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Growth Factors in the Treatment of HIV Disease

  • David T. Scadden
  • David W. Golde

Abstract

Cytokines have been portrayed as both sinner and saint in HIV disease as they play a role in both the pathogenesis of disease progression as well as its treatment. The contribution of cytokine dysregulation to the evolution of clinical decline following HIV infection has been suspected as an explanation for escape from latency as well as the wasting syndrome in advanced disease. More recently, cytokines have been implicated pathogenically in associated conditions such as Kaposi’s sarcoma and non-Hodgkin’s lymphoma (Masood et al., 1995; Wang et al., 1995; Pluda et al., 1993). While some cytokines are believed to be involved in the disease process, others have attracted attention for possible positive therapeutic manipulation of the immune response. The use of interleukin (IL)-2, IL-12, and others with potential in this setting are reviewed elsewhere in this volume.

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Immune Thrombocytopenic Purpura Mycobacterium Avium Complex Recombinant Human Erythropoietin 
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References

  1. Bagnara, G. P., Zauli, G., Giovannini, M., Re, M. C., Furlini, G., and La Placa, M., 1990, Early loss of circulating hematopoietic progenitors in HIV-1 infected subjects, Exp. Hematol. 18:426–430.PubMedGoogle Scholar
  2. Balbiano, R., Degioanni, M., Valle, M., 1994, Prevention of severe neutropenia in AIDS patients with intermittent, low-dose G-CSF (filgrastim), Int. Conf. AIDS 10:223.Google Scholar
  3. Baldwin, G. C., Gasson, J. C., Quan, S. G., Fleischmann, J., Weisbart, R., Oette, D., Mitsuyasu, R. T., and Golde, D. W., 1988, Granulocyte-macrophage colony-stimulating factor enhances neutrophil function in acquired immunodeficiency syndrome patients, Proc. Natl. Acad. Sci. USA 85:2763–2766.CrossRefPubMedGoogle Scholar
  4. Baldwin, G. C., Fuller, N. D., Roberts, R. L., Ho, D. D., and Golde, D. W., 1989, Granulocyte-and-granulocyte-macrophage colony-stimulating factors enhance neutrophil cytotoxicity toward HIV-infected cells, Blood 74:1673–1677.PubMedGoogle Scholar
  5. Ballem, P. J., Belzberg, A., Devine, D. V., Lyster, D., Spruston, B., Chambers, H., Doubroff, P., and Mikulash, K., 1992, Kinetic studies of the mechanism of thrombocytopenia in patients with human immunodeficiency virus infection, N. Engl. J. Med. 327:1779–1784.CrossRefPubMedGoogle Scholar
  6. Bermudez, L. E. M., and Young, L. S., 1990, Recombinant granulocyte-macrophage colony-stimulating factor activates human macrophages to inhibit growth or kill Mycobacterium avium complex, J. Leuk. Biol. 48:67–73.Google Scholar
  7. Bermudez, L. E., Martinelli, J., Petrofsky, M., Kolonoski, P., and Young, L. S., 1994, Recombinant granulocyte-macrophage colony-stimulating factor enhances the effects of antibiotics against Mycobacterium avium complex infection in the beige mouse model, J. Infect. Dis. 169:575–580.CrossRefPubMedGoogle Scholar
  8. Bettaieb, A., Fromont, P., Louache, E., Oksenhendler, E., Vainchenker, W., Duedari, N., and Bierling, P., 1992, Presence of cross-reactive antibody between human immunodeficiency virus (HIV) and platelet glycoproteins in HIV-related immune thrombocytopenic purpura, Blood 80:162–169.PubMedGoogle Scholar
  9. Blanchard, D. K., Michelini-Norris, M. B., Pearson, C. A., McMillen, S., and Djeu, J. Y., 1991, Production of granulocyte-macrophage colony-stimulating factor (GM-CSF) by monocytes and large granular lymphocytes stimulated with Mycobacterium avium-M. intracellulare: Activation of bactericidal activity by GM-CSF, Infect. Immun. 59:2396–24PubMedGoogle Scholar
  10. Boente, P., Sampaio, C., Brandao, M. A., Moreira, E. D., Badaro, R., and Jones, T. C., 1993, Local peri-lesional therapy with rhGM-CSF for Kaposi’s sarcoma, Lancet 341:1154.CrossRefPubMedGoogle Scholar
  11. Bozzette, S. A., Parker, R., and Hay, J., 1994, A cost analysis of approved antiretroviral strategies in persons with advanced human immunodeficiency virus disease and zidovudine intolerance, J. Acq. Immune Defic. Syndr. 7:355–362.Google Scholar
  12. Calderone, R., and Sturtevant, J., 1994, Macrophage interactions with Candida, Immunol. Ser. 60:505–515.PubMedGoogle Scholar
  13. Castella, A., Croxson, T., and Mildvan, D., 1985, The bone marrow in AIDS: A histologic, hematologic, and microbiologic study. Am. J. Clin. Pathol. 84:425–432.PubMedGoogle Scholar
  14. Chen, G. H., Curtis, J. L., Mody, C. H., Christensen, P. J., Armstrong, L. R., and Toews, G. B., 1994, Effect of granulocyte-macrophage colony-stimulating factor on rat alveolar macrophage anticryptococcal activity in vitro, J. Immunol. 152:724–734.PubMedGoogle Scholar
  15. Collins, H. L., and Bancroft, G. J., 1992, Cytokine enhancement of complement-dependent phagocytosis by macrophages: Synergy of tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor for phagocytosis of Cryptococcus neoformans, Eur. J. Immunol. 22:1447–1454.CrossRefGoogle Scholar
  16. Davey, R. T., Davey, V. J., Metcalf, J. A., Zurlo, J. J., Kovacs, J. A., Falloon, J., Polis, M. A., Zunich, K. M., Masur, H., and Lane, H. C., 1991, A Phase I/II trial of zidovudine, interferon-α, and granulocyte-macrophage colony-stimulating factor in the treatment of human immunodeficiency virus type 1 infection, J. Infect. Dis. 164:43–52.CrossRefPubMedGoogle Scholar
  17. Davis, B. R., Marx, J. C., Johnson, C. E., Berry, J. M., Lyding, J., Zander, A., Merigan, T. C., and Schwartz J., 1991, Absent or rare HIV infection of bone marrow stem/progenitor cells in vivo, J. Virol. 65:1985–1990.PubMedGoogle Scholar
  18. Dhawan, R. K., Kharbanda, S., Nakamura, M., Ohno, T., and Kufe, D., 1990, Effects of granulocyte-macrophage colony-stimulating factor on 3’-azido-3’-deoxythymidine uptake, phosphorylation and nucleotide retention in human U-937 cells, Biochem. Pharmacol 40:2695–2700.CrossRefPubMedGoogle Scholar
  19. Djeu, J.Y., 1990, Role of tumor necrosis factor and colony-stimulating factors in phagocyte function against Candida albicans, Diagn. Microbiol. Infect. Dis. 13:383–386.CrossRefPubMedGoogle Scholar
  20. Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K., Jackson, V., Hamada, H., Pardoll, D., and Mulligan, R.C., 1993, Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity, Proc. Natl. Acad. Sci. USA 90:3539–3543.CrossRefPubMedGoogle Scholar
  21. Groopman, J. E., Mitsuyasu, R. T., DeLeo, M. J., Oette, D. H., and Golde, D. W., 1987, Effect of recombinant human granulocyte-macrophage colony-stimulating factor on myelopoiesis in the acquired immunodeficiency syndrome, N. Engl. J. Med. 317:593–598.CrossRefPubMedGoogle Scholar
  22. Hammer, S. M., Gillis, J. M., Groopman, J. E., and Rose, R. M., 1986, In vitro modification of human immunodeficiency virus infection by granulocyte-macrophage colony-stimulating factor and a interferon, Proc. Natl. Acad. Sci. USA 83:8734–8738.CrossRefPubMedGoogle Scholar
  23. Harbol, A. W., Liesveld, J. L., Simpson-Haidaris, P. J., and Abboud, C. N., 1994, Mechanisms of cytopenia in human immunodeficiency virus infection, Blood Rev. 8:241–251.CrossRefPubMedGoogle Scholar
  24. Hardy, W. D., 1991, Combined anciclovir and recombinant granulocyte-macrophage colony-stimulating factor in the treatment of cytomegalovirus retinitis in AIDS patients, J. Acq. Immune Defic. Syndr. 4:S22.Google Scholar
  25. Henry, D. H., Beall, G. N., Benson, C. A., Carey, J., Cone, L. A., Eron, L. J., Fiala, M. Fischl, M. A., Gavin, S. J., and Gottlieb, M. S., 1992a, Recombinant human erythropoietin in the treatment of anemia associated with human immunodeficiency virus (HIV) infection and zidovudine therapy. Overview of four clinical trials, Ann. Intern. Med. 117:739–748.CrossRefPubMedGoogle Scholar
  26. Henry, D. H., Jemsek, J. G., Levin, A. S., Levine, J. D., Levine, R. L., Abels, R. I., Nelson, R. A., Thompson, D., and Rudnick, S. A., 1992b, Recombinant human erythropoietin and the treatment of anemia in patients with AIDS or advanced ARC not receiving ZDV, J. Acq. Immun. Defic Syndr. 5:847–852.CrossRefGoogle Scholar
  27. Jacobson, M. A., Stanley, H. D., and Heard, S. E., 1992, Ganciclovir with recombinant methionyl human granulocyte colony-stimulating factor for treatment of cytomegalovirus disease in AIDS patients [letter], AIDS 6:515–517.CrossRefPubMedGoogle Scholar
  28. Kaczmarski, R. S., Davison, F., Blair, E., Sutherland, S., Moxham, J., McManus, T., and Mufti, G. J., 1992, Detection of HIV in hematopoietic progenitors, Br. J. Hematol. 82:764–769.CrossRefGoogle Scholar
  29. Kaplan, L. D., Kahn, J. O., Crowe, S., Northfelt, D., Neville, P., Grossberg, H., Abrams, D. I., Tracey, J., Mills, J., and Volberding, P. A., 1991, Clinical and virologie effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients receiving chemotherapy for human immunodeficiency virus-associated non-Hodgkin’s lymphoma: Results of a randomized trial, J. Clin. Oncol 9:929–940.PubMedGoogle Scholar
  30. Karpatkin, S., and Nardi, M., 1992, Autoimmune anti-HIV-lgp120 antibody with antiidiotype-like activity in sera and immune complexes of HIV-1-related immunologie thrombocytopenia, J. Clin. Invest. 89:356–364.CrossRefPubMedGoogle Scholar
  31. Kemper, C. A., Bermudez, L., Agosti, J., and Deresinski, S., 1995, Immunomodulatory therapy of mycobacterium avium (MAC) bacteremia in AIDS with rhGM-CSF, Proceedings, 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco p. 177.Google Scholar
  32. Kitano, K., Abboud, C. N., Ryan, D. H., Quan, S. G., Baldwin, G. C., and Golde, D. W., 1991, Macrophage-active colony-stimulating factors enhance human immunodeficiency virus type 1 infection in bone marrow stem cells, Blood 77:1699–1705.PubMedGoogle Scholar
  33. Koyanagi, Y., O’Brien, W. A., Zhao, J. Q., Golde, D. W., Gasson, J. C., and Chen, I. S. Y., 1988, Cytokines alter production of HIV-1 from primary mononuclear phagocytes, Science 241:1673–1675.CrossRefPubMedGoogle Scholar
  34. Krown, S. E., Paredes, J., Bundow, D., Polsky, B., Gold, J. W., and Flomenberg, N., 1992, Interferon-α, zidovudine, and granulocyte-macrophage colony-stimulating factor: A Phase I AIDS Clinical Trials Group study in patients with Kaposi’s sarcoma associated with AIDS, J. Clin, Invest. 10:1344–1351.Google Scholar
  35. Laursen, A. L., Obel, N., Rungby, J., and Andersen, P. L., 1993, Phagocytosis and stimulation of the respiratory burst in neutrophils by Pneumocystis carinii, J. Infect. Dis. 168:1466–1471.CrossRefPubMedGoogle Scholar
  36. Lechner, A. J., Lamprech, K. E., Potthoff, L. H., Tredway, T. L., and Matuschak, G. M., 1994, Recombinant GM-CSF reduces lung injury and mortality during neutropenic Candida sepsis, Am. J. Physiol. 266:L561–L568.PubMedGoogle Scholar
  37. Levine, J. D., Allan, J. D., Tessitore, J. H., Falcone, N., Galasso, F., Israel, R. J., and Groopman, J. E., 1991, Recombinant human granulocyte-macrophage colony-stimulating factor ameliorates zidovudine-induced neutropenia in patients with acquired immunodeficiency syndrome (AIDS)/AIDS-related complexes, Blood 78:3148–3154.PubMedGoogle Scholar
  38. Levitz, S. M., 1991, Activation of human peripheral blood mononuclear cells by interleukin-2 and granulocyte-macrophage colony-stimulating factor to inhibit Cryptococcus neoformans, Infect. Immun. 59:3393–3397.Google Scholar
  39. Louache, E., Henri, A., Bettaieb, A., Oksenhendler, E., Raguin, G., Tulliez, M., and Vainchenker, W., 1992, Role of human immunodeficiency virus replication in defective in vitro growth of hematopoietic progenitors, Blood 80:2991–2999.PubMedGoogle Scholar
  40. McGinniss, M., Macher, A., and Rook, A., 1986, Red cell autoantibodies in patients with acquired immune deficiency syndrome. Transfusion 26:405–409.CrossRefPubMedGoogle Scholar
  41. Masood, R., Zhang, Y., Bond, M. W., Scadden, D. T., Moudgil, T., Law, R. E., Kaplan, M. H., Jung, B., Espina, B. M., Lunardi-Iskandar, Y., Levine, A. M., and Gill, P. S., 1995, Interleukin-10 is an autocrine growth factor for acquired immunodeficiency syndrome-related B-cell lymphoma, Blood 85:3423–3430.PubMedGoogle Scholar
  42. Miles, S., 1995, The use of hematopoietic growth factors in treating HIV infection, Curr. Sci. 2:227–233.Google Scholar
  43. Miles, S. A., Lee, K., Hutlin, L., Zsebo, K. M., and Mitsuyasu, R. T., 1991a, Potential use of human stem cell factor as adjunctive therapy for human immunodeficiency virus-related cytopenias, Blood 78:3200–3208.PubMedGoogle Scholar
  44. Miles, S. A., Mitsuyasu, R. T., Moreno, J., Baldwin, G., Alton, N. K., Souza, L., and Glaspy, J. A., 1991b, Combined therapy with recombinant granulocyte colony-stimulating factor and erythropoietin decreases hematologic toxicity from zidovudine, Blood 77:2109–2117.PubMedGoogle Scholar
  45. Molina, J. M., Scadden, D. T., Molina, J. M., Groopman, J. E., Sakaguchi, M., Fuller, B., and Woon, A., 1990, Lack of evidence for infection of or effect on growth of hematopoietic progenitor cells after in vivo or in vitro exposure to human immunodeficiency virus, Blood 76:2476–2482.PubMedGoogle Scholar
  46. Moore, R. D., Keruly, J. C., and Chaisson, R. E., 1995, Neutropenia and bacterial infection in AIDS, Proceedings, 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco (abstract) p. 250.Google Scholar
  47. Murphy, M., Metcalf, P., and Waters, A., 1987, Incidence and mechanism of neutropenia and thrombocytopenia in patients with human immunodeficiency virus infection, Br. J. Haematol. 66:337–340.CrossRefPubMedGoogle Scholar
  48. Nassar, F., Brummer, E., and Stevens, D. A., 1994, Effect of in vivo macrophage colony-stimulating factor on fungistasis of bronchoalveolar and peritoneal macrophages against Cryptococcus neoformans, Anti-microb. Agents Chemother. 38:2162–2164.CrossRefGoogle Scholar
  49. Perno, C. F., Yarchoan, R., Cooney, D. A., Hartman, N. R., Webb, D. S., Hao, Z., Mitsuya, H., Johns, D. G., and Broder, S., 1989, Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3’-azido-2’3’-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine, J. Exp. Med. 169:933–951.CrossRefPubMedGoogle Scholar
  50. Perno, C. E., Cooney, D. A., Gao, W. Y., Hao, Z., Johns, D. G., Foli, A., Hartman, N. R., Calio, R., Broder, S., and Yarchoan, R., 1992, Effects of bone marrow stimulatory cytokines on human immunodeficiency virus replication and the antiviral activity of dideoxynucleosides in cultures of monocyte/macrophages, Blood 80:995–1003.PubMedGoogle Scholar
  51. Phair, J. P., Abels, R. I., McNeill, M. V., and Sullivan, D. J., 1993, Recombinant human erythropoietin treatment: Investigational new drug protocol for the anemia of the acquired immunodeficiency syndrome, Arch. Intern. Med. 153:2669.CrossRefPubMedGoogle Scholar
  52. Pluda, J. M., Yarchoan, Y.R., and Smith, P. D., 1990, Subcutaneous recombinant granulocyte-macrophage colony-stimulating factor used as a single agent and in an alternative regimen with azidothymidine in leukopenia patients with severe human immunodeficiency virus infection, Blood 76:2303.Google Scholar
  53. Pluda, J. M., Venzon, D. J., Tosato, G., Lietzau, J., Wyvill, K., Nelson, D. L., Jaffe, E. S., Karp, J. E., Broder, S., and Yarchoan, R., 1993, Parameters affecting the development of non-Hodgkin’s lymphoma in patients with severe human immunodeficiency virus infection receiving antiretroviral therapy, J. Clin. Oncol. 11:1099–1107.PubMedGoogle Scholar
  54. Ratnoff, O. D., Menitove, J. E., Aster, R. H., and Lederman, M. M., 1983, Coincident classic hemophilia and “idiopathic” thrombocytopenic purpura in patients under treatment with concentrates of anti-hemophilic factor (Factor VIII), N. Engl. J. Med. 308:439–442.CrossRefPubMedGoogle Scholar
  55. Richardson, M. D., Brownlie, C. E., and Shankland, G. S., 1992, Enhanced phagocytosis and intracellular killing of Candida albicans by GM-CSF-activated human neutrophils, J. Med. Vet. Mycol. 30:433–441.CrossRefPubMedGoogle Scholar
  56. Robin, G., Markovich, S., Athamna, A., and Keisari, Y., 1991, Human recombinant granulocyte-macrophage colony-stimulating factor augments viability and cytotoxic activities of human monocyte-derived macrophages in long-term cultures, Lymphokine Cytokine Res. 10:257–263.PubMedGoogle Scholar
  57. Scadden, D. T., and Agosti, J., 1993, No antibodies to granulocyte macrophage colony-stimulating factor with prolonged use in AIDS [letter], AIDS 7:438.CrossRefPubMedGoogle Scholar
  58. Scadden, D. T., Zon, L. I., and Groopman, J. E., 1989, Pathophysiology and management of HIV-associated hematologic disorders, Blood 74:1455.PubMedGoogle Scholar
  59. Scadden, D. T., Zeira, M., Woon, A., Wang, Z., Schieve, L., Ikeuchi, K., Lim, B., and Groopman, J. E., 1990, HIV infection of human bone marrow stromal fibroblasts, Blood 76:317–322.PubMedGoogle Scholar
  60. Scadden, D. T., Bering, H. A., Levine, J. D., Bresnahan, J., Evans, L., Epstein, C., and Groopman, J. E., 1991, Granulocyte-macrophage colony-stimulation factor mitigates the neutropenia of combined interferon alfa and zidovudine treatment of acquired immune deficiency syndrome-associated Kaposi’s sarcoma, J. Clin. Oncol. 9:802–808.PubMedGoogle Scholar
  61. Scadden, D. T., Levine, J. D., Bresnahan, J., Gere, J., McGrath, J., Wang, Z., Resta, D. J., Young, D., and Hammer, S. M., 1995, In vivo effects of interleukin-3 in HIV-1 infected patients with cytopenia, AIDS Res. Hum. Retrovir. 11:731–740.CrossRefPubMedGoogle Scholar
  62. Scadden, D. T., Wang, A., Zsebo, K. M., and Groopman, J. E., 1994, In vitro effects of stem cell factor or interleukin-3 on myelosuppression associated with AIDS, AIDS 8:193–196.CrossRefPubMedGoogle Scholar
  63. Sloand, E. M., Klein, H. G., Banks, S. M., Vareldzis, B., Merritt, S., and Pierce, P., 1992, Epidemiology of thrombocytopenia in HIV infection, Eur. J. Haematol 48:168–172.CrossRefPubMedGoogle Scholar
  64. Smith, P. D., Lamerson, C. L., Banks, S. M., Saini, S. S., Wahl, L. M., Calderone, R. A., and Wahl, S. M., 1990, Granulocyte-macrophage colony-stimulating factor augments human monocyte fungicidal activity for Candida albicans, J. Infect. Dis. 161:999–1005.CrossRefPubMedGoogle Scholar
  65. Steinberg, H. N., Crumpacker, C. S., and Chatis, P. A., 1991, In vitro suppression of normal human bone marrow progenitor cells by human immunodeficiency virus, J. Virol. 65:1765–1769.PubMedGoogle Scholar
  66. Taylor, M. B., and Easmon, C. S. F., 1991, The neutrophil chemiluminescence response to Pneumocystis carinii is stimulated by GM-CSF and gamma interferon, FEMS Microbiol. Immunol. 89:41–44.CrossRefGoogle Scholar
  67. Treacy, M., Lai, I., Costello, C., and Clark, A., 1987, Peripheral blood and bone marrow abnormalities in patients with HIV related disorders, Br. J. Haematol. 65:289–294.CrossRefPubMedGoogle Scholar
  68. von Lear, D., Hufert, F. T., Fenner, T. E., Schwander, S., Dietrich, M., Schmitz, H., and Kern, P., 1990, CD34+ hematopoietic progenitor cells are not a major reservoir of the human immunodeficiency virus, Blood 76:1281–1286.Google Scholar
  69. Wang, C-Y. E., Schroeter, A. L., and Su, W. P. D., 1995, Acquired immunodeficiency syndrome-related Kaposi’s sarcoma, Mayo Clin. Proc. 70:869–879.PubMedGoogle Scholar
  70. Wang, Z., Goldberg, M., and Scadden, D. T., 1993, HIV-1 suppresses erythropoietin production in vitro, Exp. Hematol. 21:683–688.PubMedGoogle Scholar
  71. Zauli, G., Furlini, G., Vitale, M., Re, M. C., Gibellini, D., Zamai, L., Visani, G., Borgatti, P., Capitani, S., and La Placa, M., 1994, A subset of human CD34+ hematopoietic progenitors express low levels of CD4, the high-affinity receptor for human immunodeficiency virus-type 1, Blood 84:1896–1905.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • David T. Scadden
    • 1
  • David W. Golde
    • 2
    • 3
  1. 1.Massachusetts General Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.Cornell University Medical CollegeNew YorkUSA

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