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Cannabinoid Receptor-Mediated Modulation of Gabaergic Transmission in the Basal Ganglia

Implications for the Treatment of Parkinson’s Disease?
  • Y. P. Maneuf
  • J. M. Brotchie
Part of the Advances in Behavioral Biology book series (ABBI, volume 47)

Abstract

Cannabinoids have been known to humanity for thousands of years and have benn used for religious, pharmaceutical and recreational purposes. However, it is only since 1964, when Goani and Mechoulam isolated the most psychoactive compound of cannabis sativa, Δ9-tetrahydrocannabinol, that the scientific interest for these compounds started to develop. In the early nineties, the cloning and pharmacological characterization of the brain cannabinoid receptor (CB1) by Matsuda et al. (1990) allowed researchers to begin to comprehensively investigate the physiological importance of cannabinoid receptor-mediated actions.

Keywords

Basal Ganglion Globus Pallidus Gaba Release GABAergic Transmission Gaba Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Y. P. Maneuf
    • 1
  • J. M. Brotchie
    • 1
  1. 1.Division of Neuroscience, School of Biological SciencesUniversity of ManchesterManchesterUK

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