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The Effects of Unilateral Nigrostriatal Dopamine Depletion on Learned Hand-Eye Coordination in Monkeys

  • Naoyuki Matsumoto
  • Toru Hanakawa
  • Shinichiro Maki
  • Minoru Kimura
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)

Abstract

Dysfunction of the basal ganglia and the brain nuclei interconnected with them leads to disturbances of movement and cognition. The anatomical circuit arrangement within which the basal ganglia reside is unique. Their largest input station, the striatum, collects inputs from the entire neocortex and sends processed information through other parts of the areas of frontal cortex that have been implicated in motor planning and execution. These striatal circuits are modulated by the dopamine-containing nigrostriatal tract, which degenerates in Parkinson’s disease. The striatum also receives inputs from non-specific nuclei in the thalamus and from the amygdala. This arrangement and the multiple internal loops of the basal ganglia, have led to speculation that the basal ganglia are not simply related to motor execution per se. Instead, they may participate in motor planning including predictive control and motor sequencing, motor learning, and action repertories involving motivational and cognitive drive (Graybiel et al., 1994; Kimura, 1995).

Keywords

Basal Ganglion Dopamine Neuron Dopamine Depletion Nigrostriatal Dopamine Saccade Onset 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aosaki T, Tsubokawa H, Ishida A, Watanabe K, Graybiel AM, Kimura M. 1994, Responses of tonically active neurons in the primate’s striatimi undergo systematic changes during behavioral sensory-motor conditioning. J. Neurosci. 14:3969–3984.PubMedGoogle Scholar
  2. Aosaki T, Graybiel A, Kimura M. 1994, Effect of the nigrostriatal dopamine system on acquired neural responses in the striatum of behaving monkeys. Science 265:412–415.PubMedCrossRefGoogle Scholar
  3. Apicella P, Legallet E, Nieoullon A, Trouche E. 1991, Neglect of contralateral visual stimuli in monkeys with unilateral striatal dopamine depletion. Behav. Brain Res. 46:187–195.PubMedCrossRefGoogle Scholar
  4. Ferraro FR, Balota DA, Connor LT. 1993, Implicit memory and the formation of new associations in nondemented Parkinson’s disease individuals and individuals with senile dementia of the Alzheimer type: a serial reaction time (SRT) investigation. Brain Cogn. 21:163–180.PubMedCrossRefGoogle Scholar
  5. Graybiel AM, Aosaki T, Flaherty A, Kimura M. 1994, The basal ganglia and adaptive motor control. Science 265:1826–1831.PubMedCrossRefGoogle Scholar
  6. Hikosaka O, Wurtz RH. 1983, Visual and oculomotor functions of monkey substantia nigra pars reticulata. III. Memory-contingent visual and saccade responses. J. Neurophysiol. 49:1268–1284.PubMedGoogle Scholar
  7. Hikosaka O, Sakamoto M, Usui S. 1989, Functional properties of monkey caudate neurons I. Activities related to saccadic eye movements. J. Neurophysiol. 61:780–798.PubMedGoogle Scholar
  8. Imai H, Nakamura T, Endo K, Narabayashi H. 1988, Hemiparkinsonism in monkeys after unilateral caudate nucleus infusion of l-methyl-4-phenyl-l, 2, 3, 6-tetrahydropiridine (MPTP): behavior and histology. Brain Res. 474:327–332.PubMedCrossRefGoogle Scholar
  9. Kimura M. 1990, Behaviorally contingent property of movement-related activity of the primate putamen. J. Neurophysiol. 63:1277–1296.PubMedGoogle Scholar
  10. Kimura M. 1995, Role of basal ganglia in behavioral learning. Neurosci. Res. 22:353–358.PubMedCrossRefGoogle Scholar
  11. Kimura, M, Aosaki, T, Hu, Y. Ishida A, Watanabe K. 1992, Activity of primate putamen neurons is selective to a mode of voluntary movement: sensory-triggered, self-initiated or memory-guided mode. Exp. Brain Res. 89:473–477.PubMedCrossRefGoogle Scholar
  12. Lidsky TI, Manetto C. 1987, Context-dependent activity in the striatum of bahaving cats. In: Schneider JS., Lidsky TI (Eds.) Basal ganglia and behavior: sensory aspects of motor functions: Hans Huber, Toronto, 123–133.Google Scholar
  13. Ljungberg T, Apicella P, Schultz W. 1992, Responses of dopamine neurons during learning of behavioral reactions. J. Neurophysiol. 67:145–163.PubMedGoogle Scholar
  14. Mink JW, Thach WT. 1991 Basal ganglia motor control I. nexclusive relation of pallidal discharge to five movement modes. J. Neurophysiol. 65: 273–300PubMedGoogle Scholar
  15. Mirenowicz J, Schultz W. 1994, Importance of unpredictability for reward responses in primate dopamine neurons. J. Neurophysiol. 72:1024–1027.PubMedGoogle Scholar
  16. Miyashita N, Hikosaka O, Kato M. 1995, Visual hemineglect induced by unilateral dopamine deficiency in monkeys. Neuroreport 16:1257–1260.CrossRefGoogle Scholar
  17. Pascual-Leone A, Grafman J, Clark K, Stewart M, Massaquoi S, Lou JS, Hallett M. 1993, Procedural learning in Parkinson’s disease and cerebellar degeneration. Ann Neurol 34:594–602.PubMedCrossRefGoogle Scholar
  18. Saint-CYR JA, Taylor AE, Lang AE. 1988, Procedural learning and neostriatal function in man. Brain 111:941–959.PubMedCrossRefGoogle Scholar
  19. Schultz W, Apicella P, Ljungberg T. 1993, Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning and delayed response task. J. Neurosci. 13:900–913.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Naoyuki Matsumoto
    • 1
  • Toru Hanakawa
    • 1
  • Shinichiro Maki
    • 1
  • Minoru Kimura
    • 1
  1. 1.Division of Higher Brain Function, Faculty of Health and Sport SciencesOsaka UniversityToyonaka, Osaka 560Japan

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