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Dynamic Studies on the Possible Neural Pathway Mediating Parkinsonian Symptoms (Tremor, Rigidity and Did) Using Pet Scan and Microrecording

  • Masafumi Hirato
  • Hideki Murata
  • Katsushige Watanabe
  • Akio Takahashi
  • Satoru Horikoshi
  • Takashi Shibasaki
  • Chihiro Ohye
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)

Abstract

In recent years, the development of primate models of Parkinson’s disease has made it possible to clarify some of the pathophysiological mechanisms underlying parkinsonian symptoms (akinesia, rigidity, tremor and dopa-induced dyskinesia=DID)(Crossman, 1987). A sophisticated functional architecture of basal ganglia circuits has been proposed(Alexander and Crutcher, 11990), and parkinsonian symptoms can be accounted for by postulating specific disturbances within the basal ganglia-thalamocortical motor circuit(DeLong,1990). Lesion experiments in monkeys have revealed that parkinsonian-like tremor was the result of damage to the nigrostriatal dopaminergic pathways in combination with damage to the rubro-olivo-cere-bello-rubral and cerebello-thalamic pathways(Larochelle et al., 1970). Based on experimental studies in monkeys and depth microelectrode studies in the human thalamus, a closed tremor-mediating neuronal circuit has been proposed(Ohye, 1988a; Ohye et al., 1993). However, the data in living humans remain inconsistent. We have recorded spontaneous neuronal activity in the thalamus or pallidum with the aid of microelectrodes during the course of stereotactic thalamotomy or pallidotomy, clarifying several characteristic features in Parkinson’s disease(Ohye et al., 1979, 1989). On the other hand, positron emission tomography(PET) allows measurements of regional cerebral glucose metabolism(rCMRGlu)(Sokoloff et al., 1977; Phelps et al., 1979) and cerebral blood flow(rCBF) (Frackowiak et al., 1980), which is related to the local functional activity of the central nervous system(Sokoloff, 1981). Combining both independent techniques, we have studied the neural mechanisms or on-going changes underlying movement disorders of Parkinson’s disease(Ohye et al., 1991; Hirato et al., 1991, 1993). The present study was conducted to elucidate the possible neural pathway mediating parkinsonian symptoms in human beings.

Keywords

Positron Emission Tomography Study Parkinsonian Symptom Lenticular Nucleus Basal Ganglion Circuit Human Thalamus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Alexander, G.E. and Crutcher, M.D., 1990, Functional architecture of basal ganglia circuits: neural substrates of parallel processing, Trends. Neurosci. 13:266–271.PubMedCrossRefGoogle Scholar
  2. Crossman, A.R., 1987, Primate models of dyskinesia: The experimental approach to the study of basal ganglia-related involuntary movement disorders, Neuroscience 21:1–40.PubMedCrossRefGoogle Scholar
  3. DeLong, M.R., 1990, Primate models of movement disorders of basal ganglia origin, Trend. Neurosci. 13:281–285.PubMedCrossRefGoogle Scholar
  4. Filion, M., Tremblay, L., and Bedard, P.J., 1988, Abnormal influences of passive limb movement on the activity of globus pallidus neurons in parkinsonian monkeys. Brain Res. 444:165–176.CrossRefGoogle Scholar
  5. Frackowiak, R.S.J., Lenzi, G.L., Jones, T. and Heather, J.D., 1980, Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 150 and positron emission tomography: Theory, procedure, and normal values, J. Comput. Assist. Tomogr. 4:727–736.PubMedCrossRefGoogle Scholar
  6. Hirato, M., Satake, K., Horikoshi, S., Kawashima, Y., Shibasaki, T. and Ohye, C., 1991, Characteristics of regional cerebral metabolism in cases with tremor-PET study-(Japanese), Fund. Neurosurg. 30:93–102.Google Scholar
  7. Hirato, M., Horikoshi, S., Kawashima, Y., Satake, K., Shibazaki, T. and Ohye, C., 1993, Different cerebral metabolism between parkinsonian rigidity and hyperkinesia (DID, Chorea, Dystonia)-A PET study, Adv.Neurol. 60:511–514.PubMedGoogle Scholar
  8. Hoover J.E. and Strick PL., 1993, Multiple output channels in the basal ganglia, Science 259:819–821.PubMedCrossRefGoogle Scholar
  9. Lamarre, Y., and Joffroy, A.J., 1979, Experimental tremor in monkey: activity of thalamic and precentrai cortical neurons in the absence of peripheral feedback. Adv. Neurol. 24:109–122.Google Scholar
  10. Larochelle, L., Bedard, P., Boucher, R., and Poirier, L.J., 1970, The rubro-olivo-cerebello-rubral loop and postural tremor in the monkey. J. Neurol. Sci. 11:53–64.CrossRefGoogle Scholar
  11. Mitchell, I.J., Clarke, C.E., Boyce, S., Robertson, R.G., Peggs, D., Sambrook, M.A. and Crossman, A.R., 1989, Neural mechanisms underlying Parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Neuroscience 32:213–226.PubMedCrossRefGoogle Scholar
  12. Ohye, C., 1988a, Studies on experimental tremor (Japanese), in: Handbook of Physiology (Sasaki, K., Hongo, T. eds.), vol 10, Igaku-shoin, Tokyo, pp. 243–258.Google Scholar
  13. Ohye, C., 1988b, Selective thalamotomy for movement disorders: microrecording stimulation techniques and results, in Modern Stereotactic Neurosurgery (Lunsford, L.D. ed.), Martinus Nijhoff, Boston, pp. 315–331.CrossRefGoogle Scholar
  14. Ohye, C., and Narabayashi, H., 1979, Physiological study of presumed ventralis intermedius neurons in the human thalamus. J. Neurosurg. 50:290–297.Google Scholar
  15. Ohye, C., Shibazaki, T., Hirai, T., Wada, H., Hirato, M., and Kawashima, Y., 1989, Further physiological observations on the ventralis intermedius neurons in the human thalamus. J. Neurophysiol. 61:488–500.Google Scholar
  16. Ohye, C., Shibazaki, T., Hirato, M., Kawashima, Y., Matsumura, M. and Shibazaki, T., 1991, Neural activity of the basal ganglia in Parkinson’s disease studied by depth recording and PET scan, in: Basal Ganglia 3, (G. Bernardi, M.B. Carpenter, G. Di Chiara, M. Morelli, P. Stanzione, eds.), Plenum Press, New York, pp. 637–644.CrossRefGoogle Scholar
  17. Ohye, C., Shibazaki, T., Hirai, T., Kawashima Y., Hirato, M., and Matsumura, M., 1993, Tremor-mediating thalamic zone studied in humans and in monkeys, Stereotact. Funct. Neurosurg. 60:136–145.PubMedCrossRefGoogle Scholar
  18. Phelps, M.E., Huang, S.C., Hoffman, E.J., Selin, C., Sokoloff, L. and Kuhl, D.E, 1979, Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)-2-fluoro-2-deoxy-D-glucose: Validation of method, Ann. Neurol. 6:371–388.PubMedCrossRefGoogle Scholar
  19. Roland, P.E., Larsen, B., Lassen, N.A., and Shinhoj, E., 1980, Supplementary motor area and other cortical areas in organization of voluntary movements in man. J. Neurophysiol. 43:118–136.Google Scholar
  20. Schwartz, W.J., Smith, C.B., Davidsen, L., Savaki, H., Sokoloff, L., Mata, M., Fink, D.J., and Gainer, H., Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat. Science 205:723–725.Google Scholar
  21. Sokoloff, L., 1981, Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system. Fed. Proc. 40:2311–2316.Google Scholar
  22. Sokoloff, L., Reivich, M., Kennedy, C., Des Rosiers, M.H., Patlak, C.S., Pettigrew, K.D., Sakurada, O., and Shinohara, M., 1977, The (14C)-deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat, J. Neurochem. 28:897–916.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Masafumi Hirato
    • 1
  • Hideki Murata
    • 1
  • Katsushige Watanabe
    • 1
  • Akio Takahashi
    • 1
  • Satoru Horikoshi
    • 1
  • Takashi Shibasaki
    • 1
  • Chihiro Ohye
    • 1
  1. 1.Department of NeurosurgeryGunma University School of MedicineMaebashi, GunmaJapan

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