the physiological identification of some thalamic nuclei and pallidum required during stereotactic operations for the treatment of parkinsonism (Lenz et al., 1990; Tasker et al., 1987; Raeva, 1986, 1972; Ohye, 1982; Jasper and Bertrand, 1966; Albe-Fessard et al., 1962) provide a unique opportunity to investigate how information for a verbally cueing voluntary movement is processed in human single neurons (Raeva, 1986, 1978, 1977, 1972). The aim of the present study was to analyze the characteristics of evoked activity (EA) patterns of pallidal units during the performance of a goal-directed movement in response to verbal commands and to reveal the role of the Globus Pallidus (GP) in processing of the motor information in awake human brain.
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