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Role of Platelet-Derived Growth Factor in Vivo

  • Carl-Henrik Heldin
  • Bengt Westermark

Abstract

Platelet-derived growth factor (PDGF) was originally identified as a mitogen for fibroblasts, smooth muscle cells, and glial cells (Kohler and Lipton, 1974; Ross et al., 1974; Westermark and Wasteson, 1976). PDGF was subsequently purified from human platelets (Antoniades et al., 1979; Deuel et al., 1981; Heldin et al., 1979; Raines and Ross, 1982). More recent studies have shown that PDGF is synthesized by a number of cell types and also acts on many different cell types (for reviews on PDGF, see Heldin and Westermark, 1990; Raines et al., 1990).

Keywords

Idiopathic Pulmonary Fibrosis Mesangial Cell Derive Growth Factor Signal Transduction Molecule Excisional Wound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Carl-Henrik Heldin
    • 1
  • Bengt Westermark
    • 2
  1. 1.Ludwig Institute for Cancer ResearchBiomedical CenterUppsalaSweden
  2. 2.Department of PathologyUniversity HospitalUppsalaSweden

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