Modulation of Glutamate Transmission in the Rodent and Primate Basal Ganglia by the Selective Kappa-Opioid Receptor Agonist, Enadoline
Glutamate is utilised as a transmitter in many pathways playing a key role in basal ganglia function i. e. the corticostriatal connections (Herrling, 1985) and the subthalamic nucleus efferents (Brotchie and Crossman, 1991a) to both pallidal segments and the substantia nigra pars reticulata.
KeywordsGlutamate Release Excitatory Amino Acid Globus Pallidus Internal Globus Pallidus Glutamate Transmission
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- Brotchie, J.M. and Crossman, A.R., 1991a, D-[3H]aspartate and [14C] GABA uptake in the basal ganglia of rats following lesions in the subthalamic region suggest a role for excitatory amino acid-but not GABA-mediated transmission in the subthalamic nucleus efferents, Exp. Neurol. 113: 171–181.PubMedCrossRefGoogle Scholar
- Carroll, C.B., Holloway, V., Brotchie, J.M. and Mitchell, I.J., 1995, Neurochemical and behavioral investigations of the NMDA receptor-associated glycine site in the rat striatum: functional implications for treatment of parkinsonian symptoms, Psychopharmacology 119(1): 55–65.PubMedCrossRefGoogle Scholar
- Haber, S.N., and Watson, S.J., 1983, The comparison between enkephalin-like and dynorphin-like immunore-activity in both monkey and human globus pallidus, Life Sci. Suppl. 33: 162–165.Google Scholar
- Hughes, N.R., McKnight, A., Woodruff, G.N., Crossman, A.R. and Brotchie, J.M., Anti-parkinsonian effects of K-opioid receptor agonists in the reserpine-treated rat, Movement Disorders: in press.Google Scholar
- Lambert, P.D., Woodruff, G.N., Hughes, J. and Hunter, J.C., 1991, Inhibition of L-glutamate release: a possible mechanism of action for the neuroprotective effects of the kappa-selective agonist CI-977, Mol. Neuropharm. 1: 77–82.Google Scholar
- Maneuf, Y.P., Mitchell, I.J., Crossman, A.R., Woodruff, G.N., and Brotchie, J.M., 1995, Functional implications of kappa opioid receptor-mediated modulation of glutamate transmission in the output regions of the basal ganglia in rodent and primate models of Parkinson’s disease, Brain Res. 683: 102–108.PubMedCrossRefGoogle Scholar
- Miller, W.C., and DeLong, M.R., 1987, Altered tonic activity of neurons in the globus pallidus and subthalamic nucleus in the primate MPTP model of parkinsonism, in: The Basal Ganglia, Volume II (M.A. Carpenter and A. Jarayaman, eds.), Plenum Press, New York, pp. 395–413.Google Scholar
- Mitchell, I. J., Clark, C. E., Boyce, S., Robertson, S. G., Peggs, D., Sambrook, M. A., and Crossman, A. R., 1989, Neural mechanisms underlying Parkinsonian symptoms based upon regional uptake of 2-deoxy glucose in monkeys exposed to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine, Neuroscience 32: 213–226.PubMedCrossRefGoogle Scholar
- Mitchell, I.J., Hughes, N. Carroll, C.B., and Brotchie, J.M., 1995, Reversal of parkinsonian symptoms by intrastriatal and systemic manipulations of excitatory amino acid and dopamine transmission in the bilateral 6-OHDA lesioned marmoset, Behavioural Pharamacol. 6: 492–507.Google Scholar
- Turski, L., Klockgether, T., Turski, W. A., Schwarz, M., and Sontag, K. H., 1990, Blockade of excitatory neurotransmission in the globus pallidus induces rigidity and akinesia in the rat: implications for excitatory neurotransmission in pathogenesis of Parkinson’s disease, Brain Res. 512(1): 125–131.PubMedCrossRefGoogle Scholar