Protective Effect of Taurine against Reperfusion Injury in Cultured Rat Astrocytes
Astrocytes, the most abundant glial cells in the brain, are considered to have physiological and pathological roles in neuronal activities. Goldman et al. 3 and we11 independently reported that the Na+/Ca2+ exchanger is present in cultured astrocytes. The Na+/Ca2+ exchanger plays an important role in regulation of [Ca2+]i, the antiporter being bi-directional: the forward mode causes Ca2+ efflux, and the reverse mode causes Ca2+ influx.
KeywordsExchange Activity Reperfusion Injury Reverse Mode Cell Toxicity Brain Ischemic Damage
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- 3.Goldman, W.F., Yarowsky, P.J., Juhaszova, M., Krueger, B.K., and Blaustein, M.P. 1994, Sodium/calcium exchange in rat cortical astrocytes, J.Neurosci. 14:5834–5843.Google Scholar
- 6.Kramer, J.H., Chovan, J.P., and Schaffer, S.W. 1981, Effect of taurine on calcium paradox and ischemic heart failure, Am.J.Physiol. 240:H238–H246.Google Scholar
- 7.Matsuda, T., Gemba, T., Baba, A., and Iwata, H. 1989, Inhibition by taurine of Na+-Ca2+ exchange in sarcolemmal membrane vesicles from bovine and guinea pig hearts, Comp.Biochem.Physiol. 94C:335–339.Google Scholar
- 9.Matsuda, T., Takuma, K., Nishiguchi, E., Asano, S., Hashimoto, H., Azuma, J. and Baba, A. 1996, Involvement of Na+-Ca2+ exchanger in reperfusion-induced delayed cell death of cultured rat astrocytes, Eur.J.Neurosci. in press.Google Scholar